| Title: |
One-Year Radiologic Progression in Sporadic and Hereditary Cerebral Amyloid Angiopathy |
| Authors: |
van der Plas, Maaike C.; Koemans, Emma A.; Schipper, Manon R.; Voigt, Sabine; Rasing, Ingeborg; van der Zwet, Reinier G.J.; Kaushik, Kanishk; van Dort, Rosemarie; Schriemer, Sanne; van Harten, Thijs W.; van Zwet, Erik; van Etten, Ellis S.; van Osch, Matthias J.P.; Terwindt, Gisela M.; van Walderveen, Marianne; Wermer, Marieke J.H. |
| Source: |
van der Plas, M C, Koemans, E A, Schipper, M R, Voigt, S, Rasing, I, van der Zwet, R G J, Kaushik, K, van Dort, R, Schriemer, S, van Harten, T W, van Zwet, E, van Etten, E S, van Osch, M J P, Terwindt, G M, van Walderveen, M & Wermer, M J H 2025, 'One-Year Radiologic Progression in Sporadic and Hereditary Cerebral Amyloid Angiopathy', Neurology, vol. 104, no. 9, e213546. https://doi.org/10.1212/WNL.0000000000213546 |
| Publication Year: |
2025 |
| Collection: |
University of Groningen research database |
| Description: |
Background and Objectives: Knowledge on the short-term progression of cerebral amyloid angiopathy (CAA) is important for clinical practice and the design of clinical treatment trials. We investigated the 1-year progression of CAA-related MRI markers in sporadic (sCAA) and Dutch-type hereditary (D-CAA). Methods: Participants were included from 2 prospective cohort studies. 3T-MRI was performed at baseline and after 1 year. We assessed macrobleeds, cerebral microbleeds (CMBs), cortical superficial siderosis (cSS), convexity subarachnoid hemorrhages (cSAHs), white matter hyperintensities (WMH), enlarged centrum semiovale perivascular spaces (CSO-EPVS), and visually stimulated blood oxygenation level-dependent (BOLD) fMRI parameters. Progression was defined as increase in number of macrobleeds or CMBs, new focus or extension of cSS, increase in CSO-EPVS category, or volume increase of >10% of WMH. Multivariable regression analyses were performed to determine factors associated with progression and the association between events related to parenchymal injury (cSAH, macrobleeds) and radiologic progression. Results: We included 98 participants (47% women): 55 with sCAA (mean age 70 years), 28 with symptomatic D-CAA (mean age 59 years), and 15 with presymptomatic D-CAA (mean age 45 years). Progression of >1 MRI markers was seen in all 83 (100%) participants with sCAA and symptomatic D-CAA and in 9 (60%) with presymptomatic D-CAA. The number of CMBs showed the largest progression in sCAA (98%; median increase 24) and symptomatic D-CAA (100%; median increase 58). WMH volume (>10% increase in 70%; mean increase 1.2 mL) was most progressive in presymptomatic D-CAA. A decrease in the upslope of the visually evoked BOLD response was observed for most patients. Symptomatic D-CAA status was associated with more overall progression (adjusted odds ratio [aOR] 9.7; 95% CI 1.7-54.2), CMB (adjusted relative risk [aRR] 2.47; 95% CI 1.5-4.1), and WMH volume progression (β 2.52; 95% CI 0.3-4.8). Baseline CMB count (aRR 1.002; ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0028-3878; 1526-632X |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40198864; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/f4ea450a-6a2f-4abe-ab1d-0d736458326d; info:eu-repo/semantics/altIdentifier/pissn/0028-3878; info:eu-repo/semantics/altIdentifier/eissn/1526-632X |
| DOI: |
10.1212/WNL.0000000000213546 |
| Availability: |
https://hdl.handle.net/11370/f4ea450a-6a2f-4abe-ab1d-0d736458326d; https://research.rug.nl/en/publications/f4ea450a-6a2f-4abe-ab1d-0d736458326d; https://doi.org/10.1212/WNL.0000000000213546; https://pure.rug.nl/ws/files/1402699441/One-Year_Radiologic_Progression_in_Sporadic_and_Hereditary_Cerebral_Amyloid_Angiopathy.pdf; https://www.scopus.com/pages/publications/105002734888 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.79566EF4 |
| Database: |
BASE |