| Title: |
Association between endo-histological outcomes and colonic mucosal transcriptomic profiles in patients with ulcerative colitis receiving filgotinib |
| Authors: |
Magro, Fernando; Rogler, Gerhard; Feagan, Brian G; Peyrin-Biroulet, Laurent; Oortwijn, Alessandra; Cougnaud, Laure; Faes, Margaux; Bauer, Yasmina; Randall, Matthew; Rudolph, Christine; Reinisch, Walter |
| Contributors: |
Gilead Sciences, Inc |
| Source: |
Journal of Crohn's and Colitis ; volume 20, issue 2 ; ISSN 1873-9946 1876-4479 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background Filgotinib, a Janus kinase 1-preferential inhibitor, is approved for the treatment of moderately to severely active ulcerative colitis (UC). Aim To assess the effects of filgotinib on endo-histological outcomes and tissue RNA sequencing data from the SELECTION trial (NCT02914522). Methods This analysis assessed single and composite endo-histological improvement and remission endpoints at week (W) 10 and W58 in patients with moderately to severely active UC receiving once-daily filgotinib 200 mg (FIL200) or 100 mg, or placebo. Post hoc RNA sequencing analysis was performed on colonic mucosal biopsies from baseline and W10. Comparisons were made between patients who did and did not achieve endo-histological outcomes at W10 and treatment arms. Results Greater proportions of patients achieved single and composite endo-histological improvement and remission endpoints with FIL200 than placebo at W10 and W58 (endo-histological remission, W10: 6.7% vs 1.8%; P = 0.0021; W58: 12.1% vs 5.1%; P = 0.0485). Differentially expressed genes between baseline and W10 that were associated with histologic remission at W10 had upregulated and downregulated expression opposite to that of an active UC signature. Patients treated with FIL200, achieving endoscopic improvements or histological remission, exhibited reduced neutrophil-related gene expression (eg, neutrophil migration, P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ecco-jcc/jjaf228 |
| DOI: |
10.1093/ecco-jcc/jjaf228/66540262/jjaf228.pdf |
| Availability: |
https://doi.org/10.1093/ecco-jcc/jjaf228; https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjaf228/66540262/jjaf228.pdf; https://academic.oup.com/ecco-jcc/article-pdf/20/2/jjaf228/66540262/jjaf228.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.75E09442 |
| Database: |
BASE |