| Title: |
Changes in Body Mass Index in Children and Adolescents Living With Human Immunodeficiency Virus in Europe and Thailand Starting Dolutegravir |
| Authors: |
Chappell, Elizabeth; Crichton, Siobhan; Collins, Intira Jeannie; Valle, Giorgia Dalla; Duff, Charlotte; Edgar, Kate; Giaquinto, Carlo; Jackson, Charlotte; Judd, Ali; Mangiarini, Laura; O’Rourke, John; Scott, Karen; Thorne, Claire; Goetghebuer, Tessa; Hainaut, Marc; Tremerie, Wivine; Delforge, Marc; Hoffmann, Thomas Ulrik; Nordly, Sannie Brit; Braun, Marla B; Spoulou, Vana; Galli, Luisa; Chiappini, Elena; Lisi, Catiuscia; Montagnani, Carlotta; Venturini, Elisabetta; Marczyńska, Magdalena; Popielska, Jolanta; Pokorska-Śpiewak, Maria; Ołdakowska, Agnieszka; Zawadka, Konrad; Pluta, Magdalena; Doroba, Małgorzata; Ene, Luminita; Mellado, María José; Escosa, Luis; Hortelano, Milagros García-López; Sainz, Talía; Grasa, Carlos; Rodríguez, Paula; Ramos, Jose Tomás; Rojo, Pablo; Prieto-Tato, Luis; Epalza, Cristina; Tagarro, Alfredo; Domínguez, Sara; Ballesteros, Álvaro; Illán, Marta; Berzosa, Arantxa; Guillén, Sara |
| Contributors: |
ViiV Healthcare; Medical Research Council; Gilead Sciences |
| Source: |
Open Forum Infectious Diseases ; volume 12, issue 12 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Background Excess weight gain has been reported in some adults on dolutegravir (DTG), but data in children/adolescents living with human immunodeficiency virus (CALHIV) are limited. Methods CALHIV aged 2–17 years at DTG start from 15 observational cohorts across Europe and Thailand were included. Mixed models described changes in body-mass-index-for-age z-score (zBMI). We assessed (1) zBMI change 48 weeks before versus after DTG start; (2) zBMI change up to 96 weeks on DTG and associated factors; and (3) zBMI changes over 96 weeks in CALHIV aged 6–17 years at start of DTG versus protease inhibitor (PI)–based regimens using propensity score weighting. Results Of 948 CALHIV on DTG (>99% HIV-1, |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf640 |
| DOI: |
10.1093/ofid/ofaf640/64633143/ofaf640.pdf |
| Availability: |
https://doi.org/10.1093/ofid/ofaf640; https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaf640/64633143/ofaf640.pdf; https://academic.oup.com/ofid/article-pdf/12/12/ofaf640/64633143/ofaf640.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.7C224152 |
| Database: |
BASE |