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Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial

Title:	Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial
Authors:	Reynolds, Harmony R.; Cyr, Derek D.; Merz, C. Noel Bairey; Shaw, Leslee J.; Chaitman, Bernard R.; Boden, William E.; Alexander, Karen P.; Rosenberg, Yves D.; Bangalore, Sripal; Stone, Gregg W.; Held, Claes; Spertus, John; Goetschalckx, Kaatje; Bockeria, Olga; Newman, Jonathan D.; Berger, Jeffrey S.; Elghamaz, Ahmed; Lopes, Renato D.; Min, James K.; Berman, Daniel S.; Picard, Michael H.; Kwong, Raymond Y.; Harrington, Robert A.; Thomas, Boban; O'Brien, Sean M.; Maron, David J.; Hochman, Judith S.; Mavromatis, Kreton; Linefsky, Jason; Miller, Todd; Banerjee, Subhash; Donnino, Robert M.; Phillips, Lawrence M.; Saric, Muhamed; Abdul‐Nour, Khaled; Stone, Peter H.; Jang, James J.; Yee, Gennie; Weitz, Steven; Arnold, Suzanne; O’Keefe, James Henry; Shapiro, Michael D.; El‐Hajjar, Mohammad; Sidhu, Mandeep S.; Fein, Steven A.; Torosoff, Mikhail T.; Lyubarova, Radmila; Mookherjee, Sulagna; Drzymalski, Krzysztof; McFalls, Edward O.; Garcia, Santiago A.; Bertog, Stefan C.; Siddiqui, Rizwan A.; Ishani, Areef; Hansen, Ronnell A.; Khouri, Michel Georges; Goldberg, Jonathan L.; Goldweit, Richard; Cohen, Ronny A.; Mirrer, Brooks; Navarro, Victor; Winchester, David E.; Kronenberg, Marvin; Rogal, Philip; McFarren, Christopher; Heitner, John F.; Dauber, Ira M.; Cannan, Charles; Sudarshan, Sriram; Mehta, Puja K.; McDaniel, Michael; Lerakis, Stamatios; Quyyumi, Arshed; Wenger, Nanette K.; Hedgepeth, Chester M.; Hurlburt, Heather; Rosen, Alan; Sahul, Zakir; Booth, David; Leung, Steve; Abdel‐Latif, Ahmed; Reda, Hassan; Ziada, Khaled; Setty, Sampoornima; Barua, Rajat S.; Hage, Fadi; Caldeira, Christiano; Davies, James E.; Leesar, Massoud; Heo, Jaekyeong; Iskandrian, Amy; Al Solaiman, Firas; Singh, Satinder; Dajani, Khaled; Der Mesropian, Paul; Sacco, Joseph; McCandless, Brian; Orgera, Marisa; Arif, Imran; Kerr, Hanan; Trejo (Gutierrez), Jorge F.; Fletcher, Gerald; Lane, Gary E.; Neeson, Lynn M.; Parikh, Pragnesh P.; Pollak, Peter M.; Shapiro, Brian P.; Landolfo, Kevin; Gemignani, Anthony; O’Rourke, Daniel; Meadows, Judith L.; Call, Jason T.; Hannan, Joseph; Bojar, Robert; Kumar, Deepti; Mukai, John; Martin, Edward T.; Vorobiof, Gabriel; Moorman, Alec; Kinlay, Scott; Hamburger, Robert J.; Rocco, Thomas P.; Bhatt, Deepak L.; Croce, Kevin; Quin, Jacquelyn A.; Anumpa, Jati; Zenati, Marco; Faxon, David P.; Rayos, Glenn; Seedhom, Ashraf; Sullenberger, Lance; Kumkumian, Gregory; Sedlis, Steven P.; Lorin, Jeffrey; Tamis‐Holland, Jacqueline E.; Kornberg, Robert; Leber, Robert; Saba, Souheil; Lee, Michael W.; Small, Delano R.; Nona, Wassim; Alexander, Patrick B.; Rehman, Iram; Badami, Umesh; Marzo, Kevin; Robbins, Inga H.; Levite, Howard A.; Shetty, Sanjay; Patel, Mayuri; Hamroff, Glenn S.; Little, Raymond W.; Zimbelman, Brandi D.; Lui, Charles Y.; Smith, Brigham R.; Vezina, Daniel P.; Khor, Lillian L.; Abraham, Josephine D.; Bull, David A.; McKellar, Stephen H.; Kotter, John; Hu, Bob; Labovitz, Arthur J.; Berlowitz, Michael; Matar, Fadi; Rodriguez, Fatima; Schnittger, Ingela; Fearon, William F.; Deedwania, Prakash; Reddy, Kiran; Sweeny, Joseph; Spizzieri, Christopher; Hochberg, Claudia P.; Salerno, William D.; Wyman, Ray; Zarka, Amer; Shah, Anil V.; Haldis, Thomas; Kohn, Jeffrey A.; Girotra, Saket; Almousalli, Omar; Krishnam, Mayil S.; Milliken, Jeffrey C.; Patel, Pranav M.; Seto, Arnold H.; Harley, Kevin T.; Gibson, Michael A.; Allen, Byron J.; Coram, Rita; Thomas, Sabu; Schwartz, Ronald G.; Chen, Wei; El Shahawy, Mahfouz; Stafford, James; Abernethy, William B.; Zurick, Andrew; Meyer, Thomas M.; Morford, Ronald G.; Rutkin, Bruce; Bokhari, Sabahat; Sokol, Seth I.; Meisner, Jay; Hamzeh, Ihab; Misra, Arunima; Wall, Matthew; De Rosen, Veronica Lenges; Alam, Mahboob; Turner, Michael C.; Mulhearn, Thomas J.; Good, Arnold P.; Shammas, Nicolas W.; Chilton, Robert; Nguyen, Patricia K.; Jezior, Matthew; Gordon, Paul C.; Crain, Thomas; Stenberg, Robert; Pedalino, Ronald P.; Wiesel, Joseph; Juang, George J.; Al‐Amoodi, Mohammed; Wohns, David; Lader, Ellis W.; Mumma, Michael; Dharmarajan, Lekshmi; McGarvey, Joseph F. X.; Downes, Thomas R.; Luckasen, Gary J.; Cheong, Benjamin; Potluri, Srinivasa; Mastouri, Ronald A.; Breall, Jeffery A.; Revtyak, George E.; Bazeley, Jonathan W.; Li, Dayuan; Giedd, Kenneth; Old, Wayne; Burt, Francis; Sokhon, Kozhaya; Gopal, Deepika; Valeti, Uma S.; Kobashigawa, Jon; Govindan, Sajeev Chakanalil; Nair, Rajesh Gopalan; Manjunath, Cholenahally Nanjappa; Moorthy, Nagaraja; Manjunath, Satvic Cholenahally; Narayanappa, Suryaprakash; Pandit, Neeraj; Nath, Ranjit Kumar; Dwivedi, S. K.; Narain, V. S.; Chandra, Sharad; Wander, Gurpreet S.; Tandon, Rohit; Ralhan, Sarju; Aslam, Naved; Goyal, Abhishek; Bhargava, Balram; Karthikeyan, G.; Ramakrishnan, S.; Seth, Sandeep; Yadav, Rakesh; Singh, Sandeep; Roy, Ambuj; Parakh, Neeraj; Verma, Sunil Kumar; Narang, Rajiv; Mishra, Sundeep; Naik, Nitish; Sharma, Gautam; Choudhary, Shiv Kumar; Patel, Chetan; Gulati, Gurpreet; Sharma, Sanjeev; Bahl, V. K.; Mathew, Anoop; Punnoose, Eapen; Gadkari, Milind Avdhoot; Gadage, Siddharth; Pillay, Tapan Umesh; Satheesh, Santhosh; Mathur, Atul; Kaul, Upendra; Christopher, Johann; Menon, Rajeev; Kumar, Nirmal; Oomman, Abraham; Mao, Robert; Solomon, Hilda; Naik, Sudhir; Khan, Sajeeda Parveen; Grant, Purvez; Kachru, Ranjan; Ajit Kumar, V. K.; Ganapathi, Sanjay; Jayakumar, K.; Sivadasanpillai, Harikrishnan; Sasidharan, Bijulal; Kapilamoorthy, T. R.; Polamuri, Praneeth; Senior, Roxy; Gurunathan, Sothinathan; Karogiannis, Nikolaos; Shah, Benoy N.; Trimlett, Richard HJ; Rubens, Michael B.; Nicol, Edward D.; Mittal, Tarun K.; Hampson, Reinette; Gamma, Reto Andreas; de Belder, Mark A.; Thambyrajah, Jeet; Nageh, Thuraia; Davies, John R.; Lindsay, Steven J.; Kurian, John; Jamil, Haqeel; Raheem, Osama; Hoye, Angela; Donnelly, Patrick; Valecka, Bernardas; Chauhan, Anoop; Barr, Craig; Alfakih, Khaled; Byrne, Jonathan; Webb, Ian; Henriksen, Peter; OKane, Peter; de Silva, Ramesh; Conway, Dwayne S. G.; Sirker, Alexander A; Hoole, Stephen P.; Witherow, Fraser N.; Johnston, Nicola; Harbinson, Mark; Walsh, Simon; Douglas, Hanna; Luckie, Matthew; Sobolewska, Jolanta; Jeetley, Paramjit; Patel, Niket; Kotecha, Tushar; Travill, Christopher; Karimullah, Iqbal; Al‐Bustami, Mahmud; Braganza, Denise; Henderson, Robert; Pointon, Kate; Naik, Surendra; Mathew, Thomas; Berry, Colin; Collison, Damien; Roditi, Giles; Moriarty, Andrew J.; Glover, Jason D.; Pradhan, Jiwan; Mikhail, Ghada; Francis, Darrel P.; Gosselin, Gilbert; Diaz, Ariel; Rheault, Philippe; Barrero, Miguel; Gagné, Carl‐Éric; Pépin‐Dubois, Yanek; Costa, Ricardo; Sia, Ying Tung; Lemay, Catherine; Gisbert, Alejandro; Gervais, Pierre; Rheault, Alain; Phaneuf, Denis Carl; Garg, Pallav; Chow, Benjamin J. W.; Hessian, Renee C.; Beanlands, Rob S.; Davies, Richard F.; Bainey, Kevin R.; Cheema, Asim N.; Bagai, Akshay; Wald, Ron; Goodman, Shaun; Graham, John Joseph; Peterson, Mark; Chow, Chi‐Ming; Abramson, Beth; Cheema, Asim Nazir; Vakani, Mohammad Tariq; Cha, James; Howarth, Andrew G; Wong, Graham; Uxa, Amar; Galiwango, Paul; Kassam, Saleem; Mukherjee, Ashok; Ricci, A. Joseph; Lam, Andy; Mehta, Shamir; Udell, Jacob; Généreux, Philippe; Hameed, Adnan; Daba, Ledjalem; Hueb, Whady; Rezende, Paulo Cury; Silva, Expedito Eustáquio Ribeiro; Hueb, Alexandre Ciappina; Smanio, Paola Emanuela Poggio; de Quadros, Alexandre Schaan; Kalil, Renato Abdala Karam; da Costa Vieira, José Luiz; Grossmann, Gabriel; de Oliveira, Pedro Píccaro; Bridi, Leonardo; Savaris, Simone; Vitola, João V.; Cerci, Rodrigo J.; Farias, Fabio R.; Fernandes, Miguel M.; Marin‐Neto, José Antonio; Schmidt, André; de Oliveira Lima Filho, Moysés; Oliveira, Ricardo Mendes; Chierice, João Reynaldo Abbud; Polanczyk, Carísi A.; Furtado, Mariana V.; Smidt, Luis F.; Carvalho, Antonio Carlos; Pucci, Gustavo; Lyra, Flavio; Junior, Alvaro Rabelo Alves; Dracoulakis, Marianna D. A.; Lima, Rodolfo G. S. D; Figueiredo, Estevao; Caramori, Paulo Ricardo; Tumelero, Rogerio; Dall’Orto, Frederico; Mesquita, Claudio T.; Colafranseschi, Alexandre S.; Oliveira, Amarino C.; Carvalho, Luiz A.; Palazzo, Isabella C.; Sousa, Andre S.; da Silva, Expedito Eustáquio Ribeiro; de Barros, Pedro Gabriel Melo; de Pádua Silva Baptista, Luciana; Rodrigues, Marcelo Jamus; de Resende, Marcos Valério Coimbra; Saraiva, Jose Francisco; Costantini, Costantino; Demkow, Marcin; Pracon, Radoslaw; Kepka, Cezary; Teresinska, Anna; Kryczka, Karolina; Henzel, Jan; Solecki, Mateusz; Kaczmarska, Edyta; Mazurek, Tomasz; Drozdz, Jaroslaw; Czarniak, Bartosz; Frach, Malgorzata; Szymczyk, Konrad; Niedzwiecka, Iwona; Sobczak, Sebastian; Ciurus, Tomasz; Jakubowski, Piotr; Misztal‐Teodorczyk, Magdalena; Teodorczyk, Dawid; Fratczak, Aleksandra; Szkopiak, Marcin; Lebioda, Patrycja; Wlodarczyk, Michal; Plachcinska, Anna; Kusmierek, Jacek; Miller, Magdalena; Marciniak, Halina; Wojtczak‐Soska, Karolina; Luczak, Katarzyna; Tarchalski, Tomasz; Cichocka‐Radwan, Anna; Szwed, Hanna; Szulczyk, Grazyna Anna; Witkowski, Adam; Kukula, Krzysztof; Celinska‐Spodar, Malgorzta; Zalewska, Joanna; Gajos, Grzegorz; Bury, Krzysztof; Pruszczyk, Piotr; Roik, Marek; Loboz‐Grudzien, Krystyna; Sokalski, Leszek; Brzezinska, Barbara; Lesiak, Maciej; Lanocha, Magdalena; Reczuch, Krzysztof W.; Kalarus, Zbigniew; Swiatkowski, Andrzej; Szulik, Mariola; Musial, Wlodzimierz J.; Bockeria, Leo; Petrosyan, Karen; Trifonova, Tatiana; Chernyavskiy, Alexander M.; Kretov, Evgeniy I.; Grazhdankin, Igor O.; Bershtein, Leonid L.; Sayganov, Sergey A.; Kuzmina‐Krutetskaya, Anastasia M.; Zbyshevskaya, Elizaveta V.; Katamadze, Nana O.; Demchenko, Elena A.; Kozlov, Pavel S.; Kozulin, Vikentiy Y.; Lubinskaya, Ekaterina I.; Lopez‐Sendon, Jose; Castro, Almudena; Salicio, Elena Refoyo; Guzman, Gabriela; Galeote, Gabriel; Valbuena, Silvia; Peteiro, Jesús; Martínez‐Ruíz, María Dolores; Pérez‐Fernández, Ruth; Cuenca‐Castillo, José J.; Flores‐Ríos, Xacobe; Prada‐Delgado, Óscar; Barge‐Caballero, Gonzalo; Juanatey, Jose Ramon Gonzalez; Bayarri, Miguel Souto; Nuñez, Virginia Pubull; Sanchez, Raymundo Ocaranza; Alvarez, Belen Cid; Gil, Carlos Peña; Monzonis, Amparo Martinez; Sionis, Alessandro; Perales, Montserrat Vila; Padró, Josep Maria; Peñaranda, Antonio Serra; Picart, Joan García; Iglesias, Antonino Ginel; Marimon, Xavier Garcia‐Moll; Lladó, Guillem Pons; Costa, Francesc Carreras; Miro, Vicente; Diez, Jose L.; Calvillo, Pilar; Ortuño, F. Marin; Chávarri, M. Valdés; Montolliu, A. Tello; Bermudez, E. Pinar; De La Morena, G.; Blancas, Montserrat Gracida; Luena, Jose Enrique Castillo; Fernandez‐Aviles, Francisco; Chen, Jiyan; Wu, Yongjian; Ma, Yitong; Yang, Yining; Ji, Zheng; Yang, Xinchun; Lin, Wenhua; Zeng, Hesong; Fu, Xin; Yang, Bin; Wang, Songtao; Cheng, Gong; Zhao, Yulan; Fang, Xuehua; Zeng, Qiutang; Su, Xi; Li, Qingxian; Nie, Shao‐ping; Yu, Qin; Wang, Jian’an; Zhang, Shuyang; Liu, Zhenyu; Perna, Gian Piero; Marini, Marco; Gabrielli, Gabriele; Provasoli, Stefano; Verna, Edoardo; Monti, Lorenzo; Nardi, Barbara; Di Chiara, Antonio; Mortara, Andrea; Galvani, Marcello; Ottani, Filippo; Sicuro, Marco; Calabro, Paolo; Formisano, Tiziana; Tarantini, Giuseppe; Cucchini, Umberto; Andres, Anto Luigi; Racca, Emanuela; Briguori, Carlo; Amati, Roberto; Vergoni, William; Russo, Aldo; Fanelli, Raffaele; Poh, Kian‐Keong; Chai, Ping; Lau, Titus; Loh, Joshua P.; Tay, Edgar L.; Teoh, Kristine; Teo, Lynette L.; Ong, Ching‐Ching; Wong, Raymond C.; Loh, Poay‐Huan; Kofidis, Theodoros; Chan, Wan Xian; Chan, Koo Hui; Foo, David; Kong, Jason Loh Kwok; Er, Ching Min; Jafary, Fahim Haider; Chua, Terrance; Doerr, Rolf; Stumpf, Juergen; Matschke, Klaus; Simonis, Gregor; Kadalie, Clemens T.; Sechtem, Udo; Ong, Peter; Schulze, P. Christian; Goebel, Bjoern; Lenk, Karsten; Nickenig, Georg; Schuchlenz, Herwig; Weikl, Stefan; Lang, Irene Marthe; Huber, Kurt; Jakl‐Kotauschek, Gabriele; Vertes, Andras; Varga, Albert; Fontos, Geza; Merkely, Bela; Kerecsen, Gabor; Hinic, Sasa; Zdravkovic, Marija; Mudrenovic, Vladan; Crnokrak, Bogdan; Beleslin, Branko D.; Boskovic, Nikola N.; Petrovic, Marija T.; Dobric, Milan R.; Markovic, Zeljko Z.; Mladenovic, Ana S.; Cemerlic‐Adjic, Nada; Davidovic, Goran; Vucic, Rada; Dekleva, Milica Nikola; Stankovic, Goran; Apostolovic, Svetlana; Escobedo, Jorge; Baleón‐Espinosa, Rubén; Campos‐Santaolalla, Arturo S.; Durán‐Cortés, Elihú; Flores‐Palacios, José M.; García‐Rincón, Andrés; Jiménez‐Santos, Moisés; Peñafiel, Joaquín V.; Ortega‐Ramírez, José A.; Valdespino‐Estrada, Aquiles; Rosas, Erick Alexánderson; Selvanayagam, Joseph B.; Joseph, Majo X.; Thambar, Suku T.; Beltrame, John F.; Hillis, Graham S.; Thuaire, Christophe; Dutoiu, Téodora; Steg, Philippe Gabriel; Juliard, Jean‐Michel; Slama, Michel S.; El Mahmoud, Rami; Nicollet, Eric; Goube, Pascal; Barone‐Rochette, Gilles; Furber, Alain; Bière, Loïc; Laucevicius, Aleksandras; Celutkiene, Jelena; Kedhi, Elvin; Timmer, Jorik; Hermanides, Rik; Kaplan, Eliza; Riezebos, Robert K.; Samadi, Pouneh; van Dongen, Elise; Niehe, Sander R.; Suryapranata, Harry; van Vugt, Stijn; Ramos, Ruben; Cacela, Duarte; Santana, Ana; Fiarresga, Antonio; Sousa, Lidia; Marques, Hugo; Patricio, Lino; Bernanrdes, Luis; Rio, Pedro; Carvalho, Ramiro; Ferreira, Rui; Silva, Tiago; Rodrigues, Ines; Modas, Pedro; Portugal, Guilherme; Fragata, Jose; Pinto, Fausto J.; Menezes, Miguel Nobre; Lopes, Guilhermina Cantinho; Almeida, Ana Gomes; Silva, Pedro Canas; Nobre, Angelo; Francisco, Ana Rita; Ferreira, Nuno; Lopes, Ricardo L.; Guzman, Luis; Figal, Julio César; Méndiz, Oscar; Cortés, Claudia; Favaloro, Roberto René; Alvarez, Carlos; Courtis, Javier; Zeballos, Gabriela; Schiavi, Lilia; Rubio, Mariano; Devlin, Gerard Patrick; Fisher, Raewyn; Stewart, Ralph Alan Huston; White, Harvey Douglas; Benatar, Jocelyne; Kedev, Sasko; Mitevska, Irena Peovska; Kostovska, Elizabeta Srbinovska; Pejkov, Hristo; Eggers, Kai; Frostfelt, Gunnar; Johnston, Nina; Olsowka, Maciej; Åkerblom, Axel; Soveri, Inga; Aspberg, Johannes; Sharir, Tali; Elian, Dan; Kerner, Arthur; Massalha, Samia; Fukuda, Keiichi; Kohsaka, Shun; Yasuda, Satoshi; Nishimura, Shigeyuki; Van de Werf, Frans; Claes, Kathleen; Hung, Chung‐Lieh; Yun, Chun‐Ho; Hou, Charles Jia‐Yin; Kuo, Jen‐Yuan; Yeh, Hung‐I; Hung, Ta‐Chuan; Li, Jiun‐Yi; Chien, Chen‐Yen; Tsai, Cheng‐Ting; Liu, Chun‐Chieh; Yu, Fa‐Chang; Lin, Yueh‐Hung; Lan, Wei‐Ren; Yen, Chih‐Hsuan; Tsai, Jui‐Peng; Sung, Kuo‐Tzu; Ntsekhe, Mpiko; Pandie, Shaheen; Viljoen, Charle A.; De Andrade, Marianne; Moccetti, Tiziano; Rossi, M. Grazia; Abdelhamid, Magdy; Adel, Ahmed; Kamal, Ahmed; Mahrous, Hossam; El Kaffas, Sameh; El Fishawy, Hussien; Pop, Calin; Claudia, Matei; Popescu, Bogdan A.; Ginghina, Carmen; Deleanu, Dan; Iliescu, Vlad A.; Al‐Mallah, Mouaz H.; Aljzeeri, Ahmed; Najm, Hani; Alghamdi, Ali; Ramos, Walter Enrique Mogrovejo; Kuanprasert, Srun; Prommintikul, Arintaya; Nawarawong, Weerachai; Woragidpoonpol, Surin; Tepsuwan, Thitipong; Taksaudom, Noppon; Rimsukcharoenchai, Chataroon; Euathrongchit, Juntima; Wannasopha, Yutthaphan; Yamwong, Sukit; Sritara, Piyamitr; Aramcharoen, Suthara; Meemuk, Krissada; Khairuddin, Ahmad; Hadi, Hafidz Abd; Yahaya, Shaiful Azmi
Contributors:	Reynolds, Harmony R.; Cyr, Derek D.; Merz, C. Noel Bairey; Shaw, Leslee J.; Chaitman, Bernard R.; Boden, William E.; Alexander, Karen P.; Rosenberg, Yves D.; Bangalore, Sripal; Stone, Gregg W.; Held, Clae; Spertus, John; Goetschalckx, Kaatje; Bockeria, Olga; Newman, Jonathan D.; Berger, Jeffrey S.; Elghamaz, Ahmed; Lopes, Renato D.; Min, James K.; Berman, Daniel S.; Picard, Michael H.; Kwong, Raymond Y.; Harrington, Robert A.; Thomas, Boban; O'Brien, Sean M.; Maron, David J.; Hochman, Judith S.; Mavromatis, Kreton; Linefsky, Jason; Miller, Todd; Banerjee, Subhash; Donnino, Robert m.; Phillips, Lawrence M.; Saric, Muhamed; Abdul‐nour, Khaled; Stone, Peter H.; Jang, James J.; Yee, Gennie; Weitz, Steven; Arnold, Suzanne; O’Keefe, James Henry; Shapiro, Michael D.; El‐hajjar, Mohammad; Sidhu, Mandeep S.; Fein, Steven A.; Torosoff, Mikhail T.; Lyubarova, Radmila; Mookherjee, Sulagna; Drzymalski, Krzysztof; Mcfalls, Edward O.; Garcia, Santiago A.; Bertog, Stefan C.; Siddiqui, Rizwan A.; Ishani, Areef; Hansen, Ronnell A.; Khouri, Michel George; Goldberg, Jonathan L.; Goldweit, Richard; Cohen, Ronny A.; Mirrer, Brook; Navarro, Victor; Winchester, David E.; Kronenberg, Marvin; Rogal, Philip; Mcfarren, Christopher; Heitner, John F.; Dauber, Ira M.; Cannan, Charle; Sudarshan, Sriram; Mehta, Puja K.; Mcdaniel, Michael; Lerakis, Stamatio; Quyyumi, Arshed; Wenger, Nanette K.; Hedgepeth, Chester M.; Hurlburt, Heather; Rosen, Alan; Sahul, Zakir; Booth, David; Leung, Steve; Abdel‐latif, Ahmed; Reda, Hassan; Ziada, Khaled; Setty, Sampoornima; Barua, Rajat S.; Hage, Fadi; Caldeira, Christiano; Davies, James E.; Leesar, Massoud; Heo, Jaekyeong; Iskandrian, Amy; Al Solaiman, Fira; Singh, Satinder; Dajani, Khaled; Der Mesropian, Paul; Sacco, Joseph
Publication Year:	2024
Collection:	Padua Research Archive (IRIS - Università degli Studi di Padova)
Subject Terms:	coronary artery disease; ischemic heart disease; sex difference; women's health
Description:	Background: Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline-directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on stress testing, with and without invasive management. Methods and results: The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial randomized patients with moderate or severe ischemia to invasive management with angiography, revascularization, and guideline-directed medical therapy, or initial conservative management with guideline-directed medical therapy alone. We evaluated the primary outcome (cardiovascular death, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest) and other end points, by sex, in 1168 (22.6%) women and 4011 (77.4%) men. Invasive group catheterization rates were similar, with less revascularization among women (73.4% of invasive-assigned women revascularized versus 81.2% of invasive-assigned men; P
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/38410945; info:eu-repo/semantics/altIdentifier/wos/WOS:001215553400002; volume:13; issue:5; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; https://hdl.handle.net/11577/3510849
DOI:	10.1161/jaha.122.029850
Availability:	https://hdl.handle.net/11577/3510849; https://doi.org/10.1161/jaha.122.029850
Rights:	info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/
Accession Number:	edsbas.7D1D2DA4
Database:	BASE