| Title: |
Resting-State Functional Connectivity in Frontostriatal and Posterior Cortical Subtypes in Parkinson's Disease-Mild Cognitive Impairment. |
| Authors: |
Devignes, Quentin; Bordier, Cecile; Viard, Romain; Defebvre, Luc; Kuchcinski, Gregory; Leentjens, A. F. G.; Lopes, Renaud; Dujardin, Kathy |
| Contributors: |
Lille Neurosciences & Cognition - U 1172 (LilNCog); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Imagerie fonctionnelle et exploration du vivant = Lille in vivo imaging and Functional Exploration - PLBS (LiiFE); Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 (PLBS); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS); Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc); Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille |
| Source: |
MOVEMENT DISORDERS ; https://hal.univ-lille.fr/hal-04474815 ; MOVEMENT DISORDERS, 2022, MOVEMENT DISORDERS, 37 (3), p. 502-512. ⟨10.1002/mds.28888⟩ |
| Publisher Information: |
CCSD |
| Publication Year: |
2022 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
dual syndrome hypothesis; cognitive subtypes; independent component analysis; cognition; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; BackgroundThe “dual syndrome hypothesis” distinguished two subtypes in mild cognitive impairment (MCI) in Parkinson's disease: frontostriatal, characterized by attentional and executive deficits; and posterior cortical, characterized by visuospatial, memory, and language deficits.ObjectiveThe aim was to identify resting-state functional modifications associated with these subtypes.MethodsNinety-five nondemented patients categorized as having normal cognition (n = 31), frontostriatal (n = 14), posterior cortical (n = 20), or mixed (n = 30) cognitive subtype had a 3 T resting-state functional magnetic resonance imaging scan. Twenty-four age-matched healthy controls (HCs) were also included. A group-level independent component analysis was performed to identify resting-state networks, and the selected components were subdivided into 564 cortical regions in addition to 26 basal ganglia regions. Global intra- and inter-network connectivity along with global and local efficiencies was compared between groups. The network-based statistics approach was used to identify connections significantly different between groups. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34918782; PUBMED: 34918782 |
| DOI: |
10.1002/mds.28888 |
| Availability: |
https://hal.univ-lille.fr/hal-04474815; https://doi.org/10.1002/mds.28888 |
| Accession Number: |
edsbas.76A92E99 |
| Database: |
BASE |