| Title: |
Early childhood weight gain: Latent patterns and body composition outcomes |
| Authors: |
Norris, T; Mansukoski, L; Gilthorpe, MS; Hamer, M; Hardy, R; Howe, LD; Li, L; Ong, KK; Ploubidis, GB; Viner, RM; Johnson, W |
| Source: |
Paediatric and Perinatal Epidemiology (2021) (In press). |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
ALSPAC; body composition; childhood; growth; weight |
| Description: |
BACKGROUND: Despite early childhood weight gain being a key indicator of obesity risk, we do not have a good understanding of the different patterns that exist. OBJECTIVES: To identify and characterise distinct groups of children displaying similar early-life weight trajectories. METHODS: A growth mixture model captured heterogeneity in weight trajectories between 0 and 60 months in 1390 children in the Avon Longitudinal Study of Parents and Children. Differences between the classes in characteristics and body size/composition at 9 years were investigated. RESULTS: The best model had five classes. The "Normal" (45%) and "Normal after initial catch-down" (24%) classes were close to the 50th centile of a growth standard between 24 and 60 months. The "High-decreasing" (21%) and "Stable-high" (7%) classes peaked at the ~91st centile at 12-18 months, but while the former declined to the ~75th centile and comprised constitutionally big children, the latter did not. The "Rapidly increasing" (3%) class gained weight from below the 50th centile at 4 months to above the 91st centile at 60 months. By 9 years, their mean body mass index (BMI) placed them at the 98th centile. This class was characterised by the highest maternal BMI; highest parity; highest levels of gestational hypertension and diabetes; and the lowest socio-economic position. At 9 years, the "Rapidly increasing" class was estimated to have 68.2% (95% confidence interval [CI] 48.3, 88.1) more fat mass than the "Normal" class, but only 14.0% (95% CI 9.1, 18.9) more lean mass. CONCLUSIONS: Criteria used in growth monitoring practice are unlikely to consistently distinguish between the different patterns of weight gain reported here. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10127555/7/Hamer_ppe.12754.pdf; https://discovery.ucl.ac.uk/id/eprint/10127555/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10127555/7/Hamer_ppe.12754.pdf; https://discovery.ucl.ac.uk/id/eprint/10127555/ |
| Rights: |
open |
| Accession Number: |
edsbas.7940CDF6 |
| Database: |
BASE |