Figure S1-S10 from Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation
| Title: | Figure S1-S10 from Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation |
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| Authors: | Alessio Ugolini; Alessandra De Leo; Xiaoqing Yu; Fabio Scirocchi; Xiaoxian Liu; Barbara Peixoto; Delia Scocozza; Angelica Pace; Michela Perego; Alessandro Gardini; Luca D’Angelo; James K.C. Liu; Arnold B. Etame; Aurelia Rughetti; Marianna Nuti; Antonio Santoro; Michael A. Vogelbaum; Jose R. Conejo-Garcia; Paulo C. Rodriguez; Filippo Veglia |
| Publication Year: | 2025 |
| Collection: | The University of Auckland: Figshare |
| Subject Terms: | Cancer; Cancer Risk Factors; Tumor Biology; Molecular and Cellular Biology; Immuno-oncology; Methods and Technology; CNS Cancers; Gliomas; Glioblastomas; Epigenetics; Histone Modification; Immunology; Tumor immunology animal models; Tumor resistance to immune response; Immunotherapy; Metabolism; Metabolomics; Single Cell Technologies; Tumor Microenvironment; Immune cells and the microenvironment |
| Description: | Supplementary Figure 1. GBM-infiltrating Neutrophils are immunosuppressive cells. Supplementary Figure 2. CD71 identifies a cluster of hypoxic and glycolytic Neutrophils. Supplementary Figure 3. CD71+ Neutrophils are long-lived and mature cells that are found in the hypoxic-glycolytic niches of brain tumors. Supplementary Figure 4. CD71+ Neutrophils are immunosuppressive cells within the GBM TME. Supplementary Figure 5. CD71 expression and the immunosuppressive ability cannot be induced in CD71 − Neutrophils. Supplementary Figure 6. Hypoxic CD71+ Neutrophils are long-lived cells but CD71 is not required for their immunosuppressive ability. Supplementary Figure 7. Hypoxia boosts the glycolytic metabolism of CD71+ Neutrophils. Supplementary Figure 8. Extracellular lactate and histone acetylation are not involved in the regulation of the immunosuppressive ability of hypoxic CD71+ Neutrophils. Supplementary Figure 9. Isosafrole specifically inhibits the immunosuppressive ability of hypoxic CD71+ Neutrophils. Supplementary Figure 10. Human CD71+ neutrophils are glycolytic and immunosuppressive cells. |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| DOI: | 10.1158/2159-8290.29221168 |
| Availability: | https://doi.org/10.1158/2159-8290.29221168; https://figshare.com/articles/journal_contribution/Figure_S1-S10_from_Functional_Reprogramming_of_Neutrophils_within_the_Brain_Tumor_Microenvironment_by_Hypoxia-Driven_Histone_Lactylation/29221168 |
| Rights: | CC BY |
| Accession Number: | edsbas.76E4E264 |
| Database: | BASE |