The Nature of High-Risk Defining Events in Follicular Lymphoma Determines Overall Survival
| Title: | The Nature of High-Risk Defining Events in Follicular Lymphoma Determines Overall Survival |
|---|---|
| Authors: | Tobin, Joshua WD; Chowdhury, Rakin; Salvaris, Ross; Griffin, Alison; Chikatamarla, Venkata; Goh, Amanda; Tong, Tsz Hung; Birks, Callum; Jain, Sanjiv; Goodall, Elizabeth; Sirdesai, Shreerang; Trevis, Thomas; Elizabeth, Steinepreis; Chen, Yiyang; Black, Harrison |
| Publisher Information: | American Society of Hematology |
| Publication Year: | 2023 |
| Collection: | Griffith University: Griffith Research Online |
| Subject Terms: | Biochemistry and cell biology; Cardiovascular medicine and haematology; Paediatrics; Science & Technology; Life Sciences & Biomedicine; Hematology |
| Subject Geographic: | San Diego; USA |
| Time: | 2023-12-09 to 2023-12-12 |
| Description: | Background: A subset of follicular lymphoma (FL) patients will experience a ‘high-risk defining event’ (HRDE) that portends poor survival due to early progression of disease or transformation to diffuse large B cell lymphoma (TFL). Progression of disease within 24 months (POD24) from front-line immunochemotherapy (ICT) identifies patients with a subsequent five-year OS of 50% compared to a reference group of 90% (Casulo et al. JCO 2015). Although a robust surrogate endpoint for OS in clinical trials (Casulo et al. Blood 2022), it remains to be established if the OS of patents is influenced by the nature of the HRDE. In this study, we examined whether characteristics and clinical trajectory of those with relapsed/progressive FL is the same as that of patients experiencing TFL. Methods: We conducted an international retrospective analysis of newly diagnosed FL patients requiring treatment across 14 academic centres between 2002 and 2021 in the era of rituximab and PET-CT staging. Patients were included with grade 1-3A FL requiring first-line (1L) treatment (ICT, rituximab monotherapy or radiotherapy). We excluded patients with untreated FL, de novo TFL and those with |
| Document Type: | conference object |
| Language: | English |
| Relation: | Blood; Annual Meeting Abstracts: 65th ASH Annual Meeting; 65th ASH Annual Meeting; Tobin, JWD; Chowdhury, R; Salvaris, R; Griffin, A; Chikatamarla, V; Goh, A; Tong, TH; Birks, C; Jain, S; Goodall, E; Sirdesai, S; Trevis, T; Elizabeth, S; Chen, Y; Black, H; Broadby, G; Li, L; Gutta, N; Morris, KL; Cochrane, T; Trotman, J; Talaulikar, D; Shortt, J; Hodges, G; Cheah, CY; Barraclough, AA; Manos, K; Johnston, AM; Royle, J; Mondello, P; Ansell, SM; Hapgood, G, The Nature of High-Risk Defining Events in Follicular Lymphoma Determines Overall Survival, Blood, 2023, 142 (Supplement 1), pp. 1671; https://hdl.handle.net/10072/430077 |
| DOI: | 10.1182/blood-2023-185879 |
| Availability: | https://hdl.handle.net/10072/430077; https://doi.org/10.1182/blood-2023-185879 |
| Rights: | open access |
| Accession Number: | edsbas.7932D08E |
| Database: | BASE |