| Title: |
Neuroprotective Effect of Ginkgo biloba and L-Ascorbic Acid on Mercury Chloride (HgCl2)-Induced Oxidative stress and Neuroinflammation in Adult Male Wistar Rats |
| Authors: |
Auza, Moses Ibrahim; Abraham, Sunday Musa; Oladele, Sunday B.; Bauchi, Zainab M.; Danborno, Angela M. |
| Source: |
Biological Sciences; Vol. 4 No. 3 (2024): Volume 4, Issue 3 (September); 701-711 ; 2583-1399 |
| Publisher Information: |
IR Research Publication |
| Publication Year: |
2024 |
| Subject Terms: |
Ginkgo biloba; Mercury Chloride; Ascorbic acid; Oxidative stress; Neurotoxicity; Inflammation |
| Description: |
Mercury chloride (HgCl2) toxicity poses significant health risks upon exposure. Chronic exposure can lead to severe neurological damage. Ginkgo biloba extract (EGB761) enhance cognitive function and memory. Ascorbic acid is a powerful antioxidant that helps protect cells from damage by free radicals. The present study evaluates the effects of EGB761 and L-Ascorbic Acid on HgCl2-Induced Oxidative Stress and Neuroinflammation. 48 adult Wistar rats were randomly divided into 6 groups of 8 rats each. The control group received distilled water. HgCl2 Only received (5 mg/kg HgCl2), HgCl2 + A. A received (5 mg/kg HgCl2 + 100 mg/kg A. A, HgCl2 + A. A received (5 mg/kg HgCl2 + 500 mg/kg A. A, HgCl2 + EGB761 received (5 mg/kg HgCl2 + 100 mg/kg EGB761, and HgCl2+ EGB761 received (5 mg/kg HgCl2 + 500 mg/kg EGB761. All administration was done orally for 21 days. The animals were subjected to a Y maze test and sacrificed on day 22. The brain was excised, and 1 g of tissue homogenized and utilized to assay for (MDA, SOD, CAT, GSH) and (TNF- α, and IL-6) activity. The result showed significant (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://irrespub.com/biolsciences/index.php/1/article/view/197/98; https://irrespub.com/biolsciences/index.php/1/article/view/197 |
| DOI: |
10.55006/biolsciences.2024.4301 |
| Availability: |
https://irrespub.com/biolsciences/index.php/1/article/view/197; https://doi.org/10.55006/biolsciences.2024.4301 |
| Rights: |
Copyright (c) 2024 Moses Ibrahim Auza, Sunday Musa Abraham, Sunday B. Oladele, Zainab M. Bauchi, Angela M. Danborno ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.7835FB5A |
| Database: |
BASE |