| Title: |
Shared Genetics in Celiac Disease and Inflammatory Bowel Disease Specify a Greater Role for Intestinal Epithelial Cells |
| Authors: |
Nathan Vinícius Ribeiro; Sajid Anwar; Sebo Withoff; Iris H. Jonkers |
| Source: |
International Journal of Molecular Sciences ; Volume 26 ; Issue 7 ; Pages: 2982 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2025 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
celiac disease; inflammatory bowel disease; genetics; epithelial cells |
| Subject Geographic: |
agris |
| Description: |
The contribution of genetics to the development of gut-related autoimmune diseases such as celiac disease (CeD) and inflammatory bowel diseases (IBDs) is well-established, especially in immune cells, but pinpointing the significance of genetic variants to other cell types is more elusive. Increasing evidence indicates that intestinal epithelial cells are active players in modulating the immune response, suggesting that genetic variants affecting these cells could change cell behavior during disease. Moreover, fine-mapping genetic variants and causal genes to relevant cell types can help to identify drug targets and develop personalized targeted therapies. In this context, we reviewed the functions of genes in disease-associated loci shared by CeD and IBD that are expressed in epithelial cells and explored their potential impacts. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms26072982 |
| DOI: |
10.3390/ijms26072982 |
| Availability: |
https://doi.org/10.3390/ijms26072982 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.79F677EE |
| Database: |
BASE |