| Title: |
The profile of cognitive impairment and hemodynamic compromise in moyamoya:a single-center prospective cohort study |
| Authors: |
Kronenburg, Annick; Deckers, Pieter T.; van den Berg, Esther; van Schooneveld, Monique M.; Vonken, Evert Jan; van der Zwan, Albert; van Berckel, Bart N.M.; Yaqub,Maqsood; Otte, Willem; Klijn, Catharina J.M.; Braun, Kees P.J.; Onderzoek NCH; Brain; Neurochirurgie; Projectafdeling VCI; UMC Utrecht Academie; Psychosociale zorg patientenzorg; Other research (not in main researchprogram); MS Radiologie; Circulatory Health; Neurochirurgen; Onderzoek; Projectafdeling KIND; Projectafdeling CVZ; Neurologen |
| Publication Year: |
2023 |
| Subject Terms: |
cerebral perfusion; cognitive function; determinants; ischemia; moyamoya vasculopathy; neuropsychological evaluation; vascular disorders; Taverne; Clinical Neurology; Surgery; Research Support; Non-U.S. Gov't; Journal Article |
| Description: |
OBJECTIVE Patients with moyamoya vasculopathy often experience cognitive impairments. In this prospective single-center study, the authors investigated the profile of neurocognitive impairment and its relation with the severity of ischemic brain lesions and hemodynamic compromise. METHODS Patients treated in a Dutch tertiary referral center were prospectively included. All patients underwent standardized neuropsychological evaluation, MRI, digital subtraction angiography, and [15O]H2O-PET (to measure cerebrovascular reactivity [CVR]). The authors determined z-scores for 7 cognitive domains and the proportion of patients with cognitive impairment (z-score < −1.5 SD in at least one domain). The authors explored associations between patient characteristics, imaging and CVR findings, and cognitive scores per domain by using multivariable linear regression and Bayesian regression analysis. RESULTS A total of 40 patients (22 children; 75% females) were included. The median age for children was 9 years (range 1–16 years); for adults it was 39 years (range 19–53 years). Thirty patients (75%) had an infarction, and 31 patients (78%) had impaired CVR (steal phenomenon). Six of 7 cognitive domains scored below the population norm. Twenty-nine patients (73%) had cognitive impairment. Adults performed better than children in the cognitive domain visuospatial functioning (p = 0.033, Bayes factor = 4.0), and children performed better in processing speed (p = 0.041, Bayes factor = 3.5). The authors did not find an association between infarction, white matter disease, or CVR and cognitive domains. CONCLUSIONS In this Western cohort, cognitive functioning in patients with moyamoya vasculopathy was below the population norm, and 73% had cognitive impairment in at least one domain. The cognitive profile differed between adults and children. The authors could not find an association with imaging findings. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0022-3085 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/447838 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/447838 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.7AFB7852 |
| Database: |
BASE |