| Title: |
How the cognitive reserve interacts with ß-amyloid deposition in mitigating FDG metabolism: An observational study |
| Authors: |
Elena Carapelle; Laura Serra; Sergio Modoni; Michele Falcone; Carlo Caltagirone; Marco Bozzali; Luigi Maria Specchio; Carlo Avolio |
| Publication Year: |
2017 |
| Collection: |
University of Sussex (US): Figshare |
| Subject Terms: |
Alzheimer disease; cognitive reserve; CSF biomarkers; FDG-PET |
| Description: |
This observational study had the aim to assess the interaction between cognitive reserve (CR) and cerebrospinal fluid ß-amyloid1-42 (Aß1-42) in modulating brain [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) metabolism in patients with moderate Alzheimer disease (AD).Twenty-seven patients with probable AD and 25 neurological normal subjects (NNS) entered the study. All participants had an FDG-PET scan, and AD patients also received a lumbar puncture to measure Aß1-42, 181p-tau, and Tau concentrations. Based on years of formal education, AD patients were classified as highly educated-AD (years of formal education >5) or less educated-AD (years of formal education |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
10779/uos.23453387.v1 |
| Availability: |
https://figshare.com/articles/journal_contribution/How_the_cognitive_reserve_interacts_with_-amyloid_deposition_in_mitigating_FDG_metabolism_An_observational_study/23453387 |
| Rights: |
CC BY-NC-ND 4.0 |
| Accession Number: |
edsbas.77BA837B |
| Database: |
BASE |