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Socioeconomic Deprivation Weighs Heavily on Liver Fibrosis and Mortality After Hepatitis C Cure (ANRS CO22 Hepather).

Title:	Socioeconomic Deprivation Weighs Heavily on Liver Fibrosis and Mortality After Hepatitis C Cure (ANRS CO22 Hepather).
Authors:	Barré, Tangui; Parlati, Lucia; Bourlière, Marc; Ramier, Clémence; Marcellin, Fabienne; Protopopescu, Camelia; Di Beo, Vincent; Moins, Cécile; Dorival, Celine; Nicol, Jérôme; Zucman-Rossi, Jessica; Mathurin, Philippe; Larrey, Dominique; Boursier, Jérôme; Carrat, Fabrice; Carrieri, Patrizia
Contributors:	Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Institut des sciences de la santé publique Marseille (ISSPAM); Hôpital Cochin AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Institut Cochin (IC UM3 (UMR 8104 / U1016)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Hôpital Saint-Joseph Marseille; ANRS - Maladies infectieuses émergentes (ANRS - MIE); Institut National de la Santé et de la Recherche Médicale (INSERM); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité); Hôpital Européen Georges Pompidou APHP (HEGP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO); Physiopathologie des Maladies Inflammatoires de l'Intestin; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé; Service des Maladies de l'Appareil Digestif et de la Nutrition CHRU Lille; Hôpital Claude Huriez Lille; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Hôpital Saint Eloi CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Centre Hospitalier Universitaire d'Angers (CHU Angers); Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH); Université d'Angers (UA); CHU Saint-Antoine AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); ANRS/AFEF Hepather Study group: Laurent Alric, Delphine Bonnet, Virginie Payssan-Sicart, Chloe Pomes, Fabien Zoulim, Marianne Maynard, Roxane Bai, Lucie Hucault, François Bailly, François Raffi, Eric Billaud, David Boutoille, Maeva Lefebvre, Elisabeth André-Garnier, Paul Cales, Isabelle Hubert, Adrien Lannes, Françoise Lunel, Jérôme Boursier, Tarik Asselah, Nathalie Boyer, Nathalie Giuily, Corinne Castelnau, Giovanna Scoazec, Stanislas Pol, Hélène Fontaine, Emilie Rousseaud, Anaïs Vallet-Pichard, Philippe Sogni, Victor de Ledinghen, Juliette Foucher, Jean-Baptiste Hiriart, Jancell M'Bouyou, Marie Irlès-Depé, Marc Bourlière, Si Nafa Si Ahmed, Valérie Oules, Albert Tran, Rodolphe Anty, Eve Gelsi, Régine Truchi, Dominique Thabut, Saloua Hammeche, Joseph Moussali, Xavier Causse, Barbara De Dieuleveult, Brahim Ouarani, Damien Labarrière, Nathalie Ganne, Véronique Grando-Lemaire, Pierre Nahon, Séverine Brulé, Dominique Guyader, Caroline Jezequel, Audrey Brener, Anne Laligant, Aline Rabot, François Habersetzer, Thomas F Baumert, Michel Doffoel, Catherine Mutter, Pauline Simo-Noumbissie, Esma Razi, Jean-Pierre Bronowicki, Hélène Barraud, Mouni Bensenane, Abdelbasset Nani, Sarah Hassani-Nani, Marie-Albertine Bernard, Georges-Philippe Pageaux, Dominique Larrey, Magda Meszaros, Sophie Metivier, Christophe Bureau, Thibault Morales, Jean Marie Peron, Marie Angèle Robic, Thomas Decaens, Marine Faure, Bruno Froissart, Marie-Noelle Hilleret, Jean-Pierre Zarski, Ghassan Riachi, Odile Goria, Fatima Paris, Hélène Montialoux, Vincent Leroy, Giuliana Amaddeo, Anne Varaut, Mélanie Simoes, Rachida Amzal, Olivier Chazouillières, Tony Andreani, Bénédicte Angoulevant, Azeline Chevance, Lawrence Serfaty, Didier Samuel, Teresa Antonini, Audrey Coilly, Jean-Charles Duclos Vallée, Mariagrazia Tateo, Armand Abergel, Maud Reymond, Chanteranne Brigitte, Buchard Benjamin, Léon Muti, Claire Geist, Guillaume Conroy, Raphaëlle Riffault, Isabelle Rosa, Camille Barrault, Laurent Costes, Hervé Hagège, Véronique Loustaud-Ratti, Paul Carrier, Maryline Debette-Gratien, Philippe Mathurin, Guillaume Lassailly, Elise Lemaitre, Valérie Canva, Sébastien Dharancy, Alexandre Louvet, Anne Minello, Marianne Latournerie, Marc Bardou, Thomas Mouillot, Louis D'Alteroche, Didier Barbereau, Charlotte Nicolas, Laure Elkrief, Anaïs Jaillais, Jérôme Gournay, Caroline Chevalier, Isabelle Archambeaud, Sarah Habes, Isabelle Portal, Moana Gelu-Simeon, Eric Saillard, Marie-Josée Lafrance, Lucie Catherine, Fabrice Carrat, Frederic Chau, Céline Dorival, Isabelle Goderel, Clovis Lusivika-Nzinga, Jonathan Bellet, Jessica Chane-Teng, Grégory Pannetier, Jérôme Nicol, Florian Sebal, Rafika Bekhti, Carole Cagnot, Anaïs Boston, Laura Nailler, Guillaume Le Meut, Alpha Diallo, Ventzislava Petrov-Sanchez, Marc Bourlière, Jérôme Boursier, Fabrice Carrat, Patrizia Carrieri, Elisabeth Delarocque-Astagneau, Victor De Ledinghen, Céline Dorival, Hélène Fontaine, Slim Fourati, Chantal Housset, Dominique Larrey, Pierre Nahon, Georges-Philippe Pageaux, Ventzislava Petrov-Sanchez, Stanislas Pol, Mathias Bruyand, Linda Wittkop, Fabien Zoulim, Jessica Zucman-Rossi, Marianne L'hennaff, Michèle Sizorn, Carole Cagnot
Source:	ISSN: 1365-2893 ; Journal of viral hepatitis ; https://hal.science/hal-04701935 ; Journal of viral hepatitis, 2024, Online ahead of print. ⟨10.1111/jvh.14006⟩.
Publisher Information:	CCSD
Publication Year:	2024
Subject Terms:	direct‐acting antivirals; hepatitis C; chronic; liver disease; mortality; socioeconomic status; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Description:	Although Hepatitis C virus (HCV) infection can be cured with direct-acting antivirals (DAA), some cured patients face a serious risk of advanced liver damage and early mortality. In order to avoid these two negative health outcomes, it is important to identify and assess related risk factors. Little is currently known about socioeconomic and behavioural factors in this context. Using data from the ANRS CO22 Hepather cohort, we tested for associations between socioeconomic and behavioural factors and (i) advanced liver fibrosis (defined as an FIB-4 > 3.25) assessed longitudinally using a mixed-effects logistic regression model (both the whole population and stratified on advanced liver fibrosis status at the time of HCV cure) and (ii) all-cause mortality (Cox proportional hazards model), during post-HCV cure follow-up. Among 5833 participants cured of HCV, living in poverty was associated with postcure advanced liver fibrosis in participants without this diagnosis at the time of HCV cure (population attributable fraction-PAF-of 8.6%) and with mortality in the whole study population (PAF of 10.6%). The detrimental effects of unhealthy alcohol use and heavy tobacco smoking, as well as the beneficial effect of living with a stable partner were also highlighted. We highlighted the major role of poverty and behavioural factors in advanced liver fibrosis and all-cause mortality in patients cured of HCV. Encouraging linkage to social support services and healthy behaviours after successful DAA treatment could limit morbidity and increase survival in this population. Clinical Trial Registration: ClinicalTrials.gov: NCT01953458.
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/39252600; PUBMED: 39252600
DOI:	10.1111/jvh.14006
Availability:	https://hal.science/hal-04701935; https://hal.science/hal-04701935v1/document; https://hal.science/hal-04701935v1/file/islandora_171836.pdf; https://doi.org/10.1111/jvh.14006
Rights:	https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess
Accession Number:	edsbas.79452057
Database:	BASE