| Title: |
NK cells link immune-checkpoint blockade immunotherapy and response in melanoma brain metastases |
| Authors: |
Kohanbash, Gary; Frederico, Stephen C.; Raphael, Itay |
| Source: |
Journal for ImmunoTherapy of Cancer ; volume 13, issue 3, page e011581 ; ISSN 2051-1426 |
| Publisher Information: |
BMJ |
| Publication Year: |
2025 |
| Description: |
Melanoma brain metastases (BMs) pose a significant clinical challenge. This commentary highlights the emerging understanding of the mechanisms behind immune-checkpoint blockade (ICB) efficacy in melanoma BMs. Specifically, we focus on a recent study by Fife et al , which revealed a non-canonical role for natural killer (NK) cells in shaping the tumor microenvironment following ICB therapy against melanoma BMs. Instead of direct tumor cell killing, this study demonstrates that ICB triggers NK cell chemokine release, CD8 T cell recruitment and enhanced antitumor immunity. The findings from this study highlight that the ICB mechanisms of action are complex and extend beyond the direct interference of inhibitor receptor–ligand interactions between cytotoxic CD8 T cells and tumor cells. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/jitc-2025-011581 |
| Availability: |
https://doi.org/10.1136/jitc-2025-011581; https://syndication.highwire.org/content/doi/10.1136/jitc-2025-011581 |
| Rights: |
http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.7696FC6C |
| Database: |
BASE |