| Title: |
Population genomics of post-glacial western Eurasia |
| Authors: |
Allentoft, M. E.; Sikora, M.; Refoyo-Martínez, A.; Irving-Pease, E. K.; Fischer, A.; Barrie, W.; Ingason, A.; Stenderup, J.; Sjögren, K. -G.; Pearson, A.; Sousa, da, Mota, B.; Schulz, Paulsson, B.; Halgren, A.; Macleod, R.; Jørkov, M. L. S.; Demeter, F.; Sørensen, L.; Nielsen, P. O.; Henriksen, R. A.; Vimala, T.; McColl, H.; Margaryan, A.; Ilardo, M.; Vaughn, A.; Fischer, Mortensen, M.; Nielsen, A. B.; Ulfeldt, Hede, M.; Johannsen, N. N.; Rasmussen, P.; Vinner, L.; Renaud, G.; Stern, A.; Jensen, T. Z. T.; Scorrano, G.; Schroeder, H.; Lysdahl, P.; Ramsøe, A. D.; Skorobogatov, A.; Schork, A. J.; Rosengren, A.; Ruter, A.; Outram, A.; Timoshenko, A. A.; Buzhilova, A.; Coppa, A.; Zubova, A.; Silva, A. M.; Hansen, A. J.; Gromov, A.; Logvin, A.; Gotfredsen, A. B.; Henning, Nielsen, B.; González-Rabanal, B.; Lalueza-Fox, C.; McKenzie, C. J.; Gaunitz, C.; Blasco, C.; Liesau, C.; Martinez-Labarga, C.; Pozdnyakov, D. V.; Cuenca-Solana, D.; Lordkipanidze, D. O.; En’shin, D.; Salazar-García, D. C.; Price, T. D.; Borić, D.; Kostyleva, E.; Veselovskaya, E. V.; Usmanova, E. R.; Cappellini, E.; Brinch, Petersen, E.; Kannegaard, E.; Radina, F.; Eylem, Yediay, F.; Duday, H.; Gutiérrez-Zugasti, I.; Merts, I.; Potekhina, I.; Shevnina, I.; Altinkaya, I.; Guilaine, J.; Hansen, J.; Aura, Tortosa, J. E.; Zilhão, J.; Vega, J.; Buck, Pedersen, K.; Tunia, K.; Zhao, L.; Mylnikova, L. N.; Larsson, L.; Metz, L.; Yepiskoposyan, L.; Pedersen, L.; Sarti, L.; Orlando, L.; Slimak, L.; Klassen, L.; Blank, M.; González-Morales, M.; Silvestrini, M.; Vretemark, M.; Nesterova, M. S.; Rykun, M.; Rolfo, M. F.; Szmyt, M.; Przybyła, M.; Calattini, M.; Sablin, M.; Dobisíková, M.; Meldgaard, M.; Johansen, M.; Berezina, N.; Card, N.; Saveliev, N. A.; Poshekhonova, O.; Rickards, O.; Lozovskaya, O. V.; Gábor, O.; Uldum, O. C.; Aurino, P.; Kosintsev, P.; Courtaud, P.; Ríos, P.; Mortensen, P.; Lotz, P.; Persson, P.; Bangsgaard, P.; de, Barros, Damgaard, P.; Vang, Petersen, P.; Martinez, P. P.; Włodarczak, P.; Smolyaninov, R. V.; Maring, R.; Menduiña, R.; Badalyan, R.; Iversen, R.; Turin, R.; Vasilyev, S.; Wåhlin, S.; Borutskaya, S.; Skochina, S.; Sørensen, S. A.; Andersen, S. H.; Jørgensen, T.; Serikov, Y. B.; Molodin, V. I.; Smrcka, V.; Merts, V.; Appadurai, V.; Moiseyev, V.; Magnusson, Y.; Kjær, K. H.; Lynnerup, N.; Lawson, D. J.; Sudmant, P. H.; Rasmussen, S.; Korneliussen, T. S.; Durbin, R.; Nielsen, R.; Delaneau, O.; Werge, T.; Racimo, F.; Kristiansen, K.; Willerslev, E. |
| Source: |
Nature |
| Publisher Information: |
Nature Research |
| Publication Year: |
2024 |
| Collection: |
Ural Federal University (URFU): ELAR / Уральский федеральный университет: электронный архив УрФУ |
| Subject Terms: |
AGRICULTURE; DIPLOIDY; EUROPE; GENOMICS; HUMANS; METAGENOMICS; EURASIA; ANCESTRY; FOREST-STEPPE; GENOTYPE; MESOLITHIC; NEOLITHIC; POPULATION GENETICS; PREHISTORIC; RELATEDNESS; AGRICULTURAL WORKER; ARTICLE; BLACK SEA; DRUG THERAPY; HUMAN; HUNTER-GATHERER; LAKE; MAJOR CLINICAL STUDY; PHARMACOLOGY; POPULATION GENOMICS; RUSSIAN FEDERATION; STEPPE; TURNOVER RATE |
| Description: |
Western Eurasia witnessed several large-scale human migrations during the Holocene1–5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 bp, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 bp, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations. © 2024, The Author(s). ; Marie Skłodowska-Curie Actions of the EU; Swedish Foundation for Humanities and Social Sciences; Kazakhstan–Central Asia; Ural Federal University Program of ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Final; All Open Access; Green Open Access; Hybrid Gold Open Access; http://elar.urfu.ru/handle/10995/141526; 85181851896; 001143579000017 |
| DOI: |
10.1038/s41586-023-06865-0 |
| Availability: |
http://elar.urfu.ru/handle/10995/141526; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181851896&doi=10.1038%2fs41586-023-06865-0&partnerID=40&md5=8e1dcd7ce9e0e1a0ba4bc1a2042313a0; https://www.nature.com/articles/s41586-023-06865-0.pdf; https://doi.org/10.1038/s41586-023-06865-0 |
| Rights: |
info:eu-repo/semantics/openAccess ; cc-by |
| Accession Number: |
edsbas.7AC4C60F |
| Database: |
BASE |