| Title: |
Conditional Metastasis of Uveal Melanoma in 8091 Patients over Half-Century (51 Years) by Age Group: Assessing the Entire Population and the Extremes of Age |
| Authors: |
Shields, Carol L.; Samuelson, Annika; Oh, Glenn; DeSimone, Joseph D.; Sajjadi, Zaynab; Bas, Zeynep; Kalafatis, Nicholas E; Lally, Sara E.; Shields, Jerry A.; Dockery, Philip W. |
| Source: |
Wills Eye Hospital Papers |
| Publisher Information: |
Jefferson Digital Commons |
| Publication Year: |
2023 |
| Collection: |
Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) |
| Subject Terms: |
humans; infant; newborn; child; preschool; adolescent; young adult; adult; retrospective studies; uveal neoplasms; melanoma; survival analysis; survival rate; Neoplasms; Ophthalmology |
| Description: |
PURPOSE: To evaluate cumulative incidence of metastasis at specific timepoints after treatment of uveal melanoma in a large cohort of patients and to provide comparison of conditional outcomes in the youngest and oldest cohorts (extremes of age). METHODS: Retrospective analysis of 8091 consecutive patients with uveal melanoma at a single center over a 51-year period. The patients were categorized by age at presentation (0-29 years [n = 348, 4%], 30-59 years [n = 3859, 48%], 60-79 years [n = 3425, 42%], 80 to 99 years [n = 459, 6%]) and evaluated for nonconditional (from presentation date) and conditional (from specific timepoints after presentation) cumulative incidence of metastasis at five, 10, 20, and 30 years. RESULTS: For the entire population of 8091 patients, five-year/10-year/20-year/30-year nonconditional cumulative incidence of metastasis was 15%/23%/32%/36%, and the conditional incidence improved to 6%/15%/25%/30% for patients who did not develop metastasis in the first three years. For the extremes of age (0-29 years and 80-99 years), the nonconditional cumulative incidence of metastasis revealed the younger cohort with superior outcomes at 8%/15%/19%/27% and 21%/29%/29%/29%, respectively (P < 0.001). The conditional incidence (at one-year and two-year timepoints with metastasis-free survival) showed persistent superior younger cohort survival (P < 0.001, P = 0.001), but no further benefit for patients with three-year metastasis-free survival at 4%/12%/16%/24% and 7%/18%/18%/18%, respectively (P = 0.09). CONCLUSIONS: Non-conditional metastasis-free survival analysis for patients with uveal melanoma revealed the youngest cohort to have significantly better survival than the oldest cohort, and this persisted into one-year and two-year conditional metastasis-free survival but diminished at the three-year conditional timepoint. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://jdc.jefferson.edu/willsfp/195; https://jdc.jefferson.edu/context/willsfp/article/1195/viewcontent/Conditional_Metastasis_of_Uveal_Melanoma.pdf |
| Availability: |
https://jdc.jefferson.edu/willsfp/195; https://jdc.jefferson.edu/context/willsfp/article/1195/viewcontent/Conditional_Metastasis_of_Uveal_Melanoma.pdf |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.7612DA2C |
| Database: |
BASE |