A human pan-disease blood atlas of the circulating proteome
| Title: | A human pan-disease blood atlas of the circulating proteome |
|---|---|
| Authors: | Álvez, María Bueno; Bergström, Sofia; Kenrick, Josefin; Johansson, Emil; Åberg, Mikael; Akyildiz, Murat; Altay, Ozlem; Sköld, Hilda; Antonopoulos, Konstantinos; Apostolakis, Emmanouil; Balcioglu, Yasin Hasan; Bergström, Anna; Bergström, Göran; Björkander, Sophia; Brage, Suzanne Egyhazi; Brodin, Petter; Butler, Lynn; Cajander, Sara; Danielsson, Hanna; Dayangac, Murat; Dinler-Doganay, Gizem; Doğanay, Levent; Enblad, Gunilla; Enblad, Malin; Fagerberg, Linn; Falck-Jones, Sara; Färnert, Anna; Forsberg, Mattias; Gonzalez, Laura; Gummesson, Anders; Gunnarsson, Karin; Gunnarsson, Iva; Gyllensten, Ulf; Hesselager, Göran; Hober, Andreas; Höglund, Martin; Holmqvist, Marie; Horuluoglu, Begum; Hultgren, Rebecka; Iglesias, Maria Jesus; Janols, Helena; Johansson, Fredric; Johnsson, Anette; Klareskog, Lars; Kotol, David; Kull, Inger; Kvarnström, Marika; Lautenbach, Maximilian Julius; Liljedahl, Ulrika; Lindman, Henrik; Lindskog, Cecilia; Lipcsey, Miklos; Lundberg, Ingrid E; Mardinoglu, Adil; Melén, Erik; Meng, Lingqi; Merritt, Anne-Sophie; Mulder, Jan; Nguyen, Mai Thi-Huyen; Nordlund, Jessica; Norrby-Teglund, Anna; Notarnicola, Antonella; Nowak, Piotr; Odeberg, Jacob; Oksvold, Per; Olsson, Tomas; Padyukov, Leonid; Pauksens, Karlis; Piehl, Fredrik; Pin, Elisa; Pontén, Fredrik; Rameika, Natallia; Reepalu, Anton; Roy, Joy; Schwenk, Jochen M; Sen, Meltem; Siika, Antti; Simonson, Oscar E; Sivertsson, Åsa; Sjöblom, Tobias; Sjöstedt, Evelina; Skoglund, Lovisa; Smed-Sörensen, Anna; Sondén, Klara; Sönnerborg, Anders; Stålberg, Karin; Strålin, Kristoffer; Sundén-Cullberg, Jonas; Sundling, Christopher; Sutantiwanichkul, Thanadol; Svedman, Fernanda Costa; Svensson, Mattias; Svenungsson, Elisabet; Lakshmikanth, Tadepally; Tran-Minh, Khue Hua; Türkez, Hasan; Unge, Christian; Venge, Per; Wahren-Herlenius, Marie; Woessmann, Jakob; Yang, Hong; Yeşilkaya, Umit Haluk; Yuan, Meng; Zeybel, Mujdat; Zhang, Cheng; Zhong, Wen; Zwahlen, Martin; von Feilitzen, Kalle; Nilsson, Peter; Edfors, Fredrik; Uhlén, Mathias |
| Source: | Álvez, M B, Bergström, S, Kenrick, J, Johansson, E, Åberg, M, Akyildiz, M, Altay, O, Sköld, H, Antonopoulos, K, Apostolakis, E, Balcioglu, Y H, Bergström, A, Bergström, G, Björkander, S, Brage, S E, Brodin, P, Butler, L, Cajander, S, Danielsson, H, Dayangac, M, Dinler-Doganay, G, Doğanay, L, Enblad, G, Enblad, M, Fagerberg, L, Falck-Jones, S, Färnert, A, Forsberg, M, Gonzalez, L, Gummesson, A, Gunnarsson, K, Gunnarsson, I, Gyllensten, U, Hesselager, G, Hober, A, Höglund, M, Holmqvist, M, Horuluoglu, B, Hultgren, R, Iglesias, M J, Janols, H, Johansson, F, Johnsson, A, Klareskog, L, Kotol, D, Kull, I, Kvarnström, M, Lautenbach, .... |
| Publication Year: | 2025 |
| Collection: | King's College, London: Research Portal |
| Description: | The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0036-8075; 1095-9203 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41066540; info:eu-repo/semantics/altIdentifier/pissn/0036-8075; info:eu-repo/semantics/altIdentifier/eissn/1095-9203 |
| DOI: | 10.1126/science.adx2678 |
| Availability: | https://kclpure.kcl.ac.uk/portal/en/publications/af601a73-7a16-4617-ace9-0f409099a78d; https://doi.org/10.1126/science.adx2678; https://kclpure.kcl.ac.uk/ws/files/354115160/Pan_disease_resource_ver_32_1_.pdf; https://www.scopus.com/pages/publications/105025246161 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.7AAA3F74 |
| Database: | BASE |