A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study
| Title: | A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study |
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| Authors: | Arpa, Giovanni; Vanoli, Alessandro; Antoci, Francesca; Lenti, Marco Vincenzo; Di Sabatino, Antonio; Small Bowel Carcinoma Consortium Collaborators for their support: Italy: Camilla Guerini (IRCCS San Matteo Hospital Foundation; Pavia); Federica Grillo (Ospedale Policlinico San Martino University Hospital; Genoa); Paola Ilaria Bianchi (IRCCS San Matteo Hospital Foundation; Nicola Aronico (IRCCS San Matteo Hospital Foundation; Laura Libera (Department of Medicine and Surgery and Research Center for the Study of Hereditary and Familial Tumors; Varese); Daniela Furlan (Department of Medicine and Surgery and Research Center for the Study of Hereditary and Familial Tumors; Erica Travaglino (IRCCS San Matteo Hospital Foundation; Gabriella Nesi (Department of Surgery and Translational Medicine; University of Florence; Florence); Gianluca Sampietro (ASST Rhodense; Rho Hospital; Milan); Sandro Ardizzone (Luigi Sacco University Hospital; Paolo Fociani (ASST Ovest Milanese; Roberto Fiocca (Ospedale Policlinico San Martino University Hospital; Giovanni Latella (Department of Life and Environmental Sciences; University of L'Aquila; L'Aquila); Fausto Sessa (Department of Medicine and Surgery; University of Insubria; Antonietta D'Errico (St. Orsola-Malpighi Hospital; University of Bologna; Bologna); Deborah Malvi (St. Orsola-Malpighi Hospital; Claudia Mescoli (Department of Medicine; University of Padua; Padua); Massimo Rugge (Department of Medicine; Stefano Ferrero (Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Gilberto Poggioli (St. Orsola-Malpighi Hospital; Fernando Rizzello (St. Orsola-Malpighi Hospital; Maria C Macciomei (San Camillo-Forlanini Hospital; Rome); Donatella Santini (St. Orsola-Malpighi Hospital; Umberto Volta (Department of Medical and Surgical Sciences; Roberto De Giorgio (Department of Morphology; Surgery and Experimental Medicine; University of Ferrara; Ferrara); Giacomo Caio (Department of Morphology; Antonio Calabrò (Department of Experimental and Clinical Biomedical Sciences; Carolina Ciacci (Department of Medicine and Surgery; University of Salerno; Salerno); Maria D'Armiento (Public Health Department; Federico II University of Naples; Naples); Aroldo Rizzo (Cervello Hospital; Palermo); Gaspare Solina (Cervello Hospital; Francesco Tonelli (Surgery and Translational Medicine; Vincenzo Villanacci (Spedali Civili Hospital; Brescia); Renato Cannizzaro (Centro di Riferimento Oncologico (CRO) di Aviano IRCCS; Aviano); Vincenzo Canzonieri (Centro di Riferimento Oncologico (CRO) di Aviano IRCCS; Ada M Florena (Department of Health Promotion; Mother and Child Care; Internal Medicine and Medical Specialties; University of Palermo; Livia Biancone (Department of Systems Medicine; University of Tor Vergata; Giovanni Monteleone (Department of Systems Medicine; Roberto Caronna (Department of Surgical Sciences; La Sapienza University; Antonio Ciardi (Umberto I Hospital; Luca Elli (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Flavio Caprioli (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Maurizio Vecchi (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Renata D'Incà (Department of Surgery; Oncology and Gastroenterology; Fabiana Zingone (Department of Surgery; Anna D'Odorico (Department of Surgery; Barbara Oreggia (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Luca Reggiani Bonetti (Department of Diagnostic Medicine and Public Health; University of Modena and Reggio Emilia; Modena); Marco Astegiano (Città della Salute e della Scienza-Molinette Hospital; Turin); Laura Cantoro (USL Umbria 1; Perugia); Claudio Papi (San Filippo Neri Hospital; Giancarlo Sandri (Sant'Eugenio Hospital; Marco Silano (Istituto Superiore di Sanità; Paolo Usai (Department of Internal Medicine; University of Cagliari; Cagliari); Vittorio Perfetti (S. S. Annunziata Hospital; ASST-Pavia Varzi); Erica Quaquarini (ICS Maugeri-IRCCS SpA SB; Antonino G Giannone (Department of Health Promotion; Augusto Orlandi (Department of Biopathology and Image Diagnostics; Valeria Barresi (University and Hospital Trust of Verona; Verona); Rachele Ciccocioppo (AOUI Policlinico G. B. Rossi and University of Verona; Giuseppe Amodeo (AOUI Policlinico G. B. Rossi and University of Verona; Elena Biletta (ASL Biella; Biella); Andrea Casadei-Gardini (IRCCS San Raffaele Scientific Institute Hospital; Ombretta Luinetti (IRCCS San Matteo Hospital Foundation; Gino Roberto Corazza (IRCCS San Matteo Hospital Foundation; Matteo Fassan; Belgium: Annick Moens (University Hospitals; KU Leuven; Leven); Gert De Hertog (University Hospitals; and Marc Ferrante (University Hospitals; United States: Rondell P Graham (Mayo Clinic, Rochester). |
| Contributors: | Giovanni, Arpa; Alessandro, Vanoli; Francesca, Antoci; Marco Vincenzo, Lenti; Antonio, Di Sabatino; Bowel Carcinoma Consortium Collaborators for their support: Italy: Camilla Guerini (IRCCS San Matteo Hospital Foundation, Small; Pavia); Grillo (Ospedale Policlinico San Martino University Hospital, Federica; Genoa); Ilaria Bianchi (IRCCS San Matteo Hospital Foundation, Paola; Aronico (IRCCS San Matteo Hospital Foundation, Nicola; Libera (Department of Medicine and Surgery and Research Center for the Study of Hereditary and Familial Tumors, Laura; Varese); Furlan (Department of Medicine and Surgery and Research Center for the Study of Hereditary and Familial Tumors, Daniela; Travaglino (IRCCS San Matteo Hospital Foundation, Erica; Nesi (Department of Surgery and Translational Medicine, Gabriella; Of Florence, University; Florence); Sampietro (ASST Rhodense, Gianluca; Hospital, Rho; Milan); Ardizzone (Luigi Sacco University Hospital, Sandro; Fociani (ASST Ovest Milanese, Paolo; Fiocca (Ospedale Policlinico San Martino University Hospital, Roberto; Latella (Department of Life and Environmental Sciences, Giovanni; Of L'Aquila, University; L'Aquila); Sessa (Department of Medicine and Surgery, Fausto; Of Insubria, University; Orsola-Malpighi Hospital, Antonietta D'Errico (St.; Of Bologna, University; Bologna); Orsola-Malpighi Hospital, Deborah Malvi (St.; Mescoli (Department of Medicine, Claudia; Of Padua, University; Padua); Rugge (Department of Medicine, Massimo; Ferrero (Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Stefano; Orsola-Malpighi Hospital, Gilberto Poggioli (St.; Orsola-Malpighi Hospital, Fernando Rizzello (St.; C Macciomei (San Camillo-Forlanini Hospital, Maria; Rome); Orsola-Malpighi Hospital, Donatella Santini (St.; Volta (Department of Medical and Surgical Sciences, Umberto; De Giorgio (Department of Morphology, Roberto; And Experimental Medicine, Surgery; Of Ferrara, University; Ferrara); Caio (Department of Morphology, Giacomo; Calabrò (Department of Experimental and Clinical Biomedical Sciences, Antonio; Ciacci (Department of Medicine and Surgery, Carolina; Of Salerno, University; Salerno); D'Armiento (Public Health Department, Maria; Ii University Of Naples, Federico; Naples); Rizzo (Cervello Hospital, Aroldo; Palermo); Solina (Cervello Hospital, Gaspare; Tonelli (Surgery and Translational Medicine, Francesco; Villanacci (Spedali Civili Hospital, Vincenzo; Brescia); Cannizzaro (Centro di Riferimento Oncologico (CRO) di Aviano IRCCS, Renato; Aviano); Canzonieri (Centro di Riferimento Oncologico (CRO) di Aviano IRCCS, Vincenzo; M Florena (Department of Health Promotion, Ada; And Child Care, Mother; Medicine And Medical Specialties, Internal; Of Palermo, University |
| Publication Year: | 2024 |
| Collection: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Description: | Introduction: Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. Methods: This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis). Results: The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group ( P = 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA. Discussion: EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37966091; info:eu-repo/semantics/altIdentifier/wos/WOS:001236991100003; journal:THE AMERICAN JOURNAL OF GASTROENTEROLOGY; https://hdl.handle.net/11577/3504591 |
| DOI: | 10.14309/ajg.0000000000002585 |
| Availability: | https://hdl.handle.net/11577/3504591; https://doi.org/10.14309/ajg.0000000000002585 |
| Rights: | info:eu-repo/semantics/closedAccess ; license:Accesso privato - non pubblico ; license uri:iris.PRI01 |
| Accession Number: | edsbas.7CB2F66F |
| Database: | BASE |