| Title: |
Body mass index across adulthood and the development of airflow obstruction and emphysema |
| Authors: |
Trethewey, Ruth E; Spartano, Nicole L; Vasan, Ramachandran S; Larson, Martin G; O’Connor, George T; Esliger, Dale W; Petherick, Emily S; Steiner, Michael C |
| Contributors: |
National Centre for Exercise Medicine and the School of Sport, Exercise and Health Sciences at Loughborough University; NIHR Leicester Biomedical Research Centre; National Heart, Lung, and Blood Institute (NHLBI) in collaboration with Boston University |
| Source: |
Chronic Respiratory Disease ; volume 19 ; ISSN 1479-9731 1479-9731 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2022 |
| Description: |
Background Low body mass index (BMI) is associated with COPD, but temporal relationships between airflow obstruction (AO) development and emphysematous change are unclear. We investigated longitudinal changes in BMI, AO, and lung density throughout adulthood using data from the Framingham Offspring Cohort (FOC). Methods BMI trajectories were modelled throughout adulthood in 4587 FOC participants from Exam 2 (mean age = 44), through Exam 9 (mean age = 71), in AO participants and non-AO participants (AO n = 1036), determined by spirometry, using fractional polynomial growth curves. This process was repeated for low lung density (LLD) and non LLD participants (LLD n = 225) determined by Computed Tomography. Spirometry decline was compared separately between tertiles of BMI in those aged |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/14799731221139294 |
| Availability: |
https://doi.org/10.1177/14799731221139294; https://journals.sagepub.com/doi/pdf/10.1177/14799731221139294; https://journals.sagepub.com/doi/full-xml/10.1177/14799731221139294 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.7CE48F31 |
| Database: |
BASE |