| Title: |
BDNF VAL66MET polymorphism impacts alertness and performance in shift workers |
| Authors: |
Burns, AC; Sletten, TL; Magee, M; Hawi, Z; Nicholas, CL; Saxena, R; Ftouni, S; Grunstein, R; Kennaway, D; Ferguson, S; Lockley, SW; Rajaratnam, SW; Cain, SW |
| Source: |
Burns, AC, Sletten, TL, Magee, M, Hawi, Z, Nicholas, CL, Saxena, R, Ftouni, S, Grunstein, R, Kennaway, D, Ferguson, S, Lockley, SW, Rajaratnam, SW, Cain, SW, (2017). BDNF VAL66MET polymorphism impacts alertness and performance in shift workers. SLEEP, Vol. 40, No. suppl_1, p. A11-A11 http://dx.doi.org/10.1093/sleepj/zsx050.028 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2017 |
| Collection: |
Central Queensland University: aCQUIRe |
| Subject Terms: |
alleles; polymorphism; consciousnesses related finding; electroencephalography; homeostasis; brain-derived neurotrophic factor; genotype; homozygote; reaction time; spectrum analysis; genetics; genetic aspects; sleep; drowsiness; medical research; shift work; genotype determination; sleep restriction therapy; emotional vulnerability; val66met polymorphism; 111705 Environmental and Occupational Health and Safety; 170101 Biological Psychology (Neuropsychology; Psychopharmacology; Physiological Psychology) |
| Description: |
Ferguson, SA orcid:0000-0002-9682-7971 ; Introduction: Night shift work typically occurs under conditions of circadian misalignment and sleep restriction, resulting in impaired performance and alertness. There is inter-individual variability in the degree of impairment consequent to shift work, though little is known about the genetic factors that confer resistance or vulnerability. Brain Derived Neurotrophic Factor (BDNF) is a potent modulator of sleep-wake homeostasis and contains a common functional polymorphism in its pro-domain (val66met). The present study examined whether the val66met polymorphism explained inter-individual variability in shift work tolerance as measured by the psychomotor vigilance task (PVT) and electroencephalographic (EEG) correlates of alertness. Methods: Forty-eight night shift workers completed an in-laboratory, simulated night shift and were genotyped for the val66met polymorphism (TaqMan assay; rs6265). Participants completed the auditory PVT and the Karolinska Drowsiness Test (KDT) during the shift. Results: Genotyping of val66met identified 27 val/val homozygotes (19 males; age 32.5±9.5) and 21 met allele carriers (12 males; age 31.3±9.0). Both mean reaction time and attentional lapses increased as a function of time into the simulated night shift, reflecting a general worsening of performance (both p |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
0161-8105; 1550-9109 |
| Relation: |
SLEEP, 2017, Vol. 40, No. suppl_1, p. A11-A11; http://hdl.cqu.edu.au/10018/1235924; cqu:15470; http://dx.doi.org/10.1093/sleepj/zsx050.028; eISSN:1550-9109 |
| DOI: |
10.1093/sleepj/zsx050.028 |
| Availability: |
http://hdl.cqu.edu.au/10018/1235924; https://doi.org/10.1093/sleepj/zsx050.028 |
| Rights: |
open access |
| Accession Number: |
edsbas.7D888C14 |
| Database: |
BASE |