| Title: |
Lymphoma patients treated with anti-CD20 and chemotherapy display disconnected T and B cell responses to COVID-19 vaccine |
| Authors: |
Lamure, Sylvain; Chavez, Houria Hendel; de Goër de Herve, Marie-Ghislaine; Fornecker, Luc-Matthieu; Drenou, Bernard; Jacquet, Caroline; Merabet, Fatiha; Kohn, Milena; Quélin, Florence; Jackson, Angela; Choquet, Sylvain; Duléry, Rémy; Taoufik, Yassine; Besson, Caroline |
| Source: |
Frontiers in Immunology ; volume 15 ; ISSN 1664-3224 |
| Publisher Information: |
Frontiers Media SA |
| Publication Year: |
2025 |
| Collection: |
Frontiers (Publisher - via CrossRef) |
| Description: |
Due to immunosuppressive treatment, COVID-19 vaccination is challenging in patients with B-cell lymphoma. We prospectively evaluated CD4, CD8 T-cell and serological responses to the COVID-19 mRNA vaccine in a cohort of patients treated for a B-cell lymphoma with anti-CD20 therapy. During lymphoma treatment, CD4, CD8, and CD19 cell dropped. While functional-specific CD4 and CD8 T-cell responses to SARS-CoV-2 were unaffected, vaccination in patients on treatment induced low specific antibody titers, contrasting with a preserved serological response when vaccination was completed before treatment initiation. Those findings reinforce a vaccinal strategy based on completion before lymphoma treatment, with a booster administered afterward. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.3389/fimmu.2024.1524813 |
| DOI: |
10.3389/fimmu.2024.1524813/full |
| Availability: |
https://doi.org/10.3389/fimmu.2024.1524813; https://www.frontiersin.org/articles/10.3389/fimmu.2024.1524813/full |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.7C90C08A |
| Database: |
BASE |