| Title: |
Pre-treatment differential correlation of gene expression and response to topical steroids in eosinophilic esophagitis |
| Authors: |
Dellon, Evan S; Tsai, Yihsuan S; Coffey, Alisha R; Bodwin, Kelly; Sninsky, Jared A; Mosso, Carson N; He, Tianshe M; O’Connor, Kevin A; Selitsky, Sara R; Nobel, Andrew B; Parker, Joel S |
| Source: |
Diseases of the Esophagus, 36(4) |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Collection: |
Carolina Digital Repository (UNC - University of North Carolina) |
| Subject Terms: |
EoE; development cohort; esophageal biopsies; sets; cohort; correlation; baseline gene expression; expression; response; development; steroid responsiveness; cases; corticosteroids; esophageal; baseline; response to topical steroids; expressed genes; threshold; eosinophilic esophagitis; topical corticosteroids; study; predictors; modulation; exploration; clinical trials; independent validation cohort; development set; gene expression; treated with topical corticosteroids; treatment |
| Description: |
Few predictors of response to topical corticosteroid (tCS) treatment have been identified in eosinophilic esophagitis (EoE). We aimed to determine whether baseline gene expression predicts histologic response to tCS treatment for EoE. We analyzed prospectively collected samples from incident EoE cases who were treated with tCS for 8 weeks in a development cohort (prospective study) or in an independent validation cohort (clinical trial). Whole transcriptome RNA expression was determined from a baseline (pre-treatment) RNA-later preserved esophageal biopsy. Baseline expression was compared between histologic responders ( |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://cdr.lib.unc.edu/downloads/v405ss308?file=thumbnail; https://cdr.lib.unc.edu/downloads/v405ss308 |
| DOI: |
10.17615/3k2z-6a74 |
| Availability: |
https://doi.org/10.17615/3k2z-6a74; https://cdr.lib.unc.edu/downloads/v405ss308?file=thumbnail; https://cdr.lib.unc.edu/downloads/v405ss308 |
| Rights: |
http://rightsstatements.org/vocab/InC/1.0/ |
| Accession Number: |
edsbas.7AEA86D5 |
| Database: |
BASE |