| Title: |
22 Cellular & Molecular Immunology Review MHC Class I Antigen Presentation- Recently Trimmed and Well Presented |
| Authors: |
Barry Flutter; Bin Gao |
| Contributors: |
The Pennsylvania State University CiteSeerX Archives |
| Source: |
http://www.cmi.ustc.edu.cn/1/1/22.pdf. |
| Collection: |
CiteSeerX |
| Description: |
Presentation of antigenic peptide to T cells by major histocompatibility complex (MHC) class I molecules is the key to the cellular immune response. Non-self intracellular proteins are processed into short peptides and transported into endoplasmic reticulum (ER) where they are assembled with class I molecules assisted by several chaperone proteins to form trimeric complex. MHC class I complex loaded with optimised peptides travels to the cell surface of antigen presentation cells to be recognised by T cells. The cells presenting non-self peptides are cleared by CD8 positive T cells. In order to ensure that T cells detect an infection or mutation within the target cells the process of peptide loading and class I expression must be carefully regulated. Many of the cellular components involved in antigen processing and class I presentation are known and their various functions are now becoming clearer. Cellular & Molecular Immunology. 2004;1(1):22-30. Key Words: antigen presentation, MHC class I, T cell epitope, peptide loading |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.408.4629; http://www.cmi.ustc.edu.cn/1/1/22.pdf |
| Availability: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.408.4629; http://www.cmi.ustc.edu.cn/1/1/22.pdf |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: |
edsbas.75855B2 |
| Database: |
BASE |