| Title: |
Antipsychotic medication use and fracture: a case–control study |
| Authors: |
B Azimi Manavi; Amanda Stuart; Julie Pasco; JM Hodge; Dona Kavindi Madushani Weerasinghe; Rasika Samarasinghe; Lana Williams |
| Publication Year: |
2023 |
| Subject Terms: |
Biomedical and clinical sciences; Pharmacology and pharmaceutical sciences; Psychology; Biological psychology; Adult; Antipsychotic Agents; Bone Density; Case-Control Studies; Female; Fractures; Bone; Humans; Life Style; Male |
| Description: |
It has been reported that antipsychotic use is associated with lower bone mineral density and bone quality. We aimed to determine whether antipsychotic use is associated with fracture risk in a population-based sample of adults living in the Barwon Statistical Division, south-eastern Australia. In this case–control study, 1458 participants (51.8% women) with radiologically confirmed fracture between June 1st 2012 and May 31st 2013 (cases) were compared with 1795 participants (46.5% women) without fracture (controls) for the same time period. Medication use, medical history and lifestyle factors were documented by self-report. Multivariable binary logistic regression was used to explore associations between antipsychotic use and fracture following adjustment for possible confounders. In women, antipsychotic use was identified for 20 of 755 (2.6%) cases and 10 of 834 (1.2%) controls (p = 0.034) and in men, antipsychotic use was identified for 13 of 703 (1.8%) cases and 5 of 961 (0.5%) controls (p = 0.010). Following adjustments, antipsychotic use was associated with a 3.0-fold increased risk of fracture in men and a 2.3-fold increased risk of fracture in women. Patterns persisted after exclusion of participants with non-fragility fractures and self-reported schizophrenia. While future research exploring underlying mechanisms is needed, regular monitoring of bone health in antipsychotic users is suggested. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
http://hdl.handle.net/10779/DRO/DU:24226318.v5; https://figshare.com/articles/journal_contribution/Antipsychotic_medication_use_and_fracture_a_case_control_study/24226318 |
| Availability: |
http://hdl.handle.net/10779/DRO/DU:24226318.v5; https://figshare.com/articles/journal_contribution/Antipsychotic_medication_use_and_fracture_a_case_control_study/24226318 |
| Rights: |
CC BY 4.0 |
| Accession Number: |
edsbas.7C58BAFF |
| Database: |
BASE |