| Title: |
A CROSS-SECTIONAL EXPLORATORY STUDY OF RAT SARCOMA (RAS) ACTIVATION IN NON-OBESE WOMEN WITH AND WITHOUT POLYCYSTIC OVARY SYNDROME |
| Authors: |
Niinuma, Sara Anjum; Habib, Haniya; Takemoto, Ashleigh Suzu Nishio; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E. |
| Publication Year: |
2026 |
| Collection: |
University of Hull: Repository@Hull |
| Subject Terms: |
polycystic ovary syndrome; PCOS; cardiovascular risk; biomarkers; proteomics; rat sarcoma proteins; Ras; non-obese |
| Description: |
Studies in obese polycystic ovary syndrome (PCOS) have shown growth factors that activate rat sarcoma (Ras) proteins, which regulate intracellular signaling pathways, differ in PCOS; however, it is difficult to account for obesity, insulin resistance, and systemic inflammation that are linked to many of the features found in PCOS. This study explores Ras signaling proteins and related growth factors in non-obese women with and without PCOS. Somascan proteomic analysis of circulating KRas, Ras GTPase-activating protein-1 (RASA1), and 45 growth factor-related proteins that signal through Ras was undertaken in a non-obese population of women with (n=44) and without (n=78) PCOS, groups matched for age and body mass index (BMI), without insulin resistance (HOMAIR) or systemic inflammation (normal CRP; C-reactive protein). There was an increase in the free androgen index (FAI, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://hull-repository.worktribe.com/output/5569128; Excli Journal; Volume 25; Pagination 174-185 |
| DOI: |
10.17179/excli2025-9005 |
| Availability: |
https://hull-repository.worktribe.com/file/5569128/1/Published%20article; https://hull-repository.worktribe.com/output/5569128; https://doi.org/10.17179/excli2025-9005 |
| Rights: |
openAccess ; http://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.7A6E407F |
| Database: |
BASE |