| Title: |
Perceived triggers of asthma impair quality of life in children with asthma |
| Authors: |
Kansen, Hannah M.; Le, Thuy My; Meijer, Yolanda; Uiterwaal, Cuno S.P.M.; Knulst, André C.; van der Ent, Cornelis K.; van Erp, Francine C.; UMC Utrecht; Longziekten onderzoek 1; MS Dermatologie/Allergologie; Infection & Immunity; Longziekten patientenzorg; Child Health; Cardiovasculaire Epi Team 4; Circulatory Health; JC onderzoeksprogramma Cardiovascular Health; Speerpunt Child Health; Unit Opleiding Dermatologie |
| Publication Year: |
2019 |
| Subject Terms: |
asthma; paediatrics; quality of life; Journal Article |
| Description: |
Background: Data on the impact of the number and nature of perceived asthma triggers on health-related quality of life (HRQL) in children are scarce. Objective: To investigate the impact of perceived asthma triggers on both asthma-specific and generic HRQL in children. Methods: A cross-sectional study was conducted among children (7-18 years) with asthma in secondary and tertiary care. Children were screened with electronic questionnaires regarding respiratory and allergic symptoms. Asthma-specific HRQL was assessed using the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) (score range 1-7) and generic HRQL using the RAND questionnaire (score range 7-32). The Kruskal-Wallis test and one-way ANOVA were used to test the difference of, respectively, the PAQLQ and RAND scores across the number of perceived asthma triggers (0, 1-2, 3-4, or ≥ 5). Univariable and multivariable linear regression analyses were performed to evaluate the association between individual triggers and HRQL. Results: A total of 527 children with a mean (SD) age of 12.1 (2.9) years were included. Children with a higher number of perceived triggers had significantly lower PAQLQ and RAND scores (ie poorer HRQL). The difference in PAQLQ scores was clinically relevant between children with 0 versus 3-4 or ≥ 5 triggers and 1-2 versus ≥ 5 triggers (mean difference 0.66, 1.02 and 0.63, respectively). Especially, non-allergic triggers (physical exercise, the weather, (cigarette) smoke and emotions) were significantly associated with reduced PAQLQ scores. Emotions and food/drinks were associated with reduced RAND scores. Conclusion and Clinical Relevance: A higher number of perceived triggers of asthma were associated with reduced HRQL in children with asthma. Especially, non-allergic triggers were associated with reduced HRQL. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0954-7894 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/391853 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/391853 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.7B8DAD89 |
| Database: |
BASE |