| Title: |
Interactive effects of interferon-gamma functional single nucleotid polymorphism (+874 T/A) with cardiovascular risk factors in coronary heart disease and early myocardial infarction risk |
| Authors: |
Aslan, Eı; Kucukhuseyin, Özlem; Pekkoc-Uyanik, Kc; Ozkara, G; Yılmaz-Aydoğan, Hülya; Akadam-Teker, Ab; Teker, E; Daglar-Aday, Aynur |
| Contributors: |
2345363 |
| Publication Year: |
2020 |
| Subject Terms: |
Clinical Biochemistry; Cancer Research; Molecular Biology; Drug Discovery; Aging; General Biochemistry; Genetics and Molecular Biology; Biochemistry; Structural Biology; Life Sciences; Sitogenetik; Temel Bilimler; Genetics and Molecular Biology (miscellaneous); Moleküler Biyoloji ve Genetik; Yaşam Bilimleri; Yaşam Bilimleri (LIFE); BİYOKİMYA VE MOLEKÜLER BİYOLOJİ |
| Description: |
Atherosclerosis is an inflammatory disease characterized by extensive lipid accumulation in the artery wall. Throughout the atherosclerotic process, interferon-gamma (IFN-gamma), which is an important pro-inflammatory cytokine, plays a central role in atherosclerotic plaque instability and the occurrence of myocardial infarction (MI). In this study, we aimed to investigate the relationship between IFN-gamma +874 T/A (rs2430561) polymorphism and coronary heart disease (CHD) as well as its effects on MI and CHD. Three hundred and ninety patients with CHD (229 with MI, 161 without MI) and 233 healthy controls were screened by the amplification refractory mutation system (ARMS) PCR method for IFN-gamma +874 T/A polymorphism. For MI risk, early adult age was important risk factors and the risk was increased with IFN-gamma +874 T/A polymorphism. IFN-gamma T allele was significantly increased in the CHD patients with age |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
MOLECULAR BIOLOGY REPORTS; vv_1032021; http://hdl.handle.net/20.500.12627/129465; 47; 11; 8397; 8405 |
| DOI: |
10.1007/s11033-020-05877-7 |
| Availability: |
https://hdl.handle.net/20.500.12627/129465; https://doi.org/10.1007/s11033-020-05877-7 |
| Accession Number: |
edsbas.7A414DBD |
| Database: |
BASE |