| Title: |
Population genomics of Plasmodium ovale species in sub-Saharan Africa |
| Authors: |
Carey-Ewend, Kelly; Popkin-Hall, Zachary R.; Simkin, Alfred; Muller, Meredith; Hennelly, Chris; He, Wenqiao; Moser, Kara A.; Gaither, Claudia; Niaré, Karamoko; Aghakanian, Farhang; Feleke, Sindew; Brhane, Bokretsion G.; Phanzu, Fernandine; Kashamuka, Melchior Mwandagalirwa; Aydemir, Ozkan; Sutherland, Colin J.; Ishengoma, Deus S.; Ali, Innocent M.; Ngasala, Billy; Kalonji, Albert; Tshefu, Antoinette; Parr, Jonathan B.; Bailey, Jeffrey A.; Juliano, Jonathan J.; Lin, Jessica T. |
| Source: |
Nature Communications, 15(1) |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2024 |
| Collection: |
Carolina Digital Repository (UNC - University of North Carolina) |
| Subject Terms: |
force; history; reductase gene; parasites; Plasmodium; selection; Asia; population; malaria; malaria parasites; East; control interventions; continent; merozoites; isolates; signature; population genomics; intervention; merozoite surface protein 1 gene; sub-Saharan Africa; malaria control interventions; species; genome; Plasmodium ovale curtisi; differences; sub-Saharan; POC; East Africa; dihydrofolate reductase gene; whole-genome sequencing |
| Description: |
Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we present a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates are predominantly monoclonal (43/45), with their genetic similarity aligning with geography. Pow shows lower average nucleotide diversity (1.8×10−4) across the genome compared to Poc (3.0×10−4) (p < 0.0001). Signatures of selective sweeps involving the dihydrofolate reductase gene have been found in both species, as are signs of balancing selection at the merozoite surface protein 1 gene. Differences in the nucleotide diversity of Poc and Pow may reflect unique demographic history, even as similar selective forces facilitate their resilience to malaria control interventions. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://cdr.lib.unc.edu/downloads/d791sw86w?file=thumbnail; https://cdr.lib.unc.edu/downloads/d791sw86w |
| DOI: |
10.17615/pk8z-wh28 |
| Availability: |
https://doi.org/10.17615/pk8z-wh28; https://cdr.lib.unc.edu/downloads/d791sw86w?file=thumbnail; https://cdr.lib.unc.edu/downloads/d791sw86w |
| Rights: |
http://rightsstatements.org/vocab/InC/1.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.790521C |
| Database: |
BASE |