| Title: |
Medication prescription and adherence disparities in non valvular atrial fibrillation patients: an Italian portrait from the ARAPACIS study. |
| Authors: |
RAPARELLI, Valeria; VESTRI, Anna Rita; VIOLI, Francesco; BASILI, Stefania; MORONI, Carlo; PROIETTI, Marco; Buttà, C.; Giosia, P. Di; Sirico, D.; Gobbi, P.; Corrao, S.; Davì, G.; Perticone, F.; Corazza, G. R.; Arapacis, Study Investigators GIS Group |
| Contributors: |
Raparelli, Valeria; Proietti, Marco; Buttà, C.; Giosia, P. Di; Sirico, D.; Gobbi, P.; Corrao, S.; Davì, G.; Vestri, Anna Rita; Perticone, F.; Corazza, G. R.; Violi, Francesco; Basili, Stefania; Arapacis, Study Investigators GIS Group; Moroni, Carlo |
| Publisher Information: |
Springer-Verlag Italia s.r.l. |
| Publication Year: |
2014 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
Antithrombotic; Drugs prescription; Geographical difference; Medication adherence; Non valvular atrial fibrillation; Socioeconomic statu; Emergency Medicine; Internal Medicine |
| Description: |
Non-valvular atrial fibrillation (NVAF) represents a major health-care problem, needing an extensive and strict thrombosis prevention for stroke and cardiovascular (CV) disease risks. NVAF management guidelines recommend adequate antithrombotic and anti-atherosclerotic therapies. Medication adherence has been recognized as a pivotal element in health quality promotion and in the achievement of better clinical outcomes. We conducted a post-hoc analysis of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" with the aim of discerning differences in pharmacological management and medication adherence among NVAF Italian patients. Furthermore, data were analysed according to Italian geographical macro-regions (North, Center, South) to evaluate whether socioeconomic conditions might also influence medication adherence. Thus, we selected 1,366 NVAF patients that fulfilled the Morisky Medication Adherence Scale-4 items. Regional disparities in drug prescriptions were observed. In particular, in high-risk patients (CHA2DS2-VASc ≥2) oral anticoagulants were more prescribed in Northern and Center patients (61 and 60 %, respectively) compared to 53 % of high-risk Southern patients. Also, medication adherence showed a progressive decrease from North to South (78 vs. 60 %, p < 0.001). This disparity was independent of the number of drugs consumed for any reason, since prevalence of poly-therapy among the three macro-regions was similar. Our results show regional differences in NVAF patients' antithrombotic management and medication adherence, potentially reflecting well-known disparities in socioeconomic status among Italian regions. Future interventions promoting campaigns to global health-care education may be desirable to improve clinical outcomes in NVAF patients |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/24990547; info:eu-repo/semantics/altIdentifier/wos/WOS:000345407800006; volume:9; issue:8; firstpage:861; lastpage:870; numberofpages:10; journal:INTERNAL AND EMERGENCY MEDICINE; http://hdl.handle.net/11573/757023 |
| DOI: |
10.1007/s11739-014-1096-1 |
| Availability: |
http://hdl.handle.net/11573/757023; https://doi.org/10.1007/s11739-014-1096-1; http://www.springer.com/italy/home?SGWID=6-102-70-173668106-0&changeHeader=true |
| Accession Number: |
edsbas.7C079046 |
| Database: |
BASE |