| Title: |
Hallmarks of neurodegenerative diseases |
| Authors: |
Wilson, DM; Cookson, MR; Van Den Bosch, L; Zetterberg, H; Holtzman, DM; Dewachter, I |
| Source: |
Cell , 186 (4) pp. 693-714. (2023) |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
DNA and RNA defects; cytoskeletal defects; energy homeostasis; hallmarks; inflammation; neurodegeneration; neurodegenerative disease; protein aggregation; proteostasis; synaptic and neuronal network dysfunction; Humans; Neurodegenerative Diseases; Pathological; Cell Death; Cytoskeleton |
| Description: |
Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks of NDD: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA defects, inflammation, and neuronal cell death. We describe the hallmarks, their biomarkers, and their interactions as a framework to study NDDs using a holistic approach. The framework can serve as a basis for defining pathogenic mechanisms, categorizing different NDDs based on their primary hallmarks, stratifying patients within a specific NDD, and designing multi-targeted, personalized therapies to effectively halt NDDs. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10165783/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10165783/1/1-s2.0-S0092867422015756-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10165783/ |
| Rights: |
open |
| Accession Number: |
edsbas.7980ACAB |
| Database: |
BASE |