| Title: |
The Utility of Serum Total and Placental Alkaline Phosphatase Activity as Predictive Markers for Preeclampsia among Sudanese Pregnant Women |
| Authors: |
Abdallah, Yusra M; Elfadil, Ghada A Elfadil; Adam, Maazza Omer Adam; Elmugadam, Abdelgadir; Modawe, Gad Allah |
| Source: |
Sudan Medical Laboratory Journal; Vol. 10 No. 2 (2022): Sudan Medical Laboratory Journal ; 45-52 ; 1858-6147 ; 10.52981/smlj.v10i2 |
| Publisher Information: |
Omdurman Islamic University |
| Publication Year: |
2022 |
| Subject Terms: |
Total ALP; PALP; urea; uric acid |
| Description: |
Background: Serum total alkaline phosphatase (TALP) and placenta alkaline phosphatase (PALP) measurement can afford a simple, reliable and economical adjunctive laboratory parameter in hypertensive disorders of pregnancy. Objective: To determine the utility of serum TALP and PALP as predictive markers for preeclampsia among Sudanese pregnant females. Materials and Methods: Cross-sectional comparative hospital-based study conducted in Khartoum state at Omdurman Maternity Hospital from March to June 2022. Hundred Sudanese pregnant women aged ranged between (20 to 45 years), 50 pregnant women with preeclampsia and 50 normal pregnant women as a control group. The serum TALP, and PALP were measured using fully automated analyzer (response® 910), while serum urea, and uric acid were by enzymatic method and creatinine by chemical method. The data obtained were analyzed by using SPSS version (26). Results: Preeclamptic women showed a significant increase in means of serum uric acid (7.4± 2.3 mg/dL VS 3.6± 1.0 mg/dL), urea (33.8± 4.0 mg/dL Vs 17.5 ± 6.2 mg/dL), PALP (151.5± 76.1IU/L VS 111.1±65.4 IU/L, P-value < 0.05) and the ratio of PALP/TALP (0.66 ±0.2 IU/L VS 0.52±0.1 IU/L, P-value< 0.05) compared to normal pregnant women. The Receiver operating characteristics curve (ROC) showed the optimum cut-off value of PALP >133 IU/L and ratio >0.589 as a predictor of preeclampsia among Sudanese pregnant women. Conclusion: Sudanese women with preeclampsia had an elevated serum uric acid, urea, PALP and ratio of PALP/TALP. Moreover, PALP and the ratio of PALP/TALP can be used as a predictive marker of preeclampsia in pregnancy. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://journal.oiu.edu.sd/index.php/mlj/article/view/2847/2155; http://journal.oiu.edu.sd/index.php/mlj/article/view/2847 |
| DOI: |
10.52981/smlj.v10i2.2847 |
| Availability: |
http://journal.oiu.edu.sd/index.php/mlj/article/view/2847; https://doi.org/10.52981/smlj.v10i2.2847 |
| Rights: |
Copyright (c) 2022 Sudan Medical Laboratory Journal |
| Accession Number: |
edsbas.7BAF001E |
| Database: |
BASE |