Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis
| Title: | Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis |
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| Authors: | Grieger JA; Takele WW; Vesco KK; Redman LM; Hannah W; Bonham MP; Chen M; Chivers SC; Fawcett AJ; Habibi N; Liu K; Mekonnen EG; Pathirana M; Quinteros A; Taylor R; Ukke GG; Zhou SJ; Franks PW; Rich SS; Wagner R; Vilsboll T; Udler MS; Tuomi T; Sweeting A; Sims EK; Sherr JL; Semple RK; Reynolds RM; Redondo MJ; Pratley RE; Pop-Busui R; Pollin TI; Perng W; Pearson ER; Ozanne SE; Owen KR; Oram R; Murphy R; Mohan V; Misra S; Meigs JB; Mathioudakis N; Mathieu C; Ma RCW; Loos RJF; Laffel LM; Kwak SH; Josefson JL; Hood KK; Hivert M-F; Hirsch IB; Hattersley AT; Griffin K; Greeley SAW; Gottlieb PA; Gomez MF; Gloyn AL; Florez JC; Dennis JM; Costacou T; Boyle K; Billings LK; Brown RJ; Philipson LH; Nolan JJ; Eckel RH; Sherifali D; Mixter E; Gruber C; de Souza R; Auh S; Zhu Y; Zhang C; Saint-Martin C; Provenzano M; Pomares-Millan H; Njolstad PR; Nakabuye M; Molnes J; McGovern A; Maloney KA; Flanagan SE; de Franco E; Aukrust I; Polak M; Beltrand J; Zhang Y; Yu G; White SL; Wentworth JM; Vatier C; Van der Schueren B; Urazbayeva M; Tye SC; Stoy J; Stefan N; Steck AK; Steenackers N; Stanislawski MA; Speake C; Sheu WH-H; Selvin E; Scholtens DM; Monaco GSF; Sarkar S; Kanbour S; Santhakumar V; Saeed Z; Ried-Larsen M; Ray D; Jain R; Powe CE; Petrie JR; Perez D; Pazmino S; Pankow JS; Onengut-Gumuscu S; Motala AA; Morton RW; Lowe WL; Long SA; Libman IM; Leung GKW; Leong A; Koivula RW; Jones AG; Johnson RK; Hoag B; Ismail HM; Harris-Kawano A; Huang C; Hansen T; Guasch-Ferre M; Goodarzi MO; Gitelman SE; Fitzpatrick SL; Fitipaldi H; Fernandez-Balsells MM; Evans-Molina C; Dudenhoffer-Pfeifer M; DiMeglio LA; Dickens LT; Deutsch AJ; Dawed AY; Dabelea D; Clemmensen C; Chikowore T; Cheng F; Andersen MK; Amouyal C; Young K; Yamamoto JM; Wong JJ; Wang CC; Wallace AS; Tosur M; Thuesen ACB; Tam CH-T; Svalastoga P; Sevilla-Gonzalez M; Semnani-Azad Z; Schon M; Rooney MR; Raghavan S; Prystupa K; Pilla SJ; Patel KA; Ozkan B; Naylor RN; Most J; Morieri ML; Miller RG; Mclennan N-M; Massey R; Mannisto JME; Lim L-L; Kreienkamp RJ; Kettunen JLT; Kahkoska AR; Jacobsen LM; Ikle JM; Hughes A; Haider E; Gaillard R; Gingras V; Gillard P; Francis EC; Felton JL; Duan D; Cromer SJ; Corcoy R; Colclough K; Clark AL; Bodhini D; Benham JL; Aiken C; Ahmad A; Merino J; Tobias DK; Josefson J; Lim S |
| Source: | Communications Medicine, December 2025 |
| Publisher Information: | Springer Nature |
| Publication Year: | 2025 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © The Author(s) 2025. Background: Precision prevention involves tailoring interventions to the unique characteristics of a group or individual to maximize their effectiveness. In this study, we examined the role of participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain (GWG). Methods: We searched Medline, Embase, and PubMed, from inception up to March 2025, to identify randomized and non-randomized controlled trials of lifestyle interventions (diet, physical activity, or combined) commencing before or during pregnancy. Participant characteristics, including age, race/ethnicity, body mass index (BMI), employment status, fasting low- and high-density lipoprotein cholesterol (HDL-C) were assessed. Mean differences (MD) in GWG were pooled using the random-effect model. Meta-regression and subgroup analysis were conducted by participant characteristics (e.g., BMI). Results: A total of 86 studies with 28,270 participants were included in this systematic review and meta-analysis. All lifestyle intervention types significantly reduced GWG. Combined lifestyle interventions initiated at first (MD −0.68; 95% confidence interval [CI]: −1.28, −0.07) and early second (13–17 weeks) trimester (MD −0.83; 95% CI: −1.46, −0.20) provide better effectiveness in optimizing GWG. Diet-only interventions significantly reduced GWG only in participants with normal BMI (MD −1.33 kg; CI: −1.75, −1.91) compared to the other BMI categories. Combined diet and physical activity interventions reduce excessive GWG in women with higher baseline HDL-C (β −0.04; 95% CI −0.06, −0.01). Conclusions: Lifestyle interventions reduced excessive GWG, with possible differential effects by intervention initiation time, BMI, and HDL-C. Future studies should consider physiological as well as social characteristics, in line with a holistic framework for precision medicine. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/308886; https://eprints.ncl.ac.uk/fulltext.aspx?url=308886/6AF1FAD7-7418-4765-BF36-66303450B1DB.pdf&pub_id=308886 |
| Availability: | https://eprints.ncl.ac.uk/308886 |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.783B6BAA |
| Database: | BASE |