| Title: |
Sex differences in cardiovascular complications and mortality in hospital patients with covid-19: registry based observational study |
| Authors: |
Hockham, Carinna; Linschoten, Marijke; Asselbergs, Folkert W; Ghossein, Chahinda; Woodward, Mark; Peters, Sanne AE; Al-Ali, AK; Al-Muhanna, FA; Al-Windy, NYY; Almubarak, YA; Alnafie, AN; Alshahrani, M; Alshehri, AM; Anthonio, RL; Asselbergs, FW; Aujayeb, A; Berg, JM ten; van Boxem, AJM; Captur, G; Caputo, M; Charlotte, N; Dark, P; De Sutter, J; Delsing, CE; Dorman, HGR; Drost, JT; Emans, ME; Ferreira, JB; Gabriel, L; van Gilst, WH; Groenemeijer, BE; Haerkens-Arends, HE; van der Harst, P; Hedayat, B; van der Heijden, DJ; Hellou, E; Hermanides, RS; Ast, JF Hermans-van; van Hessen, MWJ; Heymans, SRB; van der Horst, ICC; van Ierssel, SH; Jewbali, LS; Kearney, MT; van Kesteren, HAM; Kietselaer, BLJH; Koning, AMH; Kopylov, PY; Kuijper, AFM; Kwakkel-vanErp, JM; van der Linden MMJM; Linschoten, M; Linssen, GCM; R, Macias Ruiz; Magdelijns, FJH; Martens, FMAC; McCann, GP; van der Meer, P; Meijs, MFL; Messiaen, P; Monraats, PS; Montagna, L; Moriarty, A; Mosterd, A; Nierop, PR; van Ofwegen-Hanekamp, CEE; Pinto, YM; Poorhosseini, H; Prasad, S; Redón, J; Reidinga, AC; Ribeiro, MIA; Ripley, DP; Salah, R; Saneei, E; Saxena, M; Schaap, J; Schellings, DAAM; Schut, A; Shafiee, A; Shore, AC; Siebelink, HJ; van Smeden, M; Smits, PC; Pisters, R; Tessitore, E; Tieleman, RG; Timmermans, P; Tio, RA; Tjong, FVY; Uil, CA den; Van Craenenbroeck, EM; van Veen HPAA; Veneman, T; Verschure; de Vries, JK; van de Wal, RMA; van de Watering, DJ; Westendorp, ICD; Westendorp, PHM; Weytjens, C; Wierda, E; Williams, B; Woudstra, P; Wu, KW; Zaal, R; Zaman, AG; van derZee, PM |
| Source: |
urn:ISSN:2754-0413 ; BMJ Medicine, 2, 1 |
| Publisher Information: |
BMJ |
| Publication Year: |
2023 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 4206 Public Health; 42 Health Sciences; Infectious Diseases; Clinical Trials and Supportive Activities; Coronaviruses Disparities and At-Risk Populations; Patient Safety; Lung; Heart Disease; Cardiovascular; Emerging Infectious Diseases; Clinical Research; Coronaviruses; Women's Health; Prevention; 6.1 Pharmaceuticals; 4.2 Evaluation of markers and technologies; 3 Good Health and Well Being; COVID-19; cardiology; epidemiology; heart failure; CAPACITY-COVID Collaborative Consortium; anzsrc-for: 32 Biomedical and Clinical Sciences; anzsrc-for: 4206 Public Health; anzsrc-for: 42 Health Sciences |
| Description: |
Objective To assess whether the risk of cardiovascular complications of covid-19 differ between the sexes and to determine whether any sex differences in risk are reduced in individuals with pre-existing cardiovascular disease. Design Registry based observational study. Setting 74 hospitals across 13 countries (eight European) participating in CAPACITY-COVID (Cardiac complicAtions in Patients With SARS Corona vIrus 2 regisTrY), from March 2020 to May 2021 Participants All adults (aged ≥18 years), predominantly European, admitted to hospital with highly suspected covid-19 disease or covid-19 disease confirmed by positive laboratory test results (n=11 167 patients). Main outcome measures Any cardiovascular complication during admission to hospital. Secondary outcomes were in-hospital mortality and individual cardiovascular complications with ≥20 events for each sex. Logistic regression was used to examine sex differences in the risk of cardiovascular outcomes, overall and grouped by pre-existing cardiovascular disease. Results Of 11 167 adults (median age 68 years, 40% female participants) included, 3423 (36% of whom were female participants) had pre-existing cardiovascular disease. In both sexes, the most common cardiovascular complications were supraventricular tachycardias (4% of female participants, 6% of male participants), pulmonary embolism (3% and 5%), and heart failure (decompensated or de novo) (2% in both sexes). After adjusting for age, ethnic group, pre-existing cardiovascular disease, and risk factors for cardiovascular disease, female individuals were less likely than male individuals to have a cardiovascular complication (odds ratio 0.72, 95% confidence interval 0.64 to 0.80) or die (0.65, 0.59 to 0.72). Differences between the sexes were not modified by pre-existing cardiovascular disease; for the primary outcome, the female-to-male ratio of the odds ratio in those without, compared with those with, pre-existing cardiovascular disease was 0.84 (0.67 to 1.07). Conclusions In patients admitted to ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_83703 |
| DOI: |
10.1136/bmjmed-2022-000245 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_83703; https://unsworks.unsw.edu.au/bitstreams/9aabd4a2-9009-42d0-8b59-decf9954a33e/download; https://doi.org/10.1136/bmjmed-2022-000245 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read ; This open access article “Hockham C, Linschoten M, Asselbergs FW on behalf of the CAPACITY-COVID Collaborative Consortium, et al Sex differences in cardiovascular complications and mortality in hospital patients with covid-19: registry based observational study. BMJ Medicine 2023;2:e000245. doi:10.1136/bmjmed-2022-000245” is distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
| Accession Number: |
edsbas.780BCC0C |
| Database: |
BASE |