| Title: |
Impact of catheterization on shear-mediated arterial dilation in healthy young men |
| Authors: |
Tryfonos, A; Cocks, MS; Rasoul, D; Mills, J; Green, DJ; Dawson, EA |
| Publisher Information: |
Springer |
| Publication Year: |
2020 |
| Collection: |
Liverpool John Moores University: LJMU Research Online |
| Subject Terms: |
RC1200 Sports Medicine |
| Description: |
Purpose; Animal studies have shown that endothelial denudation abolishes vasodilation in response to increased shear stress. Interestingly, shear-mediated dilation has been reported to be reduced, but not abolished, in coronary artery disease (CAD) patients following catheterization. However, it is not known whether this resulted from a priori endothelial dysfunction in this diseased population. In this study, we evaluated shear-mediated dilation following catheterization in healthy young men. Methods: Twenty-six (age: 24.4 ± 3.8 years, BMI: 24.3 ± 2.8 kg m−2, VO2peak: 50.5 ± 8.8 ml/kg/min) healthy males underwent unilateral transradial catheterization. Shear-mediated dilation of both radial arteries was measured using flow-mediated dilation (FMD) pre-, and 7 days post-catheterization. Results: FMD was reduced in the catheterized arm [9.3 ± 4.1% to 4.3 ± 4.1% (P < 0.001)] post-catheterization, whereas no change was observed in the control arm [8.4 ± 3.8% to 7.3 ± 3.8% (P = 0.168)]. FMD was completely abolished in the catheterized arm in five participants. Baseline diameter (P = 0.001) and peak diameter during FMD (P = 0.035) were increased in the catheterized arm 7 days post-catheterization (baseline: 2.3 ± 0.3 to 2.6 ± 0.2 mm, P < 0.001, peak: 2.5 ± 0.3 to 2.7 ± 0.3 mm, P = 0.001), with no change in the control arm (baseline: 2.3 ± 0.3 to 2.3 ± 0.3 mm, P = 0.288, peak: 2.5 ± 0.3 to 2.5 ± 0.3 mm, P = 0.608). Conclusion: This is the first study in young healthy individuals with intact a priori endothelial function to provide evidence of impaired shear-mediated dilation following catheterization. When combined with earlier studies in CAD patients, our data suggest the catheterization impairs artery function in humans. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1439-6319 |
| Relation: |
https://researchonline.ljmu.ac.uk/id/eprint/14666/1/Impact%20of%20catheterization%20on%20shear-mediated%20arterial%20dilation%20in%20healthy%20young%20men.pdf; Tryfonos, A, Cocks, MS, Rasoul, D, Mills, J, Green, DJ and Dawson, EA (2020) Impact of catheterization on shear-mediated arterial dilation in healthy young men. European Journal of Applied Physiology, 120 (11). pp. 2525-2532. ISSN 1439-6319 |
| DOI: |
10.1007/s00421-020-04473-8 |
| Availability: |
https://researchonline.ljmu.ac.uk/id/eprint/14666/; https://doi.org/10.1007/s00421-020-04473-8 |
| Rights: |
cc_by |
| Accession Number: |
edsbas.773940F9 |
| Database: |
BASE |