| Title: |
Nevirapine Use Is Associated with Higher Bone Mineral Density in HIV-1 Positive Subjects on Long-Term Antiretroviral Therapy |
| Authors: |
COUFFIGNAL, Camille; KOLTA, Sami; FLAMANT, Martin; CAZANAVE, Charles; HAYMANN, Jean-Philippe; MENTRE, France; DUVAL, Xavier; LEPORT, Catherine; RAFFI, Francois; CHÊNE, G.; SALAMON, R.; MOATTI, J.; PIERRET, J.; SPIRE, B.; BRUN-VÉZINET, F.; FLEURY, H.; MASQUELIER, B.; PEYTAVIN, G.; GARRAFFO, R.; COSTAGLIOLA, D.; DELLAMONICA, P.; KATLAMA, C.; MEYER, L.; SALMON, D.; CUZIN, L.; DUPON, M.; LE MOING, V.; MARCHOU, B.; MAY, T.; MORLAT, P.; RABAUD, C.; WALDNER-COMBERNOUX, A.; HARDEL, L.; REBOUD, P.; COUFFIN-CADIERGUES, S.; MARCHAND, L.; ASSUIED, A.; CARRIERI, P.; HABAK, S.; COUTURIER, F.; JADAND, C.; PERRIER, A.; PRÉAU, M.; PROTOPOPESCU, C.; SCHMIT, J.L.; CHENNEBAULT, J.M.; FALLER, J.P.; MAGY-BERTRAND, N.; CHIROUZE, C.; HUMBERT, P.; NEAU, D.; GRANIER, P.; ANSART, S.; VERDON, R.; MERRIEN, D.; CHEVOJON, P.; SOBEL, A.; LEVY, Y.; PIROTH, L.; PERRONNE, C.; FROGUEL, E.; CECCALDI, J.; CHIDIAC, C.; GRÉGOIRE, V.; REYNES, J.; FUZIBET, J.; ARSAC, P.; BOUVET, E.; BRICAIRE, F.; MONSONEGO, J.; GIRARD, P.M.; GUILLEVIN, L.; HERSON, S.; MOLINA, J.M.; PIALOUX, G.; SAIN, O.; SELLIER, P.; ROBLOT, F.; BANI-SADR, F.; MICHELET, C.; LUCHT, F.; DEBORD, C.; MARTIN, T.; DE JAUREGUIBERRY, J.P.; BERNARD, L. |
| Publication Year: |
2020 |
| Subject Terms: |
HIV; bone mineral density; nevirapine; Sciences du Vivant [q-bio]/Médecine humaine et pathologie |
| Description: |
We assessed bone mineral density (BMD) in a cohort of human immunodeficiency virus (HIV)-positive patients after a median of 11 years of combination antiretroviral therapy (cART) and evaluated the respective role of HIV infection and antiretroviral drugs (ARVs). A cross-sectional study of 162 participants (131 male) from the ANRS-C08 cohort was performed with bone dual-energy X-ray absorptiometry (DXA) scans and renal assessment. The window of exposure to ARVs was defined as an exposure of more than six cumulative months during the last 3 years before the DXA evaluation to account for a cumulative exposure that could affect bone remodeling. The association with low BMD (Z-score < -2) was assessed by a multiple logistic regression model. The study population was 50 years (median), hepatitis C virus (HCV) (18%), and hepatitis B virus (HBV) (8%) coinfection with HIV-RNA |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1089/AID.2019.0229 |
| Availability: |
https://oskar-bordeaux.fr/handle/20.500.12278/182406; https://hdl.handle.net/20.500.12278/182406; https://doi.org/10.1089/AID.2019.0229 |
| Rights: |
open ; Pas de Licence CC |
| Accession Number: |
edsbas.76D98F0E |
| Database: |
BASE |