| Title: |
Prevalence and factors associated with dementia in Lesotho: A cross‐sectional, population‐based study |
| Authors: |
Johnson, Natalie E.; Belus, Jennifer M.; Gerber, Felix; Lee, Tristan T.; Ayakaka, Irene; Letsoela, Pearl; Molulela, Manthabiseng; Chammartin, Frédérique; Amstutz, Alain; Labhardt, Niklaus D. |
| Source: |
Johnson, N E, Belus, J M, Gerber, F, Lee, T T, Ayakaka, I, Letsoela, P, Molulela, M, Chammartin, F, Amstutz, A & Labhardt, N D 2025, 'Prevalence and factors associated with dementia in Lesotho: A cross‐sectional, population‐based study', Alzheimer's and Dementia, vol. 21, no. 2, e14614. https://doi.org/10.1002/alz.14614 |
| Publication Year: |
2025 |
| Collection: |
University of Bristol: Bristol Reserach |
| Subject Terms: |
dementia; Lesotho; lifestyle; body mass index; physical activity |
| Description: |
INTRODUCTION Limited research has examined dementia prevalence and associated factors in Lesotho. This study investigates dementia prevalence and the associated factors in Lesotho. METHODS A survey in Lesotho included 1738 participants screened for dementia and potential associated factors with a focus on modifiable factors. Associations were evaluated using logistic regression models. RESULTS The median age was 66 years, with 54.83% women. The prevalence of dementia was 4.89%. Those with depressive symptoms (adjusted odds ratio [aOR]: 3.97, 95% confidence interval [CI]: 1.39–11.30), age ≥ 75 (aOR: 2.68, 95% CI: 1.42–5.04), and underweight (aOR 2.30, 95% CI: 1.23–4.29) had increased odds of dementia. Those with moderate (aOR: 0.32, 95% CI: 0.17–0.58) to high (aOR: 0.35, 95% CI: 0.16–0.77) physical activity and obesity (aOR: 0.30, 95% CI: 0.11–0.80) presented lower odds for dementia. DISCUSSION This study provides a contemporary estimate of dementia prevalence in Lesotho, highlighting an association with modifiable factors. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40000020; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1983/f0bb73be-780d-4c0b-8412-c4395ddf031e |
| DOI: |
10.1002/alz.14614 |
| Availability: |
https://hdl.handle.net/1983/f0bb73be-780d-4c0b-8412-c4395ddf031e; https://research-information.bris.ac.uk/en/publications/f0bb73be-780d-4c0b-8412-c4395ddf031e; https://doi.org/10.1002/alz.14614 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.760B218F |
| Database: |
BASE |