| Title: |
Vitamin D deficiency is common in kidney transplant recipients, but is not associated with infections after transplantation |
| Authors: |
Schreiber, Peter W.; Kusejko, Katharina; Bischoff-Ferrari, Heike A.; Boggian, Katia; Bonani, Marco; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H.; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J.; Swiss Transplant Cohort Study (STCS) |
| Contributors: |
De Geest, Sabina |
| Source: |
ISSN:0902-0063 ; ISSN:1399-0012 ; Clinical Transplantation, vol. 34 (2), Art.No. ARTN e13778, (e13778-e13778. |
| Publisher Information: |
Wiley |
| Publication Year: |
2020 |
| Subject Terms: |
infections; infectious disease medicine; kidney transplantation; vitamin D; Cohort Studies; Humans; Transplant Recipients; Vitamin D Deficiency; Science & Technology; Life Sciences & Biomedicine; Surgery; Transplantation; 25-HYDROXYVITAMIN D LEVEL; METABOLISM; ENDOCRINE; RISK; Swiss Transplant Cohort Study (STCS); 1103 Clinical Sciences; 3202 Clinical sciences |
| Description: |
The relevance of vitamin D for infections after kidney transplantation is poorly defined. 25-OH vitamin D (25-OHD) levels of 135 kidney transplant recipients, enrolled in the Swiss Transplant Cohort Study, were determined peri-transplant and 6 months post-transplant. Logistic regression was used to address the associations of 25-OHD and overall infections and bacterial infections, respectively. For the first 6 months post-transplant, 25-OHD peri-transplant, and for the second period (after 6 to 30 months post-transplant), 25-OHD at 6 months post-transplant was considered. Vitamin D deficiency was common peri-transplant and remained highly prevalent 6 months after transplantation despite frequent supplementation. Median 25-OHD levels increased from 12.0 ng/mL (IQR 5.3-19.5) peri-transplant to 16.5 ng/mL (IQR 10.6-22.6) 6 months post-transplant (P = .005). We did not detect a significant association between 25-OHD and overall infections (adjusted odds ratio (aOR) 1.05, 95% confidence interval (95%CI) 0.44-2.51; aOR 0.67, 95%CI 0.31-1.43) or bacterial infections (aOR 0.79, 95%CI 0.32-1.96; aOR 0.79, 95%CI 0.35-1.75) for the first and second period. To conclude, at both time points, vitamin D deficiency was observed in more than 50% of kidney recipients, albeit an increase in 25-OHD in the longitudinal course was observed. No significant association between 25-OHD and infections was detected. ; sponsorship: Swiss University Hospitals and transplant centers; Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung (Swiss University Hospitals and transplant centers, Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung) ; status: Published |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://lirias.kuleuven.be/handle/123456789/650226; https://doi.org/10.1111/ctr.13778; https://pubmed.ncbi.nlm.nih.gov/31904893 |
| DOI: |
10.1111/ctr.13778 |
| Availability: |
https://lirias.kuleuven.be/handle/123456789/650226; https://lirias.kuleuven.be/retrieve/63ac33a7-66ed-4ce0-a282-5f7adad75a63; https://doi.org/10.1111/ctr.13778; https://pubmed.ncbi.nlm.nih.gov/31904893 |
| Rights: |
info:eu-repo/semantics/openAccess ; public |
| Accession Number: |
edsbas.75DA38C5 |
| Database: |
BASE |