The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers
| Title: | The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers |
|---|---|
| Authors: | Bancroft, Elizabeth K; Page, Elizabeth C; Brook, Mark N; Pope, Jennifer; Thomas, Sarah; Myhill, Kathryn; Helfand, Brian T; Talaty, Pooja; Ong, Kai-Ren; Douglas, Emma; Cook, Jackie; Rosario, Derek J; Salinas, Monica; Buys, Saundra S; Anson, Jo; Davidson, Rosemarie; Longmuir, Mark; Side, Lucy; Eccles, Diana M; Tischkowitz, Marc; Taylor, Amy; Cruellas, Mara; Ballestero, Eduard Perez; Cleaver, Ruth; Varughese, Mohini; Barwell, Julian; LeButt, Mandy; Greenhalgh, Lynn; Hart, Rachel; Azzabi, Ashraf; Jobson, Irene; Cogley, Lynn; Evans, D Gareth; Rothwell, Jeanette; Hogben, Matthew; Saya, Sibel; Eeles, Rosalind A; Aaronson, Neil K; The Impact Study Steering Committee And Collaborators |
| Source: | Bancroft, E K, Page, E C, Brook, M N, Pope, J, Thomas, S, Myhill, K, Helfand, B T, Talaty, P, Ong, K-R, Douglas, E, Cook, J, Rosario, D J, Salinas, M, Buys, S S, Anson, J, Davidson, R, Longmuir, M, Side, L, Eccles, D M, Tischkowitz, M, Taylor, A, Cruellas, M, Ballestero, E P, Cleaver, R, Varughese, M, Barwell, J, LeButt, M, Greenhalgh, L, Hart, R, Azzabi, A, Jobson, I, Cogley, L, Evans, D G, Rothwell, J, Hogben, M, Saya, S, Eeles, R A, Aaronson, N K & The Impact Study Steering Committee And Collaborators 2024, 'The psychosocial impact .... |
| Publication Year: | 2024 |
| Collection: | The University of Manchester: Research Explorer - Publications |
| Subject Terms: | Humans; Male; Prostatic Neoplasms/psychology; Middle Aged; Aged; Genetic Predisposition to Disease/psychology; Early Detection of Cancer/psychology; Quality of Life; Genes; BRCA1; Surveys and Questionnaires; BRCA2; Heterozygote; Anxiety/etiology; Longitudinal Studies |
| Description: | Objectives: To report the long-term outcomes from a longitudinal psychosocial study that forms part of the ‘Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls’ (IMPACT) study. The IMPACT study is a multi-national study of targeted prostate cancer (PrCa) screening in individuals with a known germline pathogenic variant (GPV) in either the BReast CAncer gene 1 (BRCA1) or the BReast CAncer gene 2 (BRCA2). Subjects and Methods: Participants enrolled in the IMPACT study were invited to complete a psychosocial questionnaire prior to each annual screening visit for a minimum of 5 years. The questionnaire included questions on sociodemographics and the following measures: Hospital Anxiety and Depression Scale, Impact of Event Scale, 36-item Short-Form Health Survey, Memorial Anxiety Scale for PrCa, Cancer Worry Scale, risk perception and knowledge. Results: A total of 760 participants completed questionnaires: 207 participants with GPV in BRCA1, 265 with GPV in BRCA2 and 288 controls (non-carriers from families with a known GPV). We found no evidence of clinically concerning levels of general or cancer-specific distress or poor health-related quality of life in the cohort as a whole. Individuals in the control group had significantly less worry about PrCa compared with the carriers; however, all mean scores were low and within reported general population norms, where available. BRCA2 carriers with previously high prostate-specific antigen (PSA) levels experience a small but significant increase in PrCa anxiety (P = 0.01) and PSA-specific anxiety (P < 0.001). Cancer risk perceptions reflected information provided during genetic counselling and participants had good levels of knowledge, although this declined over time. Conclusion: This is the first study to report the longitudinal psychosocial impact of a targeted PrCa screening programme for BRCA1 and BRCA2 carriers. The results reassure that an annual PSA-based screening programme ... |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 1464-4096; 1464-410X |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38839570; info:eu-repo/semantics/altIdentifier/pissn/1464-4096; info:eu-repo/semantics/altIdentifier/eissn/1464-410X |
| DOI: | 10.1111/bju.16432 |
| Availability: | https://research.manchester.ac.uk/en/publications/e44b5405-0661-4499-b4a9-ac7d83e16c00; https://doi.org/10.1111/bju.16432; https://www.scopus.com/pages/publications/85199880453 |
| Rights: | info:eu-repo/semantics/closedAccess |
| Accession Number: | edsbas.75CA49FF |
| Database: | BASE |