| Title: |
PNPLA3 I148M (rs738409) genetic variant and age at onset of at‐risk alcohol consumption are independent risk factors for alcoholic cirrhosis |
| Authors: |
Burza, Maria Antonella; Molinaro, Antonio; Attilia, Maria Luisa; Rotondo, Claudia; Attilia, Fabio; Ceccanti, Mauro; Ferri, Flaminia; Maldarelli, Federica; Maffongelli, Angela; De Santis, Adriano; Attili, Adolfo Francesco; Romeo, Stefano; Ginanni Corradini, Stefano |
| Source: |
Liver International ; volume 34, issue 4, page 514-520 ; ISSN 1478-3223 1478-3231 |
| Publisher Information: |
Wiley |
| Publication Year: |
2013 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background & Aims Environmental and genetic factors contribute to alcoholic cirrhosis onset. In particular, age at exposure to liver stressors has been shown to be important in progression to fibrosis in hepatitis C individuals. However, no definite data on the role of age at onset of at‐risk alcohol consumption are available. Moreover, patatin‐like phospholipase domain‐containing protein 3 ( PNPLA 3) I148M (rs738409) variant has been associated with alcoholic cirrhosis, but only in cross‐sectional studies. The aim of this study was to investigate the role of age at onset of at‐risk alcohol consumption and PNPLA 3 I148M variant on alcoholic cirrhosis incidence. Methods A total of 384 at‐risk alcohol drinkers were retrospectively examined. The association among age at onset of at‐risk alcohol consumption, PNPLA 3 I148M variant and cirrhosis incidence was tested. Results A higher incidence of alcoholic cirrhosis was observed in individuals with an older (≥24 years) compared with a younger ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/liv.12310 |
| Availability: |
https://doi.org/10.1111/liv.12310; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fliv.12310; https://onlinelibrary.wiley.com/doi/pdf/10.1111/liv.12310; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/liv.12310 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| Accession Number: |
edsbas.7BB1DBD2 |
| Database: |
BASE |