| Title: |
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes |
| Authors: |
Franceschini, Nora; Giambartolomei, Claudia; de Vries, Paul; Finan, Chris; Bis, Joshua; Huntley, Rachael; Lovering, Ruth; Tajuddin, Salman; Winkler, Thomas; Graff, Misa; Kavousi, Maryam; Dale, Caroline; Smith, Albert; Hofer, Edith; van Leeuwen, Elisabeth; Nolte, Ilja; Lu, Lingyi; Scholz, Markus; Sargurupremraj, Muralidharan; Pitkänen, Niina; Franzén, Oscar; Joshi, Peter; Noordam, Raymond; Marioni, Riccardo; Hwang, Shih-Jen; Musani, Solomon; Schminke, Ulf; Palmas, Walter; Isaacs, Aaron; Correa, Adolfo; Zonderman, Alan; Hofman, Albert; Teumer, Alexander; Cox, Amanda; Uitterlinden, André; Wong, Andrew; Smit, Andries; Newman, Anne; Britton, Annie; Ruusalepp, Arno; Sennblad, Bengt; Hedblad, Bo; Pasaniuc, Bogdan; Penninx, Brenda; Langefeld, Carl; Wassel, Christina; Tzourio, Christophe; Fava, Cristiano; Baldassarre, Damiano; O’leary, Daniel; Teupser, Daniel; Kuh, Diana; Tremoli, Elena; Mannarino, Elmo; Grossi, Enzo; Boerwinkle, Eric; Schadt, Eric; Ingelsson, Erik; Veglia, Fabrizio; Rivadeneira, Fernando; Beutner, Frank; Chauhan, Ganesh; Heiss, Gerardo; Snieder, Harold; Campbell, Harry; Völzke, Henry; Markus, Hugh; Deary, Ian; Jukema, J. Wouter; de Graaf, Jacqueline; Price, Jacqueline; Pott, Janne; Hopewell, Jemma; Liang, Jingjing; Thiery, Joachim; Engmann, Jorgen; Gertow, Karl; Rice, Kenneth; Taylor, Kent; Dhana, Klodian; Kiemeney, Lambertus; Lind, Lars; Raffield, Laura; Launer, Lenore; Holdt, Lesca; Dörr, Marcus; Dichgans, Martin; Traylor, Matthew; Sitzer, Matthias; Kumari, Meena; Kivimaki, Mika; Nalls, Mike; Melander, Olle; Raitakari, Olli; Franco, Oscar; Rueda-Ochoa, Oscar; Roussos, Panos; Whincup, Peter; Amouyel, Philippe; Giral, Philippe; Anugu, Pramod; Wong, Quenna; Malik, Rainer; Rauramaa, Rainer; Burkhardt, Ralph; Hardy, Rebecca; Schmidt, Reinhold; de Mutsert, Renée; Morris, Richard; Strawbridge, Rona; Wannamethee, S. Goya; Hägg, Sara; Shah, Sonia; Mclachlan, Stela; Trompet, Stella; Seshadri, Sudha; Kurl, Sudhir; Heckbert, Susan; Ring, Susan; Harris, Tamara; Lehtimäki, Terho; Galesloot, Tessel; Shah, Tina; de Faire, Ulf; Plagnol, Vincent; Rosamond, Wayne; Post, Wendy; Zhu, Xiaofeng; Zhang, Xiaoling; Guo, Xiuqing; Saba, Yasaman; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes; Giese, Anne-Katrin; van der Laan, Sander; Gretarsdottir, Solveig; Anderson, Christopher; Chong, Michael; Adams, Hieab; Ago, Tetsuro; Almgren, Peter; Ay, Hakan; Bartz, Traci; Benavente, Oscar; Bevan, Steve; Boncoraglio, Giorgio; Brown, Robert; Butterworth, Adam; Carrera, Caty; Carty, Cara; Chasman, Daniel; Chen, Wei-Min; Cole, John; Cotlarciuc, Ioana; Cruchaga, Carlos; Danesh, John; de Bakker, Paul; Destefano, Anita; den Hoed, Marcel; Duan, Qing; Engelter, Stefan; Falcone, Guido; Gottesman, Rebecca; Grewal, Raji; Gustafsson, Stefan; Haessler, Jeffrey; Hassan, Ahamad; Havulinna, Aki; Holliday, Elizabeth; Howard, George; Hsu, Fang-Chi; Hyacinth, Hyacinth; Ikram, M. Arfan; Irvin, Marguerite; Jian, Xueqiu; Jiménez-Conde, Jordi; Johnson, Julie; Kanai, Masahiro; Keene, Keith; Kissela, Brett; Kleindorfer, Dawn; Kooperberg, Charles; Kubo, Michiaki; Lange, Leslie; Langenberg, Claudia; Lee, Jin-Moo; Lemmens, Robin; Leys, Didier; Lewis, Cathryn; Lin, Wei-Yu; Lindgren, Arne; Lorentzen, Erik; Magnusson, Patrik; Maguire, Jane; Manichaikul, Ani; Mcardle, Patrick; Meschia, James; Mosley, Thomas; Ninomiya, Toshiharu; O’donnell, Martin; Pulit, Sara; Rannikmäe, Kristiina; Reiner, Alexander; Rexrode, Kathryn; Rich, Stephen; Ridker, Paul; Rost, Natalia; Rothwell, Peter; Rundek, Tatjana; Sacco, Ralph; Sakaue, Saori; Sale, Michele; Salomaa, Veikko; Sapkota, Bishwa; Schmidt, Carsten; Sharma, Pankaj; Slowik, Agnieszka; Sudlow, Cathie; Tanislav, Christian; Tatlisumak, Turgut; Thijs, Vincent; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiedt, Steffen; Walters, Matthew; Wareham, Nicholas; Wassertheil-Smoller, Sylvia; Wiggins, Kerri; Yang, Qiong; Yusuf, Salim; Pastinen, Tomi; Koplev, Simon; Codoni, Veronica; Civelek, Mete; Smith, Nick; Trégouët, David; Christophersen, Ingrid; Roselli, Carolina; Lubitz, Steven; Ellinor, Patrick; Tai, E. Shyong; Kooner, Jaspal; Kato, Norihiro; He, Jiang; van der Harst, Pim; Elliott, Paul; Chambers, John; Takeuchi, Fumihiko; Johnson, Andrew; Sanghera, Dharambir; Jern, Christina; Strbian, Daniel; Fernandez-Cadenas, Israel; Longstreth, W.; Rolfs, Arndt; Hata, Jun; Woo, Daniel; Rosand, Jonathan; Pare, Guillaume; Saleheen, Danish; Stefansson, Kari; Worrall, Bradford; Kittner, Steven; Howson, Joanna; Kamatani, Yoichiro; Dehghan, Abbas; Seldenrijk, Adrie; Morrison, Alanna; Hamsten, Anders; Psaty, Bruce; van Duijn, Cornelia; Lawlor, Deborah; Mook-Kanamori, Dennis; Bowden, Donald; Schmidt, Helena; Wilson, James; Rotter, Jerome; Wardlaw, Joanna; Deanfield, John; Halcox, Julian; Lyytikäinen, Leo-Pekka; Loeffler, Markus; Evans, Michele; Debette, Stéphanie; Humphries, Steve; Völker, Uwe; Gudnason, Vilmundur; Hingorani, Aroon; Björkegren, Johan; Casas, Juan; O’donnell, Christopher |
| Contributors: |
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); ANR-14-CE12-0016,VASCOGENE,Utilisation de marqueurs génétiques des facteurs de risque vasculaire comme outil pour mieux comprendre leur relation avec le déclin cognitif et la démence en population générale(2014) |
| Source: |
ISSN: 2041-1723. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2018 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Abstract Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4 . LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41467-018-07340-5 |
| Availability: |
https://hal.science/hal-04178654; https://doi.org/10.1038/s41467-018-07340-5 |
| Accession Number: |
edsbas.781BA387 |
| Database: |
BASE |