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Death in hospital following ICU discharge: insights from the LUNG SAFE study

Title:	Death in hospital following ICU discharge: insights from the LUNG SAFE study
Authors:	Antonio Pesenti; John G Laffey; Laurent Brochard; Andres Esteban; Luciano Gattinoni; Frank van Haren; Marco Ranieri; Gordon Rubenfeld; B Taylor Thompson; Arthur S Slutsky; Fernando Rios; Mohammad Omar Faruq; T Sottiaux; P Depuydt; Fredy S Lora; Cesar Cesar Azevedo; Eddy Fan; Guillermo Bugedo; Haibo Qiu; Marcos Gonzalez; Juan Silesky; Vladimir Cerny; Jonas Nielsen; Manuel Jibaja; Tài Pham; Hermann Wrigge; Dimitrios Matamis; Jorge Luis Ranero; Charles Gomersall; Pravin Amin; S M Hashemian; Kevin Clarkson; Giacomo Bellani; Kiyoyasu Kurahashi; Younsuck Koh; Asisclo Villagomez; Amine Ali Zeggwagh; Leo M Heunks; Jon Henrik Laake; Waqar Kashif; Jorge Synclair; Jose Emmanuel Palo; Antero do Vale Fernandes; Dorel Sandesc; Yaasen Arabi; Vesna Bumbasierevic; Nicolas Nin; Jose A Lorente; Anders Larsson; Lise Piquilloud; Boonsong Patjanasoontorn; Fekri Abroug; Daniel F McAuley; Lia McNamee; Javier Hurtado; Ed Bajwa; Gabriel Démpaire; Guy M Francois; Francesca Rabboni; Fabiana Madotto; Sara Conti; Hektor Sula; Lordian Nunci; Alma Cani; Alan Zazu; Christian Dellera; Carolina S Insaurralde; Risso V Alejandro; Julio Daldin; Mauricio Vinzio; Ruben O Fernandez; Luis P Cardonnet; Lisandro R Bettini; Mariano Carboni Bisso; Emilio M Osman; Mariano G Setten; Pablo Lovazzano; Javier Alvarez; Veronica Villar; Norberto C Pozo; Nicolas Grubissich; Gustavo A Plotnikow; Daniela N Vasquez; Santiago Ilutovich; Norberto Tiribelli; Ariel Chena; Carlos A Pellegrini; María G Saenz; Elisa Estenssoro; Matias Brizuela; Hernan Gianinetto; Pablo E Gomez; Valeria I Cerrato; Marco G Bezzi; Silvina A Borello; Flavia A Loiacono; Adriana M Fernandez; Serena Knowles; Claire Reynolds; Deborah M Inskip; Jennene J Miller; Jing Kong; Christina Whitehead; Shailesh Bihari; Aylin Seven; Amanda Krstevski; Helen J Rodgers; Rebecca T Millar; Toni E Mckenna; Irene M Bailey; Gabrielle C Hanlon; Anders Aneman; Joan M Lynch; Raman Azad; John Neal; Paul W Woods; Brigit L Roberts; Mark R Kol; Helen S Wong; Katharina C Riss; Thomas Staudinger; Xavier Wittebole; Caroline Berghe; Pierre A Bulpa; Alain M Dive; Rik Verstraete; Herve Lebbinck; Pieter Depuydt; Joris Vermassen; Philippe Meersseman; Helga Ceunen; Jonas I Rosa; Daniel O Beraldo; Claudio Piras; Adenilton M Rampinelli; Ñ P Nassar Jr; Sergio Mataloun; Marcelo Moock; Marlus M Thompson; Claudio H Gonçalves; Ana Carolina P Antônio; Aline Ascoli; Rodrigo S Biondi; Danielle C Fontenele; Danielle Nobrega; Vanessa M Sales; Suresh Shindhe; Dk Maizatul Aiman; BPg Hj Ismail; John Laffey; Francois Beloncle; Kyle G Davies; Rob Cirone; Venika Manoharan; Mehvish Ismail; Ewan C Goligher; Mandeep Jassal; Niall D Ferguson; Erin Nishikawa; Areej Javeed; Gerard Curley; Nuttapol Rittayamai; Matteo Parotto; Sangeeta Mehta; Jenny Knoll; Antoine Pronovost; Sergio Canestrini; Alejandro R Bruhn; Patricio H Garcia; Felipe A Aliaga; Pamela A Farías; Jacob S Yumha; Claudia A Ortiz; Javier E Salas; Alejandro A Saez; Luis D Vega; Eduardo F Labarca; Felipe T Martinez; Nicolás G Carreño; Pilar Lora; Haitao Liu; Ling Liu; Rui Tang; Xiaoming Luo; Youzhong An; Huiying Zhao; Yan Gao; Zhe Zhai; Zheng L Ye; Wei Wang; Wenwen Li; Qingdong Li; Ruiqiang Zheng; Wenkui Yu; Juanhong Shen; Xinyu Li; Tao Yu; Weihua Lu; Ya Q Wu; Xiao B Huang; Zhenyang He; Yuanhua Lu; Hui Han; Fan Zhang; Renhua Sun; Hua X Wang; Shu H Qin; Bao H Zhu; Jun Zhao; Jian Liu; Bin Li; Jing L Liu; Fa C Zhou; Qiong J Li; Xing Y Zhang; Zhou Li-Xin; Qiang Xin-Hua; Liangyan Jiang; Yuan N Gao; Xian Y Zhao; Yuan Y Li; Xiao L Li; Chunting Wang; Qingchun Yao; Rongguo Yu; Kai Chen; Huanzhang Shao; Bingyu Qin; Qing Q Huang; Wei H Zhu; Ai Y Hang; Ma X Hua; Yimin Li; Yonghao Xu; Yu D Di; Long L Ling; Tie H Qin; Shou H Wang; Junping Qin; Yi Han; Suming Zhou; Monica P Vargas; Juan I Silesky Jimenez; Manuel A González Rojas; Jaime E Solis-Quesada; Christian M Ramirez-Alfaro; Jan Máca; Peter Sklienka; Jakob Gjedsted; Aage Christiansen; Boris G Villamagua; Miguel Llano; Philippe Burtin; Gautier Buzancais; Pascal Beuret; Nicolas Pelletier; Satar Mortaza; Alain Mercat; Jonathan Chelly; Sébastien Jochmans; Nicolas Terzi; Cédric Daubin; Guillaume Carteaux; Nicolas de Prost; Jean-Daniel Chiche; Fabrice Daviaud; Muriel Fartoukh; Guillaume Barberet; Jerome Biehler; Jean Dellamonica; Denis Doyen; Jean-Michel Arnal; Anais Briquet; Fanny Klasen; Laurent Papazian; Arnaud Follin; Damien Roux; Jonathan Messika; Evangelos Kalaitzis; Laurence Dangers; Alain Combes; Siu-Ming Au; Gaetan Béduneau; Dorothée Carpentier; Elie H Zogheib; Herve Dupont; Sylvie Ricome; Francesco L Santoli; Sebastien L Besset; Philippe Michel; Bruno Gelée; Pierre-Eric Danin; Bernard Goubaux; Philippe J Crova; Nga T Phan; Frantz Berkelmans; Julio C Badie; Romain Tapponnier; Josette Gally; Samy Khebbeb; Jean-Etienne Herbrecht; Francis Schneider; Pierre-Louis M Declercq; Jean-Philippe Rigaud; Jacques Duranteau; Anatole Harrois; Russell Chabanne; Julien Marin; Jean-Michel Constantin; Sandrine Thibault; Mohammed Ghazi; Messabi Boukhazna; Salem Ould Zein; Jack R Richecoeur; Daniele M Combaux; Fabien Grelon; Charlene Le Moal; Elise P Sauvadet; Adrien Robine; Virginie Lemiale; Danielle Reuter; Martin Dres; Alexandre Demoule; Dany Goldgran-Toledano; Loredana Baboi; Claude Guérin; Ralph Lohner; Jens Kraßler; Susanne Schäfer; Kai D Zacharowski; Patrick Meybohm; Andreas W Reske; Philipp Simon; Hans-Bernd F Hopf; Michael Schuetz; Thomas Baltus; Metaxia N Papanikolaou; Theonymfi G Papavasilopoulou; Giannis A Zacharas; Vasilis Ourailogloy; Eleni K Mouloudi; Eleni V Massa; Eva O Nagy; Electra E Stamou; Ellada V Kiourtzieva; Marina A Oikonomou; Luis E Avila; Cesar A Cortez; Johanna E Citalán; Sameer A Jog; Safal D Sable; Bhagyesh Shah; Mohan Gurjar; Arvind K Baronia; Mohammedfaruk Memon; Radhakrishnan Muthuchellappan; Venkatapura J Ramesh; Anitha Shenoy; Ramesh Unnikrishnan; Subhal B Dixit; Rachana V Rhayakar; Nagarajan Ramakrishnan; Vallish K Bhardwaj; Heera L Mahto; Sudha V Sagar; Vijayanand Palaniswamy; Deeban Ganesan; Seyed Mohammadreza Hashemian; Hamidreza Jamaati; Farshad Heidari; Edel A Meaney; Alistair Nichol; Karl M Knapman; Donall O'Croinin; Eimhin S Dunne; Dorothy M Breen; Kevin P Clarkson; Rola F Jaafar; Rory Dwyer; Fahd Amir; Olaitan O Ajetunmobi; Aogan C O'Muircheartaigh; Colin S Black; Nuala Treanor; Daniel V Collins; Wahid Altaf; Gianluca Zani; Maurizio Fusari; Savino Spadaro; CA Volta; Romano Graziani; Barbara Brunettini; Salvatore Palmese; Paolo Formenti; Michele Umbrello; Andrea Lombardo; Elisabetta Pecci; Marco Botteri; Monica Savioli; Alessandro Protti; Alessia Mattei; Lorenzo Schiavoni; Andrea Tinnirello; Manuel Todeschini; Policlinico P Giaccone; Antonino Giarratano; Andrea Cortegiani; Sara Sher; Anna Rossi; Massimo M Antonelli; Luca M Montini; Paolo Casalena; Sergio Scafetti; Giovanna Panarello; Giovanna Occhipinti; Nicolò Patroniti; Matteo Pozzi; Roberto R Biscione; Michela M Poli; Ferdinando Raimondi; Daniela Albiero; Giulia Crapelli; Eduardo Beck; Vincenzo Pota; Vincenzo Schiavone; Alexandre Molin; Fabio Tarantino; Giacomo Monti; Elena Frati; Lucia Mirabella; Gilda Cinnella; Tommaso Fossali; Riccardo Colombo; Pierpaolo Terragni Ilaria Pattarino; Francesco Mojoli; Antonio Braschi; Erika E Borotto; Andrea N Cracchiolo; Daniela M Palma; Francesco Raponi; Giuseppe Foti; Ettore R Vascotto; Andrea Coppadoro; Luca Brazzi; Leda Floris; Giorgio A Iotti; Aaron Venti; Osamu Yamaguchi; Shunsuke Takagi; Hiroki N Maeyama; Eizo Watanabe; Yoshihiro Yamaji; Kazuyoshi Shimizu; Kyoko Shiozaki; Satoru Futami; Sekine Ryosuke; Koji Saito; Yoshinobu Kameyama; Keiko Ueno; Masayo Izawa; Nao Okuda; Hiroyuki Suzuki; Tomofumi Harasawa; Michitaka Nasu; Tadaaki Takada; Fumihito Ito; Shin Nunomiya; Kansuke Koyama; Toshikazu Abe; Kohkichi Andoh; Kohei Kusumoto; Akira Hirata; Akihiro Takaba; Hiroyasu Kimura; Shuhei Matsumoto; Ushio Higashijima; Hiroyuki Honda; Nobumasa Aoki; Hiroshi Imai; Yasuaki Ogino; Ichiko Mizuguchi; Kazuya Ichikado; Kenichi Nitta; Katsunori Mochizuki; Tomoaki Hashida; Hiroyuki Tanaka; Tomoyuki Nakamura; Daisuke Niimi; Takeshi Ueda; Yozo Kashiwa; Akinori Uchiyama; Olegs Sabelnikovs; Peteris Oss; Youssef Haddad; Kong Y Liew; Silvio A Ñamendys-Silva; Yves D Jarquin-Badiola; Luis A Sanchez-Hurtado; Saira S Gomez-Flores; Maria C Marin; Asisclo J Villagomez; Jordana S Lemus; Jonathan M Fierro; Mavy Ramirez Cervantes; Francisco Javier Flores Mejia; Dulce Dector; Dulce M Dector; Daniel R Gonzalez; Claudia R Estrella; Jorge R Sanchez-Medina; Alvaro Ramirez-Gutierrez; Fernando G George; Janet S Aguirre; Juan A Buensuseso; Manuel Poblano; Mohammed V University; Tarek Dendane; Hicham Balkhi; Mina Elkhayari; Nacer Samkaoui; Hanane Ezzouine; Abdellatif Benslama; Mourad Amor; Wajdi Maazouzi; Nedim Cimic; Oliver Beck; Monique M Bruns; Jeroen A Schouten; Myra Rinia; Monique Raaijmakers; Hellen M Van Wezel; Serge J Heines; Ulrich Strauch; Marc P Buise; Fabienne D Simonis; Marcus J Schultz; Jennifer C Goodson; Troy S Browne; Leanlove Navarra; Anna Hunt; Robyn A Hutchison; Mathew B Bailey; Lynette Newby; Colin Mcarthur; Michael Kalkoff; Alex Mcleod; Jonathan Casement; Danielle J Hacking; Finn H Andersen; Merete S Dolva; Jon H Laake; Andreas Barratt-Due; Kim Andre L Noremark; Eldar Søreide; Brit Å Sjøbø; Anne B Guttormsen; Hector H Leon Yoshido; Ronald Zumaran Aguilar; Fredy A Montes Oscanoa; Alain U Alisasis; Joanne B Robles; Rossini Abbie B Pasanting-Lim; Beatriz C Tan; Pawel Andruszkiewicz; Karina Jakubowska; Cristina M Coxo; António M Alvarez; Bruno S Oliveira; Gustavo M Montanha; Nelson C Barros; Carlos S Pereira; António M Messias; Jorge M Monteiro; Ana M Araujo; Nuno T Catorze; Susan M Marum; Maria J Bouw; Rui M Gomes; Vania A Brito; Silvia Castro; Joana M Estilita; Filipa M Barros; Isabel M Serra; Aurelia M Martinho; Dana R Tomescu; Alexandra Marcu; Ovidiu H Bedreag; Marius Papurica; Dan E Corneci; Silvius Ioan Negoita; Evgeny Grigoriev; Alexey I Gritsan; Andrey A Gazenkampf; Ghaleb Almekhlafi; Mohamad M Albarrak; Ghanem M Mustafa; Khalid A Maghrabi; Nawal Salahuddin; Tharwat M Aisa; Ahmed S Al Jabbary; Edgardo Tabhan; Yaseen M Arabi; Olivia A Trinidad; Hasan M Al Dorzi; Edgardo E Tabhan; Stefan Bolon; Oliver Smith; Jordi Mancebo; Hernan Aguirre-Bermeo; Juan C Lopez-Delgado; Francisco Esteve; Gemma Rialp; Catalina Forteza; Candelaria De Haro; Antonio Artigas; Guillermo M Albaiceta; Sara De Cima-Iglesias; Leticia Seoane-Quiroga; Alexandra Ceniceros-Barros; Antonio L Ruiz-Aguilar; Luis M Claraco-Vega; Juan Alfonso Soler; Maria Del Carmen Lorente; Cecilia Hermosa; Federico Gordo; Miryam Prieto-González; Juan B López-Messa; Manuel P Perez; Cesar P Perez; Raquel Montoiro Allue; Ferran Roche-Campo; Marcos Ibañez-Santacruz; Susana Temprano; Maria C Pintado; Raul De Pablo; Pilar Ricart Aroa Gómez; Silvia Rodriguez Ruiz; Silvia Iglesias Moles; Ma Teresa Jurado; Alfons Arizmendi; Enrique A Piacentini; Nieves Franco; Teresa Honrubia; Meisy Perez Cheng; Elena Perez Losada; Javier Blanco; Luis J Yuste; Cecilia Carbayo-Gorriz; Francisca G Cazorla-Barranquero; Javier G Alonso; Rosa S Alda; Ángela Algaba; Gonzalo Navarro; Enrique Cereijo; Esther Diaz-Rodriguez; Diego Pastor Marcos; Laura Alvarez Montero; Luis Herrera Para; Roberto Jimenez Sanchez; Miguel Angel Blasco Navalpotro; Ricardo Diaz Abad; Raquel Montiel Gonz Á Lez; Dácil Parrilla Toribio; Alejandro G Castro; Maria Jose D Artiga; Oscar Penuelas; Tomas P Roser; Moreno F Olga; Elena Gallego Curto; Rocío Manzano Sánchez; Vallverdu P Imma; Garcia M Elisabet; Laura Claverias; Monica Magret; Ana M Pellicer; Lucia L Rodriguez; Jesús Sánchez-Ballesteros; Ángela González-Salamanca; Antonio G Jimenez; Francisco P Huerta; Juan Carlos J Sotillo Diaz; Esther Bermejo Lopez; David D Llinares Moya; Alec A Tallet Alfonso; Palazon Sanchez Eugenio Luis; Palazon Sanchez Cesar; Sánchez I Rafael; Corcoles G Virgilio; Noelia N Recio; Richard O Adamsson; Christian C Rylander; Bernhard Holzgraefe; Lars M Broman; Joanna Wessbergh; Linnea Persson; Fredrik Schiöler; Hans Kedelv; Anna Oscarsson Tibblin; Henrik Appelberg; Lars Hedlund; Johan Helleberg; Karin E Eriksson; Rita Glietsch; Niklas Larsson; Ingela Nygren; Silvia L Nunes; Anna-Karin Morin; Thomas Kander; Anne Adolfsson; Hervé O Zender; Corinne Leemann-Refondini; Souheil Elatrous; Slaheddine Bouchoucha; Imed Chouchene; Islem Ouanes; La Marsa; Asma Ben Souissi; Salma Kamoun; Oktay Demirkiran; Mustafa Aker; Emre Erbabacan; Ilkay Ceylan; Nermin Kelebek Girgin; Menekse Ozcelik; Necmettin Ünal; Basak Ceyda Meco; Onat O Akyol; Suleyman S Derman; Barry Kennedy; Ken Parhar; Latha Srinivasa; Danny McAuley; Phil Hopkins; Clare Mellis; Vivek Kakar; Dan Hadfield; Andre Vercueil; Kaushik Bhowmick; Sally K Humphreys; Andrew Ferguson; Raymond Mckee; Ashok S Raj; Danielle A Fawkes; Philip Watt; Linda Twohey; Rajeev R JhaMatthew Thomas; Alex Morton; Varsha Kadaba; Mark J Smith; Anil P Hormis; Santhana G Kannan; Miriam Namih; Henrik Reschreiter; Julie Camsooksai; Alek Kumar; Szabolcs Rugonfalvi; Christopher Nutt; Orla Oneill; Colette Seasman; Ged Dempsey; Christopher J Scott; Helen E Ellis; Stuart Mckechnie; Paula J Hutton; Nora N Di Tomasso; Michela N Vitale; Ruth O Griffin; Michael N Dean; Julius H Cranshaw; Emma L Willett; Nicholas Ioannou; Sarah Gillis; Peter Csabi; Rosaleen Macfadyen; Heidi Dawson; Pieter D Preez; Alexandra J Williams; Owen Boyd; Laura Ortiz-Ruiz De Gordoa; Jon Bramall; Sophie Symmonds; Simon K Chau; Tim Wenham; Tamas Szakmany; Piroska Toth-Tarsoly; Katie H Mccalman; Peter Alexander; Lorraine Stephenson; Thomas Collyer; Rhiannon Chapman; Raphael Cooper; Russell M Allan; Malcolm Sim; David W Wrathall; Donald A Irvine; Kim S Zantua; John C Adams; Andrew J Burtenshaw; Gareth P Sellors; Ingeborg D Welters; Karen E Williams; Robert J Hessell; Matthew G Oldroyd; Ceri E Battle; Suresh Pillai; Istvan Kajtor; Mageswaran Sivashanmugavel; Sinead C Okane; Adrian Donnelly; Aniko D Frigyik; Jon P Careless; Martin M May; Richard Stewart; T John Trinder; Samantha J Hagan; Matt P Wise; Jade M Cole; Caroline C MacFie; Anna T Dowling; Nicolás Nin; Edgardo Nuñez; Gustavo Pittini; Ruben Rodriguez; María C Imperio; Cristina Santos; Alberto Deicas; Carolina Serra; Aditya Uppalapati; Ghassan Kamel; Valerie M Banner-Goodspeed; Jeremy R Beitler; Satyanarayana Reddy Mukkera; Shreedhar Kulkarni; Jarone Lee; Tomaz Mesar; John O Shinn Iii; Dina Gomaa; Christopher Tainter; Dale J Yeatts; Jessica Warren; Michael J Lanspa; Russel R Miller; Colin K Grissom; Samuel M Brown; Philippe R Bauer; Ryan J Gosselin; Barrett T Kitch; Jason E Cohen; Scott H Beegle; Renaud M Gueret; Aiman Tulaimat; Shazia Choudry; William Stigler; Hitesh Batra; Nidhi G Huff; Keith D Lamb; Trevor W Oetting; Nicholas M Mohr; Claine Judy; Shigeki Saito; Fayez M Kheir; Fayez Kheir; Adam B Schlichting; Angela Delsing; Daniel R Crouch; Mary Elmasri; Dina Ismail; Kyle R Dreyer; Thomas C Blakeman; Rebecca M Baron; Carolina Quintana Grijalba; Peter C Hou; Raghu Seethala; Imo Aisiku; Galen Henderson; Gyorgy Frendl; Sen-Kuang Hou; Robert L Owens; Ashley Schomer; Vesna Bumbasirevic; Bojan Jovanovic; Maja Surbatovic; Milic Veljovic
Contributors:	Pesenti, Antonio; G Laffey, John; Brochard, Laurent; Esteban, Andre; Gattinoni, Luciano; van Haren, Frank; Ranieri, Marco; Rubenfeld, Gordon; Taylor Thompson, B; S Slutsky, Arthur; Rios, Fernando; Omar Faruq, Mohammad; Sottiaux, T; Depuydt, P; S Lora, Fredy; Cesar Azevedo, Cesar; Fan, Eddy; Bugedo, Guillermo; Qiu, Haibo; Gonzalez, Marco; Silesky, Juan; Cerny, Vladimir; Nielsen, Jona; Jibaja, Manuel; Pham, Tài; Wrigge, Hermann; Matamis, Dimitrio; Luis Ranero, Jorge; Gomersall, Charle; Amin, Pravin; M Hashemian, S; Clarkson, Kevin; Bellani, Giacomo; Kurahashi, Kiyoyasu; Koh, Younsuck; Villagomez, Asisclo; Ali Zeggwagh, Amine; M Heunks, Leo; Henrik Laake, Jon; Kashif, Waqar; Synclair, Jorge; Emmanuel Palo, Jose; do Vale Fernandes, Antero; Sandesc, Dorel; Arabi, Yaasen; Bumbasierevic, Vesna; Nin, Nicola; A Lorente, Jose; Larsson, Ander; Piquilloud, Lise; Patjanasoontorn, Boonsong; Abroug, Fekri; F McAuley, Daniel; Mcnamee, Lia; Hurtado, Javier; Bajwa, Ed; Démpaire, Gabriel; M Francois, Guy; Rabboni, Francesca; Madotto, Fabiana; Conti, Sara; Sula, Hektor; Nunci, Lordian; Cani, Alma; Zazu, Alan; Dellera, Christian; S Insaurralde, Carolina; V Alejandro, Risso; Daldin, Julio; Vinzio, Mauricio; O Fernandez, Ruben; P Cardonnet, Lui; R Bettini, Lisandro; Carboni Bisso, Mariano; M Osman, Emilio; G Setten, Mariano; Lovazzano, Pablo; Alvarez, Javier; Villar, Veronica; C Pozo, Norberto; Grubissich, Nicola; A Plotnikow, Gustavo; N Vasquez, Daniela; Ilutovich, Santiago; Tiribelli, Norberto; Chena, Ariel; A Pellegrini, Carlo; G Saenz, María; Estenssoro, Elisa; Brizuela, Matia; Gianinetto, Hernan; E Gomez, Pablo; I Cerrato, Valeria; G Bezzi, Marco; A Borello, Silvina; A Loiacono, Flavia; M Fernandez, Adriana; Knowles, Serena
Publication Year:	2021
Collection:	Università degli Studi di Ferrara: CINECA IRIS
Subject Terms:	Acute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFE
Description:	Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073.
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/33849625; info:eu-repo/semantics/altIdentifier/wos/WOS:000640238900004; volume:25; issue:1; firstpage:144-1; lastpage:144-17; numberofpages:17; journal:CRITICAL CARE; https://hdl.handle.net/11392/2470453
DOI:	10.1186/s13054-021-03465-0
Availability:	https://hdl.handle.net/11392/2470453; https://doi.org/10.1186/s13054-021-03465-0; https://ccforum.biomedcentral.com/articles/10.1186/s13054-021-03465-0
Rights:	info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/
Accession Number:	edsbas.77CB860A
Database:	BASE