| Contributors: |
Centre Hospitalier Andrée Rosemon Cayenne, Guyane Française; Santé des populations en Amazonie Cayenne, Guyane française (SPA); Institut Pasteur de la Guyane; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG)-Centre Hospitalier Andrée Rosemon Cayenne, Guyane Française; Croix-Rouge française = French Red Cross; Centre National de Référence des Hantavirus Cayenne, Guyane française (CNR - laboratoire associé); Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur); Biologie des Spirochètes / Biology of Spirochetes; Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047); Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS); Centre National de Référence de la Leptospirose - National Reference Center Leptospirosis (CNR); Institut Pasteur Paris (IP)-Université Paris Cité (UPCité); On-field survey “Enquête autour des cas d’Hantavirus, 2022, Santé publique France” was funded by Santé Publique France. Santé Publique France had a role in study design and data collection. This work was supported by the Agence Nationale de Recherche sur le Sida et les Maladies Infectieuses Emergentes (ANRS/MIE agency) (PLT).; Acknowledgments The authors would like to thank people among Agence Régional de Santé Guyane (Mathilde Ballet, Mathilde Hangard, Alban Lemonnier, Franky Mubenga, Adrien Ortelli, Solène Wiedner-Papin), Institut Pasteur de la Guyane (Damien Donato, Dominique Rousset), Centre National de Référence de la Leptospirose Institut Pasteur de Paris (Pascale Bourhy, Sofia Pombo, Farida Zinini, Céline Lorioux, Jean-François Mariet), La Croix-Rouge francaise (Karl Kpossou, Diana Perez- Aranguena, Luxamarre Saint Hervé, Marckenson Therasse) and Cayenne Hospital (Frédégonde About, Amadou Oury Baldé, Yoris Demars, Olivier Lesens, Camille Meunier, Marina Palomar, Déborah Porez, Mathilde Zenou), Santé Publique France Guyane (Luisiane Carvalho, Sophie Devos, Marion Guyot, Tiphanie Succo), Guyane Promo Santé (Jean-Luc Bau- zat) and others who contributed to the Hantavirus survey and the ancillary study on leptospirosis. The authors acknowl- edge Prof. Maylis Douine (Cayenne University Hospital) for sharing the MAT data of ORPAL1 and ORPAL2 studies. |
| Description: |
International audience ; BackgroundLeptospirosis is a zoonotic disease of increasing importance in French Guiana. It particularly affects subjects living in precarious conditions. We aimed to determine the seroprevalence and the risk of exposure to leptospirosis among inhabitants of three informal settlements in French Guiana.MethodsA serological investigation was conducted in 2022 in three informal settlements in the area of Cayenne, the main city of French Guiana. Leptospirosis exposure factors were assessed in volunteers aged > 15 through a standardized questionnaire. Leptospirosis seroprevalence was evaluated with Microscopic Agglutination Test (MAT) using 17 pathogenic Leptospira antigens with a reactivity threshold of 1:100.ResultsIn 266 participants, median [IQR] age was 42 [34–52] and male to female sex ratio was 0.9. Most participants were migrants (96%), mainly from Haiti (83%), and lived in the study area for at least 2 years (82%). Household rodent exposure (89%) and use of other water sources than collective standpoint (92%) were common. An at-risk occupation was reported for 68% of working participants. Leptospirosis seroprevalence was 7.5% (95% CI [4.7-11.4]) with Ballum and Icterohaemorrhagiae as the main serogroups. Foot skin exposure in wet environments was associated with reactive serum (OR 7.6, 95% CI [1.1 - 326.7]).ConclusionDespite a high theoretical risk of leptospirosis exposure among informal settlements inhabitants, only a few participants were seroreactive for Leptospira. This may suggest that despite at-risk exposures the effective transmission of leptospirosis remains limited within the study area. Broader serological surveys and environmental studies should clarify the areas of at-risk leptospirosis transmission in French Guiana. |