| Title: |
One-year clinical outcomes in patients with acute coronary syndrome treated with clopidogrel versus prasugrel versus ticagrelor: Results of the Polish Registry of Acute Coronary Syndromes (PL-ACS) |
| Authors: |
Umińska, Julia M; Skrzypek, Michał; Ostrowska, Małgorzata; Adamski, Piotr; Kubica, Aldona; Niezgoda, Piotr; Gajda, Robert; Gierlotka, Marek; Hudzik, Bartosz; Kuliczkowski, WIktor; Gorog, Diana A; Gurbel, Paul A; Siller-Matula, Jolanta; Szarpak, Łukasz; Savage, Michael; Skonieczny, Grzegorz; Tantry, Udaya; Trzeciak, Przemysław; Navarese, Eliano P; Kubica, Jacek; Gąsior, Mariusz |
| Source: |
Polish Heart Journal (Kardiologia Polska); Vol 83, No 10 (2025); 1142-1151 |
| Publisher Information: |
Polish Cardiac Society |
| Publication Year: |
2025 |
| Collection: |
Via Medica Journals |
| Subject Terms: |
acute coronary syndrome; clopidogrel; PL-ACS Registry; prasugrel; ticagrelor |
| Description: |
Background: Efficient dual antiplatelet therapy is crucial in reducing adverse cardiovascular events in patients with acute coronary syndrome (ACS). Comparative effectiveness between clopidogrel, prasugrel, and ticagrelor remains unclear in real-world settings.Aims: The objective was to evaluate one-year clinical outcomes in ACS patients treated with clopidogrel, prasugrel, or ticagrelor using data from the Polish Registry of Acute Coronary Syndromes (PL-ACS).Material and methods: This retrospective cohort study analyzed 381 278 ACS patients from the PL-ACS registry from 2009 to 2022, who were treated with clopidogrel, prasugrel, or ticagrelor during hospitalization with a 12-month consistent regimen. The primary outcome was one-year all-cause mortality. Secondary outcomes included a composite of death, myocardial infarction, or stroke, and the net clinical outcome, a composite of all-cause death, myocardial infarction, stroke, and bleeding. Propensity score matching was applied to reduce confounding factors. Cox proportional hazards models were used for analysis.Results: Of 381 278 ACS patients, 332 338 (87.2%) were treated with clopidogrel, 5312 (1.4%) with prasugrel, and 43 628 (11.4%) with ticagrelor. After propensity score matching, prasugrel and ticagrelor reduced mortality compared with clopidogrel (hazard ratios 1.69 and 1.72, respectively; P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://journals.viamedica.pl/polish_heart_journal/article/downloadSuppFile/107718/484885; https://journals.viamedica.pl/polish_heart_journal/article/downloadSuppFile/107718/484887; https://journals.viamedica.pl/polish_heart_journal/article/view/107718 |
| DOI: |
10.33963/v.phj.107718 |
| Availability: |
https://journals.viamedica.pl/polish_heart_journal/article/view/107718; https://doi.org/10.33963/v.phj.107718 |
| Rights: |
The copyright to the submitted manuscript is held by the Author, who grants the Polish Cardiac Society a nonexclusive licence to use, reproduce, and distribute the work, including for commercial purposes. Polish Heart Journal (Kardiologia Polska) is an open access journal that applies the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (CC BY-NC-ND 4.0), allowing third parties to download articles and share them with others, provided the original work is properly cited, not changed in any way, distributed under the same licence, and used for non-commercial purposes only. For commercial use, please contact the journal office: polishheartjournal@ptkardio.pl. If submitted work has been funded by institutional grant, the applicant may optionally choose to release the work under Creative Commons licence: attribution (CC BY) to meet the requirements of funding party, if applicable. Licence Terms can be downloaded here. ; Przesyłając manuskrypt wraz z ilustracjami i tabelami, automatycznie i nieodpłatnie przenosi (przenoszą) na Polskie Towarzystwo Kardiologiczne wszelkie prawa autorskie do wydawania oraz rozpowszechniania nadesłanych materiałów we wszystkich znanych formach i na wszystkich znanych polach eksploatacji, bez ograniczeń terytorialnych językowych pod warunkiem, że materiały te zostaną zaakceptowane do publikacji. |
| Accession Number: |
edsbas.767BC5B7 |
| Database: |
BASE |