| Title: |
Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease |
| Authors: |
Russell, Ashley L.; Tasker, Jeffrey G.; Lucion, Aldo B.; Fiedler, Jenny; Munhoz, Carolina D.; Wu, Tao yiao John; Deak, Terrence |
| Source: |
Journal of Neuroendocrinology |
| Publisher Information: |
Blackwell Publishing Ltd |
| Publication Year: |
2018 |
| Collection: |
Universidad de Chile: Repositorio académico |
| Subject Terms: |
anxiety; depression; glucocorticoids; inflammation; oxytocin; stress; traumatic brain injury |
| Description: |
© 2018 British Society for Neuroendocrinology Effective coordination of the biological stress response is integral for the behavioural well-being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine system and the sympathetic nervous system. The hypothalamic-pituitary-adrenal (HPA) axis plays a key role in orchestrating the bodily responses to stress, and the activity of the axis can be modified by a wide range of experiential events. This review focuses on several factors that influence subsequent HPA axis reactivity. Some of these factors include early-life adversity, exposure to chronic stress, immune activation and traumatic brain injury. The central premise is that each of these experiences serves as a general vulnerability factor that accelerates future HPA axis reactivity in ways that make individuals more sensitive to stress challenges, therefore feeding forward into the exacerbation of ongoing (or greater susceptibility toward) future stress-r |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream |
| Language: |
English |
| ISSN: |
13652826; 09538194 |
| Relation: |
Journal of Neuroendocrinology, Volumen 30, Issue 10, 2018; https://repositorio.uchile.cl/handle/2250/167668 |
| DOI: |
10.1111/jne.12641 |
| Availability: |
https://doi.org/10.1111/jne.12641; https://repositorio.uchile.cl/handle/2250/167668 |
| Rights: |
Attribution-NonCommercial-NoDerivs 3.0 Chile ; http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ |
| Accession Number: |
edsbas.76126FFF |
| Database: |
BASE |