| Title: |
Evolution of equine influenza virus in vaccinated horses |
| Authors: |
Murcia, Pablo R.; Baillie, Gregory J.; Stack, J. Conrad; Jervis, Carley; Elton, Debra; Mumford, Jennifer A.; Daly, Janet M.; Kellam, Paul; Grenfell, Bryan T.; Holmes, Edward C.; Wood, James L.N. |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2013 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Subject Terms: |
horses; equine influenza; vaccines; vaccination; pathogens |
| Description: |
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/713531; Journal of Virology; Volume 87; Issue 8 |
| DOI: |
10.1128/JVI.03379-12 |
| Availability: |
https://doi.org/10.1128/JVI.03379-12; https://nottingham-repository.worktribe.com/file/713531/1/98_Murcia%20et%20al%202013_evolution%20of%20influenza%20in%20vaccinated%20horses.pdf; https://nottingham-repository.worktribe.com/output/713531 |
| Rights: |
openAccess |
| Accession Number: |
edsbas.77B012C |
| Database: |
BASE |