| Title: |
Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels |
| Authors: |
Van Leeuwen,Elisabeth M.; Karssen,Lennart C.; Deelen,Joris; Isaacs,Aaron; Medina-Gomez,Carolina; Mbarek,Hamdi; Kanterakis,Alexandros; Trompet,Stella; Postmus,Iris; Verweij,Niek; Van Enckevort,David J.; Huffman,Jennifer E.; White,Charles C.; Feitosa,Mary F.; Bartz,Traci M.; Manichaikul,Ani; Joshi,Peter K.; Peloso,Gina M.; Deelen,Patrick; Van Dijk,Freerk; Willemsen,Gonneke; De Geus,Eco J.; Milaneschi,Yuri; Penninx,Brenda W J H; Francioli, Laurent C.; Menelaou,Androniki; Pulit, Sara L.; Rivadeneira,Fernando; Hofman,Albert; Oostra,Ben A.; Franco,Oscar H.; Leach,Irene Mateo; Beekman,Marian; De Craen,Anton J M; Uh, Hae Won; Trochet,Holly; Hocking,Lynne J.; Porteous,David J.; Sattar,Naveed; Packard,Chris J.; Buckley,Brendan M.; Brody,Jennifer A.; Bis,Joshua C.; Rotter,Jerome I.; Mychaleckyj,Josyf C.; Campbell,Harry; Duan,Qing; Lange,Leslie A.; Wilson,James F.; Hayward,Caroline; Polasek,Ozren; Vitart,Veronique; Rudan,Igor; Wright,Alan F.; Rich,Stephen S.; Psaty,Bruce M.; Borecki,Ingrid B.; Kearney,Patricia M.; Stott,David J.; Cupples,L. Adrienne; Jukema,J. Wouter; Van Der Harst, Pim; Sijbrands,Eric J.; Hottenga,Jouke Jan; Uitterlinden,Andre G.; Swertz,Morris A.; Van Ommen,Gert Jan B; De Bakker,Paul I W; Eline Slagboom,P.; Boomsma,Dorret I.; Wijmenga,Cisca; Van Duijn,Cornelia M.; Neerincx,Pieter B T; Elbers,Clara C.; Palamara,Pier Francesco; Peer,Itsik; Abdellaoui,Abdel; Kloosterman, Wigard P.; Van Oven,Mannis; Vermaat,Martijn; Li,Mingkun; Laros,Jeroen F J; Stoneking,Mark; De Knijff,Peter; Kayser,Manfred; Veldink, Jan H.; Van Den Berg, Leonard H.; Byelas,Heorhiy; Den Dunnen,Johan T.; Dijkstra,Martijn; Amin,Najaf; Van Der Velde,K. Joeri; Van Setten, Jessica; Kattenberg,Mathijs; Van Schaik,Barbera D C; Bot,Jan; Nijman, Isaäc J.; Mei,Hailiang; Koval,Vyacheslav; Ye,Kai; Lameijer,Eric Wubbo; Moed,Matthijs H.; Hehir-Kwa,Jayne Y.; Handsaker,Robert E.; Sunyaev,Shamil R.; Sohail,Mashaal; Hormozdiari,Fereydoun; Marschall,Tobias; Schönhuth,Alexander; Guryev, Victor; Suchiman,H. Eka D; Wolffenbuttel,Bruce H.; Platteel,Mathieu; Pitts,Steven J.; Potluri,Shobha; Cox,David R.; Li,Qibin; Li,Yingrui; Du,Yuanping; Chen,Ruoyan; Cao,Hongzhi; Li,Ning; Cao,Sujie; Wang,Jun; Bovenberg,Jasper A.; de Bakker, Paul I W; CMM Groep Kaaij; CMM Groep Kloosterman; Child Health; Cancer; ZL Neuromusculaire Ziekten Medisch; Experimentele Afd. Cardiologie 1; CMM Groep Cuppen; JC onderzoeksprogramma Methodology |
| Publication Year: |
2015 |
| Subject Terms: |
General Biochemistry,Genetics and Molecular Biology; General Chemistry; General Physics and Astronomy |
| Description: |
Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (∼35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/333051 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/333051 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.7B294D37 |
| Database: |
BASE |