| Title: |
Risk of persistent or recurrent cervical neoplasia in patients with ‘pure’ adenocarcinoma‐in‐situ ( AIS) or mixed AIS and high‐grade cervical squamous neoplasia (cervical intra‐epithelial neoplasia grades 2 and 3 ( CIN 2/3)): a population‐based study |
| Authors: |
Codde, E; Munro, A; Stewart, CJR; Spilsbury, K; Bowen, S; Codde, J; Steel, N; Leung, Y; Tan, J; Salfinger, SG; Mohan, GR; Cohen, PA |
| Source: |
BJOG: An International Journal of Obstetrics & Gynaecology ; volume 125, issue 1, page 74-79 ; ISSN 1470-0328 1471-0528 |
| Publisher Information: |
Wiley |
| Publication Year: |
2017 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objective To compare outcomes of patients with pure adenocarcinoma‐in‐situ ( AIS ) and mixed AIS / CIN 2/3 lesions including the incidence of AIS persistence, recurrence and progression to adenocarcinoma. Design Retrospective cohort study. Setting Statewide population in Western Australia. Population Women diagnosed with AIS between 2001 and 2012. Methods We conducted a retrospective, population‐based cohort study. Main outcome measures De‐identified linked data were utilised to ascertain the association between patient age at excisional treatment, margin status, lesion type, lesion size, and risk of persistent AIS (defined as the presence of AIS 30 years ( HR 2.1; 95% CI 1.16–3.81; P = 0.015), positive endocervical margins ( HR 5.8; 95% CI 3.05–10.92; P = 8 mm ( HR 2.5; 95% CI 1.00–6.20; P = 0.049). A histologically positive AIS ectocervical margin was not associated with persistence/recurrence. Conclusion In this study, pure AIS was associated with greater risk of persistence/recurrence than was mixed AIS / CIN 2/3. AIS lesions >8 mm and positive endocervical margins were significant predictors for persistent or recurrent disease. Tweetable Abstract Pure cervical adenocarcinoma‐in‐situ ( AIS ) may have greater risk of recurrence than AIS co‐existing with CIN 2/3. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/1471-0528.14808 |
| Availability: |
https://doi.org/10.1111/1471-0528.14808; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1471-0528.14808; https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0528.14808 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.7C7BFD26 |
| Database: |
BASE |