| Title: |
Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia |
| Authors: |
Bergeron, D; Gorno-Tempini, ML; Rabinovici, GD; Santos-Santos, MA; Seeley, W; Miller, BL; Pijnenburg, Y; Keulen, MA; Groot, C; van Berckel, BNM; van der Flier, WM; Scheltens, P; Rohrer, JD; Warren, JD; Schott, JM; Fox, NC; Sanchez-Valle, R; Grau-Rivera, O; Gelpi, E; Seelaar, H; Papma, JM; van Swieten, JC; Hodges, JR; Leyton, CE; Piguet, O; Rogalsky, EJ; Mesulam, MM; Koric, L; Nora, K; Pariente, J; Dickerson, B; Mackenzie, IR; Hsiung, G-YR; Belliard, S; Irwin, DJ; Wolk, DA; Grossman, M; Jones, M; Harris, J; Mann, D; Snowden, JS; Chrem-Mendez, P; Calandri, IL; Amengual, AA; Miguet-Alfonsi, C; Magnin, E; Magnani, G; Santangelo, R; Deramecourt, V; Pasquier, F; Mattsson, N; Nilsson, C; Hansson, O; Keith, J; Masellis, M; Black, SE; Matías-Guiu, JA; Cabrera-Martin, M-N; Paquet, C; Dumuirger, J; Teichmann, M; Sarazin, M; Bottlaender, M; Dubois, B; Rowe, CC; Villemagne, VL; Vandenberghe, R; Granadillo, E; Teng, E; Mendez, M; Meyer, PT; Frings, L; Lleó, A; Blesa, R; Fortea, J; Seo, SW; Diehl-Schmid, J; Grimmer, T; Frederiksen, KS; Sánchez-Juan, P; Chételat, G; Jansen, W; Bouchard, RW; Robert, L; Visser, PJ; Ossenkoppele, R |
| Source: |
Annals of Neurology , 84 (5) pp. 729-740. (2018) |
| Publication Year: |
2018 |
| Collection: |
University College London: UCL Discovery |
| Description: |
OBJECTIVE: To estimate the prevalence of amyloid-positivity, defined by PET/CSF biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants. METHODS: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n=443], non-fluent [nfvPPA, n=333], semantic [svPPA, n=401] and mixed/unclassifiable [PPA-M/U, n=74] variants of PPA) from 36 centers, with a measure of amyloid-β pathology (CSF [n=600]), PET [n=366] and/or autopsy [n=378]) available. The estimated prevalence of amyloid-positivity according to PPA variant, age and apolipoprotein E (APOE) ε4 status was determined using generalized estimating equation models. RESULTS: Amyloid-β positivity was more prevalent in lvPPA (86%) than in nfvPPA (20%) or svPPA (16%) (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10060923/1/Fox_ana.25333.pdf; https://discovery.ucl.ac.uk/id/eprint/10060923/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10060923/1/Fox_ana.25333.pdf; https://discovery.ucl.ac.uk/id/eprint/10060923/ |
| Rights: |
open |
| Accession Number: |
edsbas.75734ABC |
| Database: |
BASE |