| Title: |
One-Year Sequelae and Quality of Life in Adults with Meningococcal Meningitis: Lessons from the COMBAT Multicentre Prospective Study |
| Authors: |
Duval, Xavier; Taha, Muhamed-Kheir; Lamaury, Isabelle; Escaut, Lélia; Gueit, Isabelle; Manchon, Pauline; Tubiana, Sarah; Hoen, Bruno; Mourvillier, Bruno; Ploy, Marie-Cécile; Varon, Emmanuelle; Caron, François; Bollaert, Pierre-Edouard; Gaillot, Olivier; Poyart, Claire; Bonacorsi, Stephane; Vandenesch, François; Cambau, Emmanuelle; Lecuit, Marc; Gravet, Alain; Frachet, Bruno; de Broucker, Thomas; Bruhl, Daniel Levy; Raffi, François; Preau, Marie; Anguel, Nadia; Argaud, Laurent; Arista, Sophie; Armand-Lefevre, Laurence; Balavoine, Stéphanie; Baraduc, Régine; Barnaud, Guilène; Beraud, Guillaume; Bernard, Louis; Bernars, Georges; Bertei, Dominique; Bessede, Emilie; Pomares, Typhaine Billard; Biron, Charlotte; Bland, Stéphane; Boileau, Julien; Boubeau, Patrice; Bourdon, Sandra; Bousquet, Aurore; Boyer, Sophie; Bozorg-Grayeli, Alexis; Bret, Laurent; Bretonniere, Cédric; Bricaire, François; Brocas, Elsa; Brun, Michel; Buret, Jennifer; Burucoa, Christophe; Cabalion, Jean; Cabon, Mathieu; Camuset, Guillaume; Canevet, Christophe; Carricajo, Anne; Castan, Bernard; Caumes, Eric; Cazanave, Charles; Chabrol, Amélie; Challan-Belval, Thibaut; Chanteperdrix-Marillier, Vanessa; Chaplain, Chantal; Charlier-Woerther, Caroline; Chaussade, Hélène; Chirouze, Catherine; Clair, Bernard; Colot, Julien; Conil, Jean-Marie; Cordel, Hugues; Cormier, Philippe; Cousson, Joël; Cronier, Pierrick; Cua, Eric; Dao-Dubremetz, Anne; Dargere, Sylvie; Degand, Nicolas; Dekeyser, Sophie; Delaune, Deborah; Denes, Eric; Dequin, Pierre-Francois; Descamps, Diane; Descloux, Elodie; Desmaretz, Jean-Luc; Diehl, Jean-Luc; Dimet, Jérôme; Duval, Aurélien Dinh Xavier; Fabe, Claude; Faibis, Frédéric; Flateau, Clara; Fonsale, Nathalie; Forestier, Emmanuel; Fortineau, Nicolas; Gagneux-Brunon, Amandine; Garandeau, Caroline; Garcia, Magali; Garot, Denis; Gaudry, Stéphane; Goehringer, François; Gregoire-Faucher, Valérie; Grosset, Marine; Gubavu, Camélia; Guelon, Dominique; Guimard, Thomas; Guinard, Jérôme; Hadou, Tahar; Helene, Jean-Pierre; Henard, Sandrine; Henry, Benoit; Hochart, Anne-Cécile; Illes, Gabriela; Jaffuel, Sylvain; Jarrin, Irène; Jaureguy, Françoise; Joseph, Cédric; Juvin, Marie-Emmanuelle; Kayal, Samer; Kerneis, Solen; Lacassin, Flore; Lanotte, Philippe; Laurens, Etienne; Laurichesse, Henri; Le Brun, Cécile; Le Moing, Vincent; Le Turnier, Paul; Lecuyer, Hervé; Ledru, Sylvie; Legrix, Céline; Lemaignen, Adrien; Lemble, Chantal; Lemee, Ludovic; Lesens, Olivier; Levast, Marion; Lhommet, Claire; Males, Silvija; Malpote, Edith; Martin-Blondel, Guillaume; Marx, Matthieu; Masson, Raphael; Matray, Olivier; Mbadi, Aurore; Mechai, Frédéric; Mellon, Guillaume; Merens, Audrey; Meyohas, Marie Caroline; Michon, Adrien; Yoganaden, Joy Mootien; Morquin, David; Mouly, Stéphane; Mrozek, Natacha; Nguyen, Sophie; Nguyen, Yohan; Ogielska, Maja; Oziol, Eric; Page, Bernard; Patrat-Delon, Solène; Patry, Isabelle; Pechinot, André; Picot, Sandrine; Pierrejean, Denys; Piroth, Lionel; Plassart, Claire; Plessis, Patrice; Portel, Laurent; Poubeau, Patrice; Poupard, Marie; Prazuck, Thierry; Quaesaet, Luc; Ramanantsoa, Adriatsiferana; Rapp, Christophe; Raskine, Laurent; Raymond, Josette; Revest, Matthieu; Riche, Agnès; Robaday-Voisin, Stéphanie; Robin, Frédéric; Romaszko, Jean-Pierre; Rousseau, Florence; Roux, Anne-Laure; Royer, Cécile; Saada, Matthieu; Salmon, Dominique; Saroufim, Carlo; Schmit, Jean Luc; Sebire, Manuela; Segonds, Christine; Sivadon-Tardy, Valérie; Soismier, Nathalie; Son, Olivia; Sunder, Simon; Suy, Florence; Tande, Didier; Tankovic, Jacques; Valin, Nadia; van Grunderbeeck, Nicolas; Verdon, Renaud; Vergnaud, Michel; Vernet-Garnier, Véronique; Vidal, Magali; Vitrat, Virginie; Vittecoq, Daniel; Vuotto, Fanny; Gorenne, Isabelle; Laouenan, Cédric; Marcault, Estelle; Mentre, France; Pasquet, Blandine; Roy, Carine |
| Contributors: |
Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord; Centre d'investigation Clinique CHU Bichat - Épidémiologie clinique (CIC 1425); AP-HP - Hôpital Bichat - Claude Bernard Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM); F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC); Infections Bactériennes Invasives - Invasive Bacterial Infections; Institut Pasteur Paris (IP); CHU Pointe-à-Pitre / Abymes Guadeloupe; Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); CHU Rouen; Normandie Université (NU); ARN bactériens et médecine (BRM); Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; This study was supported by funding from the Assistance Publique Hopitaux de Paris, the French Society of Infectious Diseases, Pfizer and Sanofi. The rapid service and open access fees were funded by Sanofi. |
| Source: |
ISSN: 0741-238X ; Advances in Therapy ; https://univ-rennes.hal.science/hal-03889949 ; Advances in Therapy, 2022, 39 (6), pp.3031-3041. ⟨10.1007/s12325-022-02149-7⟩. |
| Publisher Information: |
CCSD; Springer Verlag (Germany) |
| Publication Year: |
2022 |
| Subject Terms: |
Meningococcal meningitis; Long-term follow-up; France; Community-acquired bacterial meningitis; [SDV]Life Sciences [q-bio] |
| Description: |
Trial registration: ClinicalTrial.Gov identification number NCT01730690. the COMBAT study group ; International audience ; Introduction: COMBAT is a prospective, multicentre cohort study that enrolled consecutive adults with community-acquired bacterial meningitis (CABM) in 69 participating centres in France between February 2013 and July 2015 and followed them for 1 year.Methods: Patients aged at least 18 years old, hospitalised with CABM were followed during their hospitalisation and then contacted by phone 12 months after enrolment. Here we present the prevalence of sequelae at 12 months in a subgroup of patients with meningococcal meningitis.Results: Five of the 111 patients with meningococcal meningitis died during initial hospitalisation and two died between discharge and 12 months, leaving 104 patients alive 1 year after enrolment, 71 of whom provided 12-month follow-up data. The median age was 30.0 years and 54.1% of the patients had no identified risk factor for meningitis. More than 30% reported persistent headache, more than 40% were not satisfied with their sleep and 10% had concentration difficulties. Hearing loss was present in about 15% of the patients and more than 30% had depressive symptoms. About 13% of the patients with a previous professional activity had not resumed work. On the SF-12 Health Survey, almost 50% and 30% had physical component or mental component scores lower than the 25th percentile of the score distribution in the French general population. There was a non-significant improvement in the patients' disability scores from hospital discharge to 12 months (p = 0.16), but about 10% of the patients had residual disability.Conclusions: Although most patients in our cohort survive meningococcal meningitis, the long-term burden is substantial and therefore it is important to ensure a prolonged follow-up of survivors and to promote preventive strategies, including vaccination. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35484469; PUBMED: 35484469 |
| DOI: |
10.1007/s12325-022-02149-7 |
| Availability: |
https://univ-rennes.hal.science/hal-03889949; https://univ-rennes.hal.science/hal-03889949v1/document; https://univ-rennes.hal.science/hal-03889949v1/file/s12325-022-02149-7.pdf; https://doi.org/10.1007/s12325-022-02149-7 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.786CA840 |
| Database: |
BASE |