| Title: |
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth |
| Authors: |
Roark, Ryan S.; Li, Hui; Williams, Wilton B.; Chug, Hema; Mason, Rosemarie D.; Gorman, Jason; Wang, Shuyi; Lee, Fang-Hua; Rando, Juliette; Bonsignori, Mattia; Hwang, Kwan-Ki; Saunders, Kevin O.; Wiehe, Kevin; Moody, M. Anthony; Hraber, Peter T.; Wagh, Kshitij; Giorgi, Elena E.; Russell, Ronnie M.; Bibollet-Ruche, Frederic; Liu, Weimin; Connell, Jesse; Smith, Andrew G.; DeVoto, Julia; Murphy, Alexander I.; Smith, Jessica; Ding, Wenge; Zhao, Chengyan; Chohan, Neha; Okumura, Maho; Rosario, Christina; Ding, Yu; Lindemuth, Emily; Bauer, Anya M.; Bar, Katharine J.; Ambrozak, David; Chao, Cara W.; Chuang, Gwo-Yu; Geng, Hui; Lin, Bob C.; Louder, Mark K.; Nguyen, Richard; Zhang, Baoshan; Lewis, Mark G.; Raymond, Donald D.; Doria-Rose, Nicole A.; Schramm, Chaim A.; Douek, Daniel C.; Roederer, Mario; Kepler, Thomas B.; Kelsoe, Garnett |
| Contributors: |
Howard Hughes Medical Institute; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Simons Foundation; Penn Center for AIDS Research; Intramural Research Program of the Vaccine Research Center; NIH Training Grant in HIV Pathogenesis; The New York State Office of Science, Technology and Academic Research; Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery; Consortium for HIV/AIDS Vaccine Development; Bill and Melinda Gates Foundation |
| Source: |
Science ; volume 371, issue 6525 ; ISSN 0036-8075 1095-9203 |
| Publisher Information: |
American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2021 |
| Description: |
Convergent HIV evolution across species Human immunodeficiency virus (HIV) has a highly diverse envelope protein that it uses to target human cells, and the complexity of the viral envelope has stymied vaccine development. Roark et al. report that the immediate and short-term evolutionary potential of the HIV envelope is constrained because of a number of essential functions, including antibody escape. Consequently, when introduced into humans as HIV or into rhesus macaque monkeys as chimeric simian-human immunodeficiency virus, homologous envelope glycoproteins appear to exhibit conserved patterns of sequence evolution, in some cases eliciting broadly neutralizing antibodies in both hosts. Conserved patterns of envelope variation and homologous B cell responses in humans and monkeys represent examples of convergent evolution that may serve to guide HIV vaccine development. Science , this issue p. eabd2638 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1126/science.abd2638 |
| Availability: |
https://doi.org/10.1126/science.abd2638; https://syndication.highwire.org/content/doi/10.1126/science.abd2638; https://www.science.org/doi/pdf/10.1126/science.abd2638 |
| Accession Number: |
edsbas.78BB0B1E |
| Database: |
BASE |